Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma

The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2

(2021) Tracy J Berg et al.   CANCER RESEARCH

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

(2021) Xing Yi Woo et al.   NATURE GENETICS

Single-cell chromatin accessibility profiling of glioblastoma identifies an Invasive cancer stem cell population associated with lower survival

(2021) Paul Guilhamon et al.   eLife

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

(2021) Erik Jung et al.   Nature Communications

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition

(2021) Michela Serresi et al.   Science Advances

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

(2021) Toshiro Hara et al.   CANCER CELL

Cycling cancer persister cells arise from lineages with distinct programs

(2021) Yaara Oren et al.   NATURE

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

(2021) David N Louis et al.   NEURO-ONCOLOGY

Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches

(2021) Punit Saraon et al.   ONCOGENE

Long non-coding RNAs in cancer stem cells

(2021) Melanie Schwerdtfeger et al.   Translational Oncology

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

(2021) Kevin C. Johnson et al.   NATURE GENETICS

Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

(2021) Ronan Chaligne et al.   NATURE GENETICS

Clonal ZEB1-driven mesenchymal transition promotes targetable oncologic anti-angiogenic therapy resistance

(2020) Ankush Chandra et al.   CANCER RESEARCH

Towards Multidrug Adaptive Therapy

(2020) Jeffrey West et al.   CANCER RESEARCH

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma

(2020) Aparna Bhaduri et al.   Cell Stem Cell

Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma

(2020) Yolanda Pires-Afonso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance

(2020) Andriy Marusyk et al.   CANCER CELL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma

(2020) Parvez Vora et al.   Cell Stem Cell

Tumor microenvironment is critical for the maintenance of cellular states found in primary glioblastomas.

(2020) Allison R Pine et al.   Cancer Discovery

Cell Lineage-Based Stratification for Glioblastoma

(2020) Zilai Wang et al.   CANCER CELL

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

(2020) Leila Akkari et al.   Science Translational Medicine

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

(2020) Charles P. Couturier et al.   Nature Communications

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

(2020) Anna Golebiewska et al.   ACTA NEUROPATHOLOGICA

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

(2020) Soniya Bastola et al.   Nature Communications

Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma

(2020) Sabrina Fritah et al.   Cancers

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

(2020) Michael Weller et al.   Nature Reviews Clinical Oncology

Tumor cell network integration in glioma represents a stemness feature

(2020) Ruifan Xie et al.   NEURO-ONCOLOGY

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

(2020) Yonghe Wu et al.   Nature Communications

Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy

(2020) Eliane Klein et al.   Frontiers in Oncology

Intra-Tumor DNA Methylation Heterogeneity in Glioblastoma; Implications for DNA Methylation-Based Classification

(2019) Anna Wenger et al.   NEURO-ONCOLOGY

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

(2019) Mutsuko Minata et al.   Cell Reports

Resolving genetic heterogeneity in cancer

(2019) Samra Turajlic et al.   NATURE REVIEWS GENETICS

Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

(2019) Verena Körber et al.   CANCER CELL

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

(2019) Anne Dirkse et al.   Nature Communications

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

(2019) Patricia Rusu et al.   Cell Stem Cell

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

The phenotypes of proliferating glioblastoma cells reside on a single axis of variation

(2019) Lin Wang et al.   Cancer Discovery

Longitudinal molecular trajectories of diffuse glioma in adults

(2019) Floris P. Barthel et al.   NATURE

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma

(2019) Rohit Sachdeva et al.   Scientific Reports

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

(2019) Rachael A. Vaubel et al.   CLINICAL CANCER RESEARCH

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

(2019) Shensi Shen et al.   Nature Communications

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells

(2018) Amelia Weber Hall et al.   CANCER RESEARCH

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

(2018) Xiuxing Wang et al.   Cell Stem Cell

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

(2018) Ana C. deCarvalho et al.   NATURE GENETICS

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

(2018) et al.   NEURO-ONCOLOGY

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

(2018) Mariella G. Filbin et al.   SCIENCE

A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence

(2018) Camila Ferreira de Souza et al.   Cell Reports

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

(2018) Tyler Risom et al.   Nature Communications

Evolutionary dynamics of residual disease in human glioblastoma

(2018) I Spiteri et al.   ANNALS OF ONCOLOGY

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

A non-hierarchical organization of tumorigenic NG2 cells in glioblastoma promoted by EGFR

(2018) Talal F Al-Mayhani et al.   NEURO-ONCOLOGY

DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

(2018) Chaoyang Ye et al.   Nature Communications

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

(2017) Tyler E. Miller et al.   NATURE

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

(2017) Xiaoyang Lan et al.   NATURE

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

(2017) Andrew S. Venteicher et al.   SCIENCE

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Expression of CD133 and CD44 in glioblastoma stem cells correlates with cell proliferation, phenotype stability and intra-tumor heterogeneity

(2017) Daniel V. Brown et al.   PLoS One

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma

(2016) Wei Wei et al.   CANCER CELL

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

(2016) Roman Reinartz et al.   CLINICAL CANCER RESEARCH

DNA repair mechanisms and their clinical impact in glioblastoma

(2016) Hélène Erasimus et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

(2016) Anna Segerman et al.   Cell Reports

Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells

(2016) Arlet M. Acanda de la Rocha et al.   PLoS One

Spatiotemporal Evolution of the Primary Glioblastoma Genome

(2015) Jinkuk Kim et al.   CANCER CELL

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD15 Expression Does Not Identify a Phenotypically or Genetically Distinct Glioblastoma Population

(2015) Emma Kenney-Herbert et al.   Stem Cells Translational Medicine

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

(2014) Fred Fack et al.   ACTA NEUROPATHOLOGICA

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy

(2014) K. Yan et al.   GENES & DEVELOPMENT

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

(2014) H Lopez-Bertoni et al.   ONCOGENE

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

(2014) P Dahan et al.   Cell Death & Disease

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

(2014) J V Joseph et al.   Cell Death & Disease

Sox2 Promotes Malignancy in Glioblastoma by Regulating Plasticity and Astrocytic Differentiation

(2014) Artem D. Berezovsky et al.   NEOPLASIA

Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes

(2013) Daniel Stieber et al.   ACTA NEUROPATHOLOGICA

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells

(2013) Anna Golebiewska et al.   BRAIN

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

Multiplex mapping of chromatin accessibility and DNA methylation within targeted single molecules identifies epigenetic heterogeneity in neural stem cells and glioblastoma

(2013) N. H. Nabilsi et al.   GENOME RESEARCH

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype

(2013) Shaun D. Fouse et al.   NEURO-ONCOLOGY

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

(2013) David A. Nathanson et al.   SCIENCE

CD133 Is Essential for Glioblastoma Stem Cell Maintenance

(2013) Paola Brescia et al.   STEM CELLS

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

(2012) Lindy E. Barrett et al.   CANCER CELL

MET Signaling Regulates Glioblastoma Stem Cells

(2012) K. M. Joo et al.   CANCER RESEARCH

Cancer Stem Cells: Distinct Entities or Dynamically Regulated Phenotypes?

(2012) Y. Li et al.   CANCER RESEARCH

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Aberrant Expression of Retinoic Acid Signaling Molecules Influences Patient Survival in Astrocytic Gliomas

(2011) Benito Campos et al.   AMERICAN JOURNAL OF PATHOLOGY

Critical Appraisal of the Side Population Assay in Stem Cell and Cancer Stem Cell Research

(2011) Anna Golebiewska et al.   Cell Stem Cell

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

(2011) Dagmar Beier et al.   Molecular Cancer

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

(2010) Ruihuan Chen et al.   CANCER CELL

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

Side Population is Not Necessary or Sufficient for a Cancer Stem Cell Phenotype in Glioblastoma Multiforme

(2010) Kate W. R. Broadley et al.   STEM CELLS

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Cancer stem cells and angiogenesis

(2009) Rolf Bjerkvig et al.   SEMINARS IN CANCER BIOLOGY

Epigenetic Landscaping During hESC Differentiation to Neural Cells

(2009) Anna Golebiewska et al.   STEM CELLS

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

IDENTIFICATION OF A2B5+CD133− TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS

(2008) Alfred T. Ogden et al.   NEUROSURGERY

CD133 Is a Marker of Bioenergetic Stress in Human Glioma

(2008) Corinne E. Griguer et al.   PLoS One

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

(2007) Jian Wang et al.   INTERNATIONAL JOURNAL OF CANCER