Article
Food Science & Technology
Sanja Kostic, Aleksandra Vilotic, Andrea Pirkovic, Dragana Dekanski, Suncica Borozan, Mirjana Nacka-Aleksic, Svetlana Vrzic-Petronijevic, Milica Jovanovic Krivokuca
Summary: This study investigated the cytoprotective effects of caffeic acid on first trimester extravillous trophoblast cells. The results showed that caffeic acid had no cytotoxic effects and could attenuate oxidative damage, reduce cytotoxicity and lipid peroxidation, and restore antioxidant capacity in trophoblast cells.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Engineering, Multidisciplinary
Hyun Jeong Won, Tae Min Kim, In-sook An, Heung Jin Bae, Sung Young Park
Summary: In this study, a hair-coating polyphenol complex (PPC) was developed with ultraviolet (UV) protection properties, antistatic features, and the ability to enhance the mechanical strength of damaged hair. Different ratios of tannic acid (TA), gallic acid (GA), and caffeic acid (CA) in PPCs increased the self-recovery of damaged hair by protecting the cuticle. PPC prevented light transmission through damaged hair during UV radiation exposure. Surfaces coated with PPC1 (100:20:0.5) exhibited higher conductivity and antistatic performance, with a resistance of 0.72 MΩ. Coating damaged hair with a PPC1-containing shampoo increased durability and elasticity, with a tensile strain of up to 2.06x, indicating recovery of the damaged cuticle. PPC1-containing shampoo also prevented damage by scavenging excess reactive oxygen species in the hair. The natural PPC combination effect offers new insights into hair treatment and hair restoration technology.
Article
Oncology
Xinmiao Wang, Weinian Liao, Jun Chen, Yiding Wu, Chaonan Liu, Shilei Chen, Yang Xu, Song Wang, Yongping Su, Changhong Du, Junping Wang
Summary: Mitochondrial oxidative damage is rapidly induced in hematopoietic stem cells (HSCs) after exposure to ionizing radiation, leading to apoptosis. The induction of 5-lipoxygenase (5-LOX) plays a key role in this process, while the natural antioxidant caffeic acid (CA) can protect against HSC apoptosis by suppressing 5-LOX-mediated mitochondrial oxidative damage.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nada Orsolic, Damir Sirovina, Dyana Odeh, Goran Gajski, Vedran Balta, Lidija Sver, Maja Jazvinscak Jembrek
Summary: The study showed that caffeic acid has protective effects on the liver and kidney of diabetic mice, reduces blood sugar and lipids, decreases the occurrence of atherosclerosis, and extends the lifespan of mice.
Article
Biochemistry & Molecular Biology
Meltem Kolgazi, Sumeyye Cilingir, Ozgur Yilmaz, Merve Gemici, Hasan Yazar, Samed Ozer, Merve Acikel-Elmas, Serap Arbak, Guldal Gulec Suyen
Summary: The study found that caffeic acid can ameliorate ethanol-induced gastric mucosal damage, with the nitric oxide pathway contributing to this effect but a lack of evidence for the muscarinic cholinergic system's contribution.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Food Science & Technology
Rili Hao, Yang Jiang, Feng Li, Dongxiao Sun-Waterhouse, Dapeng Li
Summary: The study demonstrated that CAPE mitigates CdCl2-induced spleen damage by reducing spleen weight and Cd content, and by regulating inflammation and apoptosis pathways. The protective effect is achieved through the miR-182-5p/TLR4/NF-κB axis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Milan Rancic, Lidija Ristic, Andrija Rancic, Dane Krtinic, Bojan Ilic, Milorad Pavlovic, Milos Milojkovic, Nikola Zivkovic, Dusan Sokolovic
Summary: The study showed that cisplatin induced significant damage in rat lung tissue, including oxidative damage and cell apoptosis. Both LCP and CAPE were able to mitigate these damages to a certain extent, but had limited effect on inflammation.
Article
Food Science & Technology
Nana Baah Pepra-Ameyaw, Christine Lo Verde, Charles T. Drucker, Cedric P. Owens, Lilian W. Senger
Summary: Two methods were presented to prevent greening in sunflower cookies: adding free thiols from cysteine and glutathione, and hydrolyzing chlorogenic acid (CGA) into caffeic acid and quinic acid using a CGA esterase. Cysteine had a slower reaction, and neither cysteine nor glutathione prevented greening during storage. CGA esterase effectively eliminated greening by hydrolyzing CGA in sunflower butter and flour. The enzyme could be directly applied to the dough, making the process efficient and allowing the use of sunflower butter and flour in neutrally colored baked products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Neurosciences
Mara Yone D. Fernandes, Joao Pedro Lopes, Henrique B. Silva, Geanne M. Andrade, Rodrigo A. Cunha, Angelo R. Tome
Summary: Caffeic acid, a polyphenolic compound found in many dietary components, has been shown to reduce brain ischemia and attenuate various brain diseases. This study investigated whether caffeic acid directly affects synaptic transmission and plasticity, and found that it does not have a direct effect but can indirectly correct synaptic dysfunction.
NEUROSCIENCE LETTERS
(2023)
Article
Immunology
Chang-meng Yu, Yi Wang, Shi-chun Ren, Zhi-li Liu, Cheng-long Zhu, Qiang Liu, Hui-ru Li, Chen-yan Sun, Xiao-yang Sun, Jian Xie, Jia-feng Wang, Xiao-ming Deng
Summary: The study found that CA treatment can improve the 7-day survival rate and alleviate histopathological injury in the lungs and livers of CLP mice. CA can significantly reduce neutrophil infiltration in the lungs and livers of CLP mice. While vehicle partially reduced the levels of MDA, TNF-alpha, IL-1 beta, and IL-6, CA further decreased their levels and inhibited the phosphorylation of MAPK and NF-kappa B induced by LPS. CA treatment further increased the levels of HO-1 and enhanced SOD activity but reduced MDA levels and NET formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shuopeng Yang, Yanzhen Han, Kairui Wang, Yu Wang, Liping Li, Nan Li, Xiangdong Xu
Summary: A CE-CL method was developed for the simultaneous determination of four phenolic acids found in traditional Chinese medicine, demonstrating high sensitivity and reliability.
Article
Biochemistry & Molecular Biology
Mang Xiao, Xianghong Li, Li Wang, Bin Lin, Min Zhai, Lisa Hull, Alex Zizzo, Wanchang Cui, Juliann G. Kiang
Summary: This study evaluated the inflammatory responses induced by radiation injury and radiation combined with skin injury in the mouse brain. The results showed that radiation combined with skin injury caused more severe animal death and body weight loss compared to radiation alone, and delayed wound healing. Furthermore, both radiation alone and combined with skin injury activated astrocytes and endothelial cells, leading to blood-brain barrier leakage and neural cell damage. These findings suggest that inflammatory pathways play a role in brain injury induced by radiation combined with skin injury, with the latter exacerbating neural cell damage more than radiation alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Miao Cai, Jiayu Liu, Xiaofei Song, Hang Qi, Yuanzi Li, Zhenzhou Wu, Haijin Xu, Mingqiang Qiao
Summary: This study achieved the de novo biosynthesis of p-coumaric acid and caffeic acid from lignocellulose through a co-cultivation strategy. The improved inoculation ratio and carbon source content significantly increased the production yield of these aromatic compounds.
MICROBIAL CELL FACTORIES
(2022)
Article
Chemistry, Inorganic & Nuclear
Masoomeh Nazari, Raheleh Safaeijavan, Ali Vaziri Yazdi, Elham Moniri
Summary: This study compared the effects of different fatty acid-modified chitosan surfaces as nanocarriers for targeted delivery of the anticancer drug methotrexate (MTX) in vitro. The surface modification of chitosan with oleic acid (OA) and caffeic acid (CA) was investigated. The results showed that CS-CA had a higher maximum sorption capacity and drug release rate compared to CS-OA. The encapsulation efficiency of MTX from CS-CA was also higher than that of CS-OA.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Iris Rosa Betz, Sarah Julia Qaiyumi, Madeleine Goeritzer, Arne Thiele, Sarah Brix, Niklas Beyhoff, Jana Grune, Robert Klopfleisch, Franziska Greulich, Nina Henriette Uhlenhaut, Ulrich Kintscher, Anna Foryst-Ludwig
Summary: The study demonstrated that C16:1n7 has protective effects on the heart by regulating PPAR-specific signaling pathways and may be used for therapy against cardiac fibrosis and inflammation induced by catecholamines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
