5-Lipoxygenase inhibitors: a review of recent developments and patents

Biological Evaluation of 2-(4-Amino-Phenyl)-3-(3,5-Dihydroxylphenyl) Propenoic Acid

(2009) Guang-Lin Xu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E2 synthase-1

(2009) Andreas Koeberle et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoylclusters

(2009) Jérémie Doiron et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes

(2009) Yilmaz Mahshid et al.   BMC IMMUNOLOGY

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo

(2009) Christian Feißt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis

(2009) Magnus Back   CURRENT PHARMACEUTICAL DESIGN

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

(2009) Andreas Koeberle et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies in vitro and pharmacological relevance

(2009) Ulf Siemoneit et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain

(2009) Luz A. Cortes-Burgos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects and gastrointestinal safety of NNU-hdpa, a novel dual COX/5-LOX inhibitor

(2009) Guang-Lin Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor

(2009) Liwen Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice

(2009) Daniel Poeckel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arylpyrrolizines as Inhibitors of Microsomal Prostaglandin E2Synthase-1 (mPGES-1) or as Dual Inhibitors of mPGES-1 and 5-Lipoxygenase (5-LOX)

(2009) Andy J. Liedtke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Celecoxib Analogues Possessing aN-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity

(2009) Morshed A. Chowdhury et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Optimization and Biological Evaluation of 2-Substituted 5-Hydroxyindole-3-carboxylates as Potent Inhibitors of Human 5-Lipoxygenase

(2009) Eva-Maria Karg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1

(2009) A. Koeberle et al.   MOLECULAR CANCER THERAPEUTICS

5-Oxo-ETE and the OXE receptor

(2009) Gail E. Grant et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Celecoxib inhibits 5-lipoxygenase

(2008) Thorsten J. Maier et al.   BIOCHEMICAL PHARMACOLOGY

Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, OH scavenging and anti-adhesive activities

(2008) Michael Scholz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A novel class of 5-lipoxygenase inhibitors

(2008) Morshed Alam Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

(2008) Morshed Alam Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

(2008) Morshed Alam Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expanding roles for leukotrienes in airway inflammation

(2008) Marc Peters-Golden   CURRENT ALLERGY AND ASTHMA REPORTS

Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor

(2008) R. K. Shirumalla et al.   INFLAMMATION RESEARCH

Phosphorylation of Serine 271 on 5-Lipoxygenase and Its Role in Nuclear Export

(2008) Nicolas Flamand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

(2008) Milos D. Ikonomovic et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Leukotriene modifiers in the treatment of cardiovascular diseases

(2008) Graziano Riccioni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Novel and Potent Inhibitors of 5-Lipoxygenase Product Synthesis Based on the Structure of Pirinixic Acid

(2008) Oliver Werz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

(2008) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors

(2008) A. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

(2008) C. Pergola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors

(2008) G.F. Sud’ina et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

(2008) J EVANS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Licofelone: The answer to unmet needs in osteoarthritis therapy?

(2008) Shrinivas K. Kulkarni et al.   Current Rheumatology Reports