A small and highly sensitive red/far-red optogenetic switch for applications in mammals

Near-infrared optogenetic engineering of photothermal nanoCRISPR for programmable genome editing

(2020) Xiaohong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering light-controllable CAR T cells for cancer immunotherapy

(2020) Ziliang Huang et al.   Science Advances

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

(2019) O Sascha Yousefi et al.   eLife

Multi-input chemical control of protein dimerization for programming graded cellular responses

(2019) Glenna Wink Foight et al.   NATURE BIOTECHNOLOGY

Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins

(2019) Daseuli Yu et al.   NATURE METHODS

A green tea–triggered genetic control system for treating diabetes in mice and monkeys

(2019) Jianli Yin et al.   Science Translational Medicine

Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation

(2018) Krisztina Marosi et al.   FASEB JOURNAL

Optogenetic regulation of engineered cellular metabolism for microbial chemical production

(2018) Evan M. Zhao et al.   NATURE

Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation

(2018) Jiawei Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP+ Reductase Systems Enables Genetically Encoded PhyB Optogenetics

(2018) Phillip Kyriakakis et al.   ACS Synthetic Biology

OptoBase: A Web Platform for Molecular Optogenetics

(2018) Katja Kolar et al.   ACS Synthetic Biology

A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes

(2017) Shuai Xue et al.   MOLECULAR THERAPY

CRISPR–Cas9-based photoactivatable transcription systems to induce neuronal differentiation

(2017) Yuta Nihongaki et al.   NATURE METHODS

Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling

(2017) Youichi Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice

(2017) Jiawei Shao et al.   Science Translational Medicine

At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior

(2017) Nicole A. Repina et al.   Annual Review of Chemical and Biomolecular Engineering

Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160

(2017) Arnaud Perrin et al.   Molecular Therapy-Nucleic Acids

An edible switch for gene therapy

(2016) Xavier M Anguela et al.   NATURE BIOTECHNOLOGY

A bacterial phytochrome-based optogenetic system controllable with near-infrared light

(2016) Andrii A Kaberniuk et al.   NATURE METHODS

Self-adjusting synthetic gene circuit for correcting insulin resistance

(2016) Haifeng Ye et al.   Nature Biomedical Engineering

Predictive Spatiotemporal Manipulation of Signaling Perturbations Using Optogenetics

(2015) Leo Valon et al.   BIOPHYSICAL JOURNAL

Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

(2015) Jesse G. Zalatan et al.   CELL

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

(2015) Lauren R Polstein et al.   Nature Chemical Biology

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins

(2015) Fuun Kawano et al.   Nature Communications

An optogenetic gene expression system with rapid activation and deactivation kinetics

(2014) Laura B Motta-Mena et al.   Nature Chemical Biology

Optogenetic control of chemokine receptor signal and T-cell migration

(2014) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells

(2013) Konrad Müller et al.   NUCLEIC ACIDS RESEARCH

An Evolutionarily Conserved Signaling Mechanism Mediates Far-Red Light Responses in Land Plants

(2013) Anja Possart et al.   PLANT CELL

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

Photoconversion and Nuclear Trafficking Cycles Determine Phytochrome A's Response Profile to Far-Red Light

(2011) Julia Rausenberger et al.   CELL

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Induction of protein-protein interactions in live cells using light

(2009) Masayuki Yazawa et al.   NATURE BIOTECHNOLOGY

Membrane-dependent signal integration by the Ras activator Son of sevenless

(2008) Jodi Gureasko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY