The regulation of neuronal mitochondrial metabolism by calcium

CCDC90A (MCUR1) Is a Cytochrome c Oxidase Assembly Factor and Not a Regulator of the Mitochondrial Calcium Uniporter

(2015) Vincent Paupe et al.   Cell Metabolism

Unresolved questions from the analysis of mice lacking MCU expression

(2014) Elizabeth Murphy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional impact of glycogen degradation on astrocytic signalling: Figure 1

(2014) Margit S. Müller   BIOCHEMICAL SOCIETY TRANSACTIONS

Ca2+ regulation of mitochondrial function in neurons

(2014) Carlos B. Rueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

The elusive importance of being a mitochondrial Ca2+ uniporter

(2014) Diana Pendin et al.   CELL CALCIUM

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation

(2014) Patrick J. Doonan et al.   FASEB JOURNAL

Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis

(2014) Margit S. Müller et al.   GLIA

NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State

(2014) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

(2014) Isabel Saez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The destiny of Ca2+ released by mitochondria

(2014) Ayako Takeuchi et al.   Journal of Physiological Sciences

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Impulse Conduction Increases Mitochondrial Transport in Adult Mammalian Peripheral Nerves In Vivo

(2014) Marija Sajic et al.   PLOS BIOLOGY

Effect of Calcium on the Oxidative Phosphorylation Cascade in Skeletal Muscle Mitochondria

(2013) Brian Glancy et al.   BIOCHEMISTRY

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

The control of brain mitochondrial energization by cytosolic calcium: The mitochondrial gas pedal

(2013) Frank Norbert Gellerich et al.   IUBMB LIFE

Glucagon Regulation of Oxidative Phosphorylation Requires an Increase in Matrix Adenine Nucleotide Content through Ca2+Activation of the Mitochondrial ATP-Mg/PiCarrier SCaMC-3

(2013) Ignacio Amigo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional reconstitution of the mitochondrial Ca2+/H+antiporter Letm1

(2013) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

NCLX: The mitochondrial sodium calcium exchanger

(2013) Liron Boyman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

(2013) I. Llorente-Folch et al.   JOURNAL OF NEUROSCIENCE

The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications

(2013) Saverio Marchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Mitochondrial Ca2+ uniporter (MCU)-dependent and MCU-independent Ca2+ channels coexist in the inner mitochondrial membrane

(2013) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of distinct single-channel properties of Ca2+ inward currents in mitochondria

(2013) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome

(2013) D. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

Cytosolic Ca2+regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle

(2012) Frank Norbert Gellerich et al.   BIOCHEMICAL JOURNAL

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

The interplay of mitochondria with calcium: An historical appraisal

(2012) Ernesto Carafoli   CELL CALCIUM

The Pathophysiology of LETM1

(2012) Karin Nowikovsky et al.   JOURNAL OF GENERAL PHYSIOLOGY

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

(2012) Jeffrey D Martell et al.   NATURE BIOTECHNOLOGY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons

(2011) R. G. Whittaker et al.   BRAIN

SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca2+ buffering

(2011) J Traba et al.   CELL DEATH AND DIFFERENTIATION

Adenine nucleotide transporters in organelles: novel genes and functions

(2011) Javier Traba et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

After half a century mitochondrial calcium in- and efflux machineries reveal themselves

(2011) Ilaria Drago et al.   EMBO JOURNAL

Activity-dependent Increases in Local Oxygen Consumption Correlate with Postsynaptic Currents in the Mouse Cerebellum In Vivo

(2011) C. Mathiesen et al.   JOURNAL OF NEUROSCIENCE

Modulation of the mitochondrial permeability transition by cyclophilin D: Moving closer to F0–F1 ATP synthase?

(2011) Christos Chinopoulos et al.   MITOCHONDRION

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Mitochondrial Free [Ca2+] Increases during ATP/ADP Antiport and ADP Phosphorylation: Exploration of Mechanisms

(2010) Johan Haumann et al.   BIOPHYSICAL JOURNAL

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

(2010) Shin-Young Ryu et al.   FEBS LETTERS

Brain Glutamine Synthesis Requires Neuronal-Born Aspartate as Amino Donor for Glial Glutamate Formation

(2010) Beatriz Pardo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alterations in bioenergetics due to changes in mitochondrial DNA copy number

(2010) Wei Qian et al.   METHODS

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria

(2010) I. N. Watt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characteristics and possible functions of mitochondrial Ca2+ transport mechanisms

(2009) Thomas E. Gunter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of Ca2+ signaling in the coordination of mitochondrial ATP production with cardiac work

(2009) Robert S. Balaban   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

IF1: setting the pace of the F1Fo-ATP synthase

(2009) Michelangelo Campanella et al.   TRENDS IN BIOCHEMICAL SCIENCES

The ADP and ATP transport in mitochondria and its carrier

(2008) Martin Klingenberg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Yeast mitochondria import ATP through the calcium-dependent ATP-Mg/Pi carrier Sal1p, and are ATP consumers during aerobic growth in glucose

(2008) Javier Traba et al.   MOLECULAR MICROBIOLOGY

Mitochondria: The Hub of Cellular Ca2+ Signaling

(2008) György Szabadkai et al.   PHYSIOLOGY