FoxO integration of insulin signaling with glucose and lipid metabolism

Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets

(2017) Adam J. Dobson et al.   Cell Reports

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

(2016) Hagoon Jang et al.   Nature Communications

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice

(2015) Virtu Calabuig-Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AssessingFOXO1Aas a potential susceptibility locus for type 2 diabetes and obesity in American Indians

(2015) Yunhua L. Muller et al.   Obesity

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

FoxO6 Integrates Insulin Signaling With MTP for Regulating VLDL Production in the Liver

(2014) Dae Hyun Kim et al.   ENDOCRINOLOGY

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

(2014) Michael M. Mueller et al.   NATURE CELL BIOLOGY

FoxO6 and PGC-1α form a regulatory loop in myogenic cells

(2013) Shih Ying Chung et al.   BIOSCIENCE REPORTS

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Hepatic Insulin Resistance, VLDL Overproduction, and Hypertriglyceridemia

(2012) Janet D. Sparks et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FoxO6 regulates memory consolidation and synaptic function

(2012) D. A. M. Salih et al.   GENES & DEVELOPMENT

FOXO1 Mediates the Autocrine Effect of Endothelin-1 on Endothelial Cell Survival

(2012) Vincenza Cifarelli et al.   MOLECULAR ENDOCRINOLOGY

Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans

(2011) Rabea Kleindorp et al.   AGING CELL

FoxO1 integrates insulin signaling to VLDL production

(2011) Adama Kamagate et al.   CELL CYCLE

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver

(2011) Dae Hyun Kim et al.   DIABETES

Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance

(2011) Sung Hee Choi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data

(2010) Mette Soerensen et al.   AGING CELL

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

FoxO gene family evolution in vertebrates

(2009) Minghui Wang et al.   BMC EVOLUTIONARY BIOLOGY

FoxO1 and hepatic lipid metabolism

(2009) Janet D Sparks et al.   CURRENT OPINION IN LIPIDOLOGY

Current strategies for the inhibition of hepatic glucose production in type 2 diabetes

(2009) Dale et al.   Frontiers in Bioscience-Landmark

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

(2009) Yang Li et al.   HUMAN MOLECULAR GENETICS

Association of Common Genetic Variation in theFOXO1Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, and Type 2 Diabetes

(2009) Karsten Müssig et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice

(2009) Tsuyoshi Chiba et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study

(2009) Chiara Viviani Anselmi et al.   REJUVENATION RESEARCH

Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP

(2009) T. Monecke et al.   SCIENCE

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression

(2008) Satomi Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

(2008) Adama Kamagate et al.   JOURNAL OF CLINICAL INVESTIGATION

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

(2008) Michael M. Brent et al.   STRUCTURE