Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2

Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia

(2021) Ning Huang et al.   CURRENT BIOLOGY

Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury

(2020) Qi Han et al.   Cell Metabolism

SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair

(2020) Manchao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Oligodendrocytes support axonal transport and maintenance via exosome secretion

(2020) Carsten Frühbeis et al.   PLOS BIOLOGY

Mechanisms for the maintenance and regulation of axonal energy supply

(2019) Kelly Anne Chamberlain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effective Visualization and Easy Tracking of Extracellular Vesicles in Glioma Cells

(2019) Abir Mondal et al.   BIOLOGICAL PROCEDURES ONLINE

Inhibition of SIRT2 by Targeting GSK3β-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells

(2019) Shuhu Liu et al.   Frontiers in Cellular Neuroscience

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers

(2019) Isaac Kirubakaran Sundar et al.   Journal of Extracellular Vesicles

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

(2019) Mariadelva Catalano et al.   Journal of Extracellular Vesicles

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Oligodendrocytes in the Mouse Corpus Callosum Maintain Axonal Function by Delivery of Glucose

(2018) Niklas Meyer et al.   Cell Reports

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2

(2017) Katja A. Lüders et al.   GLIA

Astrocytes Provide Metabolic Support for Neuronal Synaptic Function in Response to Extracellular K+

(2017) Brian A. MacVicar et al.   NEUROCHEMICAL RESEARCH

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

(2017) Zu-Hang Sheng   TRENDS IN CELL BIOLOGY

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

(2017) Nicolas Snaidero et al.   Cell Reports

Monitoring ATP dynamics in electrically active white matter tracts

(2017) Andrea Trevisiol et al.   eLife

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

(2017) Natalia Salvadores et al.   Frontiers in Neuroscience

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

(2017) Dequina Nicholas et al.   PLoS One

A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity

(2016) Hui Jing et al.   CANCER CELL

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

Extracellular vesicles: interneural shuttles of complex messages

(2016) Eva-Maria Krämer-Albers et al.   CURRENT OPINION IN NEUROBIOLOGY

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

(2016) Xinghua Yin et al.   JOURNAL OF CELL BIOLOGY

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis

(2016) Kelly A. Chamberlain et al.   NEUROPHARMACOLOGY

Mechanisms and Dynamics of Protein Acetylation in Mitochondria

(2016) Josue Baeza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System

(2016) T. Jayasena et al.   Scientific Reports

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc− Mediates Aglycemic Neuronal Cell Death

(2015) Trista L. Thorn et al.   ASN Neuro

The contributions of respiration and glycolysis to extracellular acid production

(2015) Shona A. Mookerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

(2015) Benjamin Ettle et al.   MOLECULAR NEUROBIOLOGY

Adenine Nucleotide Translocase Is Acetylated in Vivo in Human Muscle: Modeling Predicts a Decreased ADP Affinity and Altered Control of Oxidative Phosphorylation

(2014) Clinton Mielke et al.   BIOCHEMISTRY

Mitochondrial protein acetylation regulates metabolism

(2014) Kristin A. Anderson et al.   Essays in Biochemistry

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

(2014) D. Frohlich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons

(2014) Nobuhiko Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy Failure

(2013) Divya Pathak et al.   ANNALS OF NEUROLOGY

SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress

(2013) Athanassios Vassilopoulos et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of myelin and oligodendrocytes in axonal energy metabolism

(2013) Aiman S Saab et al.   CURRENT OPINION IN NEUROBIOLOGY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength

(2013) Tao Sun et al.   Cell Reports

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Targeted Ablation of Oligodendrocytes Induces Axonal Pathology Independent of Overt Demyelination

(2012) L.-J. Oluich et al.   JOURNAL OF NEUROSCIENCE

Isolation of cortical mouse oligodendrocyte precursor cells

(2012) Toros A. Dincman et al.   JOURNAL OF NEUROSCIENCE METHODS

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

(2012) Alicia Lundby et al.   Cell Reports

Ca2+Regulation of Mitochondrial ATP Synthesis Visualized at the Single Cell Level

(2011) Masahiro Nakano et al.   ACS Chemical Biology

Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis

(2011) Jessica L. Zambonin et al.   BRAIN

The QKI-PLP pathway controls SIRT2 abundance in CNS myelin

(2011) H. Zhu et al.   GLIA

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

Oligodendrocytes as Regulators of Neuronal Networks during Early Postnatal Development

(2011) Sandrine Doretto et al.   PLoS One

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease

(2010) Julia M. Edgar et al.   EMBO Molecular Medicine

Demyelination Increases Axonal Stationary Mitochondrial Size and the Speed of Axonal Mitochondrial Transport

(2010) S. Kiryu-Seo et al.   JOURNAL OF NEUROSCIENCE

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial changes within axons in multiple sclerosis

(2009) D. J. Mahad et al.   BRAIN

Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression ofCnp1

(2009) Julia M. Edgar et al.   GLIA

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced number and activity of mitochondria in multiple sclerosis lesions

(2009) Maarten E Witte et al.   JOURNAL OF PATHOLOGY

Axon-Glial Signaling and the Glial Support of Axon Function

(2008) Klaus-Armin Nave et al.   Annual Review of Neuroscience

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL