Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia

Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury

(2020) Qi Han et al.   Cell Metabolism

Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction?

(2020) Robert N Lightowlers et al.   EMBO REPORTS

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

(2019) Ashley L. Kalinski et al.   JOURNAL OF CELL BIOLOGY

Somatic autophagy of axonal mitochondria in ischemic neurons

(2019) Yanrong Zheng et al.   JOURNAL OF CELL BIOLOGY

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons

(2018) Alessio Vagnoni et al.   CURRENT BIOLOGY

Axonal mRNA transport and translation at a glance

(2018) Pabitra K. Sahoo et al.   JOURNAL OF CELL SCIENCE

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury

(2018) Qi Luan et al.   MEDICAL SCIENCE MONITOR

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience

(2017) Marco Terenzio et al.   NEURON

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

(2017) Zu-Hang Sheng   TRENDS IN CELL BIOLOGY

A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy

(2017) Yusuke Fukuda et al.   Frontiers in Neuroscience

A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity

(2017) Romain Cartoni et al.   PLoS One

Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation

(2016) Héctor Diez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

Mitochondrial Dynamics in Visual Cortex Are Limited In Vivo and Not Affected by Axonal Structural Plasticity

(2016) Laura Smit-Rigter et al.   CURRENT BIOLOGY

Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo

(2016) Tommy L. Lewis et al.   CURRENT BIOLOGY

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration

(2016) Romain Cartoni et al.   NEURON

Mitochondria Localize to Injured Axons to Support Regeneration

(2016) Sung Min Han et al.   NEURON

Mitochondrial Mobility and Neuronal Recovery

(2016) Allen Kaasik   NEW ENGLAND JOURNAL OF MEDICINE

GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

(2016) Xinzheng Guo et al.   eLife

Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway

(2015) BIN XIA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Kinase-interacting substrate screening is a novel method to identify kinase substrates

(2015) Mutsuki Amano et al.   JOURNAL OF CELL BIOLOGY

Direct visualization of newly synthesized target proteins in situ

(2015) Susanne tom Dieck et al.   NATURE METHODS

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

(2015) Yuji Takihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axons Degenerate in the Absence of Mitochondria in C. elegans

(2014) Randi L. Rawson et al.   CURRENT BIOLOGY

In vivo introduction of transgenes into mouse sciatic nerve cells in situ using viral vectors

(2014) Sergio Gonzalez et al.   Nature Protocols

Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons

(2014) V Cavallucci et al.   Cell Death & Disease

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

WldS and PGC-1  Regulate Mitochondrial Transport and Oxidation State after Axonal Injury

(2013) K. C. O'Donnell et al.   JOURNAL OF NEUROSCIENCE

Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength

(2013) Tao Sun et al.   Cell Reports

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Global Identification and Characterization of BothO-GlcNAcylation and Phosphorylation at the Murine Synapse

(2012) Jonathan C. Trinidad et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

(2012) Frank Bradke et al.   NATURE REVIEWS NEUROSCIENCE

Concepts and Methods for the Study of Axonal Regeneration in the CNS

(2012) Mark H. Tuszynski et al.   NEURON

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Specific Roles of Akt iso Forms in Apoptosis and Axon Growth Regulation in Neurons

(2012) Hector Diez et al.   PLoS One

Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking

(2012) T. I. Strochlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

(2012) H. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+Regulation of Mitochondrial ATP Synthesis Visualized at the Single Cell Level

(2011) Masahiro Nakano et al.   ACS Chemical Biology

The emerging importance of group II PAKs

(2010) Claire M. Wells et al.   BIOCHEMICAL JOURNAL

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

The diffusive interaction of microtubule binding proteins

(2009) Jeremy R Cooper et al.   CURRENT OPINION IN CELL BIOLOGY

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Mitochondrial Targets for Stroke

(2009) Peter S. Vosler et al.   STROKE

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress

(2008) C. Press et al.   JOURNAL OF NEUROSCIENCE

Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons

(2008) Sigeng Chen et al.   PLoS One

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Axonal growth therapeutics: regeneration or sprouting or plasticity?

(2008) William B.J. Cafferty et al.   TRENDS IN NEUROSCIENCES