Two hit mitochondrial-driven model of synapse loss in neurodegeneration

Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates

(2020) Hao Jiang et al.   Scientific Reports

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

(2020) Abhishek Jauhari et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular resolution imaging by post-labeling expansion single-molecule localization microscopy (Ex-SMLM)

(2020) Fabian U. Zwettler et al.   Nature Communications

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson’s Disease

(2019) Paola Imbriani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of human limb muscles based on whole-mount immunostaining and the links between ontogeny and evolution

(2019) Rui Diogo et al.   DEVELOPMENT

A super-resolution platform for correlative live single-molecule imaging and STED microscopy

(2019) V. V. G. Krishna Inavalli et al.   NATURE METHODS

α-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice

(2018) Nicholas Maxwell et al.   AGING CELL

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

(2018) Balázs A. Györffy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

(2018) Eleanor K. Pickett et al.   ACTA NEUROPATHOLOGICA

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Mitochondria modulate programmed neuritic retraction

(2018) Sergei V. Baranov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease

(2018) Sandra Franco-Iborra et al.   Cell Death & Disease

Synaptic Mitochondria Sustain More Damage than Non-Synaptic Mitochondria after Traumatic Brain Injury and Are Protected by Cyclosporine A

(2017) Jacqueline R. Kulbe et al.   JOURNAL OF NEUROTRAUMA

Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor

(2017) Bharati Sinha et al.   JOURNAL OF PINEAL RESEARCH

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function

(2016) Kelly L. Stauch et al.   Aging-US

Characterization of Social Behaviors in caspase-3 deficient mice

(2016) Shih-Ching Lo et al.   Scientific Reports

Caspase-3 Deficiency Results in Disrupted Synaptic Homeostasis and Impaired Attention Control

(2015) S.-C. Lo et al.   JOURNAL OF NEUROSCIENCE

Synaptic mitochondria: A brain mitochondria cluster with a specific proteome

(2015) Katalin Völgyi et al.   Journal of Proteomics

Melatonin: Physiological effects in humans

(2015) B. Claustrat et al.   NEUROCHIRURGIE

New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles

(2015) Nicolas Unsain et al.   NEURON

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Quantitative Proteomics of Synaptic and Nonsynaptic Mitochondria: Insights for Synaptic Mitochondrial Vulnerability

(2014) Kelly L. Stauch et al.   JOURNAL OF PROTEOME RESEARCH

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Plasma melatonin is reduced in Huntington's disease

(2014) Eirini Kalliolia et al.   MOVEMENT DISORDERS

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Disturbances in melatonin secretion and circadian sleep–wake regulation in Parkinson disease

(2014) S.J. Bolitho et al.   SLEEP MEDICINE

Circadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease

(2014) Aleksandar Videnovic et al.   JAMA Neurology

MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

(2013) Andrew W Ferree et al.   Autophagy

Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

(2013) Ketan Malhotra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Yi Zhang et al.   NEUROBIOLOGY OF DISEASE

Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment

(2013) Y. Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in axonal and dendritic degeneration

(2013) Yi Yang et al.   TRENDS IN NEUROSCIENCES

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

(2011) X. Wang et al.   JOURNAL OF NEUROSCIENCE

The Role of Microglia in Synaptic Stripping and Synaptic Degeneration: A Revised Perspective

(2010) V Hugh Perry et al.   ASN Neuro

Gene disruption of caspase-3 prevents MPTP-induced Parkinson’s disease in mice

(2010) Marina Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

(2010) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Neuronal caspase-3 signaling: not only cell death

(2009) M D'Amelio et al.   CELL DEATH AND DIFFERENTIATION

Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease

(2009) N. Ahmad Aziz et al.   JOURNAL OF NEUROLOGY

Methazolamide and Melatonin Inhibit Mitochondrial Cytochrome C Release and Are Neuroprotective in Experimental Models of Ischemic Injury

(2009) Xin Wang et al.   STROKE

Brain mitochondrial dysfunction in aging

(2008) Alberto Boveris et al.   IUBMB LIFE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON