Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

An exhaustive perspective on structural insights of SGLT2 inhibitors: A novel class of antidiabetic agent

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Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

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Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

(2019) Renhong Yan et al.   NATURE

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

(2019) Yongchan Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Empagliflozin: A Review in Type 2 Diabetes

(2018) James E. Frampton   DRUGS

New tools for automated high-resolution cryo-EM structure determination in RELION-3

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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Pharmacological aspects of the safety of gliflozins

(2017) Jean-Luc Faillie   PHARMACOLOGICAL RESEARCH

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2

(2016) Michael J. Coady et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors from Natural Products: Discovery of Next-Generation Antihyperglycemic Agents

(2016) Chang-Ik Choi   MOLECULES

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Covalently circularized nanodiscs for studying membrane proteins and viral entry

(2016) Mahmoud L Nasr et al.   NATURE METHODS

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

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How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

(2013) Aravind Penmatsa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Development of a novel non-radioactive cell-based method for the screening of SGLT1 and SGLT2 inhibitors using 1-NBDG

(2013) Hung-Chi Chang et al.   Molecular BioSystems

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Glucose transport by human renal Na+/d-glucose cotransporters SGLT1 and SGLT2

(2010) Charles S. Hummel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The mechanism of sodium and substrate release from the binding pocket of vSGLT

(2010) Akira Watanabe et al.   NATURE

Familial Renal Glucosuria and SGLT2: From a Mendelian Trait to a Therapeutic Target

(2009) R. Santer et al.   Clinical Journal of the American Society of Nephrology

Structure and function of Na+-symporters with inverted repeats

(2009) Jeff Abramson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters

(2009) Lucy R. Forrest et al.   PHYSIOLOGY

Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion

(2008) J. Calado et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

(2008) S. Faham et al.   SCIENCE