Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1

(2020) Heather S. Loring et al.   BIOCHEMISTRY

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

(2019) Deepak D. Bhandari et al.   Nature Communications

An Arabidopsis TIR-lectin two-domain protein confers defence properties against Tetranychus urticae

(2019) M. Estrella Santamaria et al.   PLANT PHYSIOLOGY

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Ligand-triggered allosteric ADP release primes a plant NLR complex

(2019) Jizong Wang et al.   SCIENCE

Structural Evidence for an Octameric Ring Arrangement of SARM1

(2019) Michael Sporny et al.   JOURNAL OF MOLECULAR BIOLOGY

A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

(2019) Dmitry Lapin et al.   PLANT CELL

Mutual interplay of Ca2+ and ROS signaling in plant immune response

(2019) Matthew J. Marcec et al.   PLANT SCIENCE

Help wanted: helper NLRs and plant immune responses

(2019) Lance M Jubic et al.   CURRENT OPINION IN PLANT BIOLOGY

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Transcriptomic Insights into Innate Immunity Responding to Red Rot Disease in Red Alga Pyropia yezoensis

(2019) Lei Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resolving the topological enigma in Ca2+-signaling by cyclic ADP-ribose and NAADP

(2019) Hon Cheung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

TaEDS1 genes positively regulate resistance to powdery mildew in wheat

(2018) Guiping Chen et al.   PLANT MOLECULAR BIOLOGY

Out of Water: The Origin and Early Diversification of Plant R-Genes

(2018) Yuxia Gao et al.   PLANT PHYSIOLOGY

Systematic discovery of antiphage defense systems in the microbial pangenome

(2018) Shany Doron et al.   SCIENCE

c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration

(2018) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling

(2018) Jeffrey D. Nanson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Ralstonia solanacearum effector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis

(2018) Yunhao Sun et al.   MOLECULAR PLANT PATHOLOGY

Differential regulation of TNL-mediated immune signaling by redundant helper CNLs

(2018) Zhongshou Wu et al.   NEW PHYTOLOGIST

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1

(2018) Baptiste Castel et al.   NEW PHYTOLOGIST

NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana

(2018) Tiancong Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Origin of Plant NBS-LRR Genes

(2018) Zhu-Qing Shao et al.   TRENDS IN PLANT SCIENCE

Exogenous Nicotinamide Adenine Dinucleotide Induces Resistance to Citrus Canker in Citrus

(2018) Fernando M. Alferez et al.   Frontiers in Plant Science

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

(2017) Dingzhong Tang et al.   PLANT CELL

The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events

(2017) Jonathan M. Urbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple functional self-association interfaces in plant TIR domains

(2017) Xiaoxiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death inArabidopsis

(2017) Marc T. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effector AvrRxo1 phosphorylates NAD in planta

(2017) Teja Shidore et al.   PLoS Pathogens

Protein-protein interactions in the RPS4/RRS1 immune receptor complex

(2017) Sung Un Huh et al.   PLoS Pathogens

3′-NADP and 3′-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1

(2016) Felix Schuebel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity

(2016) Haitao Cui et al.   NEW PHYTOLOGIST

NAD Acts as an Integral Regulator of Multiple Defense Layers

(2016) Pierre Pétriacq et al.   PLANT PHYSIOLOGY

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

(2016) Lachlan W. Casey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of the TIR Domain from the Grape NLR Protein RPV1

(2016) Simon J. Williams et al.   Frontiers in Plant Science

Calcium mobilizing second messengers derived from NAD

(2015) Andreas H. Guse   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

A Truncated NLR Protein, TIR-NBS2, Is Required for Activated Defense Responses in the exo70B1 Mutant

(2015) Ting Zhao et al.   PLoS Genetics

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

(2014) Thomas Ve et al.   APOPTOSIS

Tracing the origin and evolution of plant TIR-encoding genes

(2014) Xiaoqin Sun et al.   GENE

Physcomitrella patens Has Kinase-LRR R Gene Homologs and Interacting Proteins

(2014) Yusuke Tanigaki et al.   PLoS One

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity

(2013) Stephan Wagner et al.   Cell Host & Microbe

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Bacterial Interference with TLR4 Signaling byBrucellaToll/Interleukin-1 Receptor Domain-containing Protein TcpB

(2013) Mohammed Alaidarous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of TIR-NBS and TIR-X Proteins in Plant Basal Defense Responses

(2013) R. S. Nandety et al.   PLANT PHYSIOLOGY

Pivoting the Plant Immune System from Dissection to Deployment

(2013) J. L. Dangl et al.   SCIENCE

Recent Advances in Plant NLR Structure, Function, Localization, and Signaling

(2013) Dong Qi et al.   Frontiers in Immunology

How to build a pathogen detector: structural basis of NB-LRR function

(2012) Frank LW Takken et al.   CURRENT OPINION IN PLANT BIOLOGY

Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

(2012) Hon Cheung Lee   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the Human NAD(P)-Metabolizing Ectoenzyme CD38 Compromises Systemic Acquired Resistance in Arabidopsis

(2012) Xudong Zhang et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance

(2012) Shiwei Bai et al.   PLoS Pathogens

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

(2011) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death Mediated by the N-Terminal Domains of a Unique and Highly Conserved Class of NB-LRR Protein

(2011) Sarah M. Collier et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes

(2011) Jia-Xing Yue et al.   NEW PHYTOLOGIST

Genomic organization, induced expression and promoter activity of a resistance gene analog (PmTNL1) in western white pine (Pinus monticola)

(2011) Jun-Jun Liu et al.   PLANTA

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arabidopsis EDS1 Connects Pathogen Effector Recognition to Cell Compartment-Specific Immune Responses

(2011) K. Heidrich et al.   SCIENCE

TIR domain-containing adaptor SARM is a late addition to the ongoing microbe–host dialog

(2010) Qing Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Ca2+ conduction by plant cyclic nucleotide gated channels and associated signaling components in pathogen defense signal transduction cascades

(2010) Wei Ma et al.   NEW PHYTOLOGIST

Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans

(2009) Robert P. Shivers et al.   Cell Host & Microbe

Molecular Mimicry in Innate Immunity

(2009) Siew Leong Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TIR Domain of TIR-NB-LRR Resistance Proteins Is a Signaling Domain Involved in Cell Death Induction

(2009) Michal R. Swiderski et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Disruption of Poly(ADP-ribosyl)ation Mechanisms Alters Responses of Arabidopsis to Biotic Stress

(2009) L. Adams-Phillips et al.   PLANT PHYSIOLOGY

Microbial TIR domains: not necessarily agents of subversion?

(2009) Abigail M. Spear et al.   TRENDS IN MICROBIOLOGY

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens

(2008) Jens Staal et al.   PLANT JOURNAL