Multi-input chemical control of protein dimerization for programming graded cellular responses

A Chemically Disrupted Proximity System for Controlling Dynamic Cellular Processes

(2019) Daniel Cunningham-Bryant et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protease inhibitor therapy for hepatitis C virus-infection

(2018) P. de Leuw et al.   EXPERT OPINION ON PHARMACOTHERAPY

A Rapamycin-Activated Caspase 9-Based Suicide Gene

(2018) Maria Stavrou et al.   MOLECULAR THERAPY

StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins

(2018) Conor L. Jacobs et al.   NATURE METHODS

Chemogenetic control of gene expression and cell signaling with antiviral drugs

(2018) Elliot P. Tague et al.   NATURE METHODS

Chemically induced proximity in biology and medicine

(2018) Benjamin Z. Stanton et al.   SCIENCE

De novo design of a fluorescence-activating β-barrel

(2018) Jiayi Dou et al.   NATURE

Programmable protein circuits in living cells

(2018) Xiaojing J. Gao et al.   SCIENCE

Systematic testing of enzyme perturbation sensitivities via graded dCas9 modulation in Saccharomyces cerevisiae

(2017) Matthew Deaner et al.   METABOLIC ENGINEERING

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

(2017) Benjamin H Weinberg et al.   NATURE BIOTECHNOLOGY

Human antibody-based chemically induced dimerizers for cell therapeutic applications

(2017) Zachary B Hill et al.   Nature Chemical Biology

A platform for functional assessment of large variant libraries in mammalian cells

(2017) Kenneth A. Matreyek et al.   NUCLEIC ACIDS RESEARCH

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics

(2016) John C Rose et al.   Nature Chemical Biology

Complex transcriptional modulation with orthogonal and inducible dCas9 regulators

(2016) Yuchen Gao et al.   NATURE METHODS

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

(2016) Stephanie Berger et al.   eLife

Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

(2015) Jesse G. Zalatan et al.   CELL

Open source software for quantification of cell migration, protrusions, and fluorescence intensities

(2015) David J. Barry et al.   JOURNAL OF CELL BIOLOGY

Exploring the repeat protein universe through computational protein design

(2015) TJ Brunette et al.   NATURE

Tunable and reversible drug control of protein production via a self-excising degron

(2015) Hokyung K Chung et al.   Nature Chemical Biology

Highly efficient Cas9-mediated transcriptional programming

(2015) Alejandro Chavez et al.   NATURE METHODS

Control of repeat-protein curvature by computational protein design

(2015) Keunwan Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Galactose metabolic genes in yeast respond to a ratio of galactose and glucose

(2015) Renan Escalante-Chong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Control of repeat-protein curvature by computational protein design

(2015) Keunwan Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Precise assembly of complex beta sheet topologies from de novo designed building blocks

(2015) Indigo Chris King et al.   eLife

Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease

(2014) Djadé I. Soumana et al.   ACS Chemical Biology

Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters

(2014) Joanna L. MacKay et al.   Integrative Biology

Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening

(2013) Sanjib Dutta et al.   ACS Chemical Biology

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Computational Design of a Protein-Based Enzyme Inhibitor

(2013) Erik Procko et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthetic analog computation in living cells

(2013) Ramiz Daniel et al.   NATURE

High Affinity Peptide Inhibitors of the Hepatitis C Virus NS3-4A Protease Refractory to Common Resistant Mutants

(2012) Jonas Kügler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Redesign of the Binding Specificity of Anti-Apoptotic Bcl-xL

(2012) T. Scott Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid and orthogonal logic gating with a gibberellin-induced dimerization system

(2012) Takafumi Miyamoto et al.   Nature Chemical Biology

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

(2012) Keith P. Romano et al.   PLoS Pathogens

Enrich: software for analysis of protein function by enrichment and depletion of variants

(2011) Douglas M. Fowler et al.   BIOINFORMATICS

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

(2011) Sarel J. Fleishman et al.   PLoS One

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity

(2011) F.-S. Liang et al.   Science Signaling

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Improved Tet-responsive promoters with minimized background expression

(2010) Rainer Loew et al.   BMC BIOTECHNOLOGY

Noncooperative Interactions between Transcription Factors and Clustered DNA Binding Sites Enable Graded Transcriptional Responses to Environmental Inputs

(2010) Luca Giorgetti et al.   MOLECULAR CELL

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

(2010) K. P. Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA