Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages

Microglial depletion aggravates the severity of acute and chronic seizures in mice

(2020) Wenning Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus

(2020) Nicholas H. Varvel et al.   JOURNAL OF NEUROSCIENCE

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

(2019) Lijie Feng et al.   GLIA

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

(2019) Renzo Mancuso et al.   BRAIN

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

(2019) Matthew L. Neal et al.   FASEB JOURNAL

Emerging Roles for Microglial Phagocytic Signaling in Epilepsy

(2019) Season K. Wyatt-Johnson et al.   Epilepsy Currents

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

(2018) Dale B. Bosco et al.   Molecular Brain

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

Microglia after Seizures and in Epilepsy

(2018) Toshimitsu Hiragi et al.   Cells

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

(2018) Prashant K. Srivastava et al.   Nature Communications

Microglial phenotypes in the human epileptic temporal lobe

(2018) Mélanie Morin-Brureau et al.   BRAIN

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury

(2018) Yannick Nicolas Gerber et al.   Frontiers in Cellular Neuroscience

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

(2017) Pavel Klein et al.   EPILEPSIA

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

(2017) Gaetano Terrone et al.   EPILEPSIA

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Microglial positron emission tomography (PET) imaging in epilepsy: Applications, opportunities and pitfalls

(2017) Gregory Scott et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex

(2016) Bo Zhang et al.   EPILEPSIA

Minocycline fails to exert antiepileptogenic effects in a rat status epilepticus model

(2016) Vera Russmann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves

(2016) Anna Martínez-Muriana et al.   Scientific Reports

Candidate Drug Targets for Prevention or Modification of Epilepsy

(2015) Nicholas H. Varvel et al.   Annual Review of Pharmacology and Toxicology

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

(2015) Melissa J. Benson et al.   EPILEPSIA

Role of fractalkine–CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain

(2015) Idrish Ali et al.   NEUROBIOLOGY OF DISEASE

Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus

(2015) N. Wang et al.   NEUROSCIENCE

Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction

(2015) Anne-Laure Leblond et al.   PLoS One

Epileptogenesis

(2015) Asla Pitkänen et al.   Cold Spring Harbor Perspectives in Medicine

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

(2015) Leah D. Gershen et al.   JAMA Neurology

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Involvement of P2X4 receptors in hippocampal microglial activation afterstatus epilepticus

(2013) Lauriane Ulmann et al.   GLIA

Lateral entorhinal cortex is critical for novel object-context recognition

(2013) David I.G. Wilson et al.   HIPPOCAMPUS

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis

(2011) Oliver Crespo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus

(2011) S.-I. Yeo et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

(2010) Martine M. Mirrione et al.   NEUROBIOLOGY OF DISEASE

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

Definition of refractory epilepsy: defining the indefinable?

(2009) Patrick Kwan et al.   LANCET NEUROLOGY

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE