Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling

Strategies for development of optogenetic systems and their applications

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Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

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Optimized second-generation CRY2–CIB dimerizers and photoactivatable Cre recombinase

(2016) Amir Taslimi et al.   Nature Chemical Biology

A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein

(2016) Erik A Rodriguez et al.   NATURE METHODS

The family of phytochrome-like photoreceptors: diverse, complex and multi-colored, but very useful

(2015) Katrin Anders et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Optogenetic control of intracellular signaling pathways

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Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

(2014) Yoshihisa Fujita et al.   FEBS Journal

Illuminating cell signalling with optogenetic tools

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Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

A Bilirubin-Inducible Fluorescent Protein from Eel Muscle

(2013) Akiko Kumagai et al.   CELL

Synthesis of phycocyanobilin in mammalian cells

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Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

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Genome engineering using the CRISPR-Cas9 system

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Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

(2012) Anirudh Prahallad et al.   NATURE

Computational Approaches for Analyzing Information Flow in Biological Networks

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Development of an optimized backbone of FRET biosensors for kinases and GTPases

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Processive phosphorylation of ERK MAP kinase in mammalian cells

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

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Cell Signaling by Receptor Tyrosine Kinases

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Rapid blue-light–mediated induction of protein interactions in living cells

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Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase

(2009) Ghassan J. Maghzal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

(2009) Kosuke Yusa et al.   NATURE METHODS

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

BRAF V600E Disrupts AZD6244-Induced Abrogation of Negative Feedback Pathways between Extracellular Signal-Regulated Kinase and Raf Proteins

(2008) B. B. Friday et al.   CANCER RESEARCH

Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

(2008) Takanari Inoue et al.   PLoS One

Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling

(2008) N. Lerner-Marmarosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA