Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants

Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms

(2020) Hailong Guo et al.   Cell Host & Microbe

Bacterial Effectors Induce Oligomerization of Immune Receptor ZAR1 In Vivo

(2020) Meijuan Hu et al.   Molecular Plant

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Ligand-triggered allosteric ADP release primes a plant NLR complex

(2019) Jizong Wang et al.   SCIENCE

An EDS1-SAG101 Complex is Essential for TNL-mediated Immunity in Nicotiana benthamiana

(2019) Johannes Gantner et al.   PLANT CELL

A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

(2019) Dmitry Lapin et al.   PLANT CELL

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors

(2018) Yan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly

(2018) Mariusz Matyszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1

(2018) Baptiste Castel et al.   NEW PHYTOLOGIST

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

(2018) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana

(2018) Tiancong Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Roq1 mediates recognition of the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1

(2017) Alex Schultink et al.   PLANT JOURNAL

Multiple functional self-association interfaces in plant TIR domains

(2017) Xiaoxiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death inArabidopsis

(2017) Marc T. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

(2017) Jeannette L. Tenthorey et al.   SCIENCE

Pathogen perception by NLRs in plants and animals: Parallel worlds

(2016) Zane Duxbury et al.   BIOESSAYS

Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model

(2016) Maud Bernoux et al.   PLANT CELL

Cytosolic activation of cell death and stem rust resistance by cereal MLA-family CC–NLR proteins

(2016) Stella Cesari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors

(2015) Panagiotis F. Sarris et al.   CELL

The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants

(2015) Guoxun Wang et al.   Cell Host & Microbe

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

(2015) Christoph A. Diebolder et al.   STRUCTURE

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana

(2014) Kee Hoon Sohn et al.   PLoS Genetics

Consequences of flagellin export through the type III secretion system ofPseudomonas syringaereveal a major difference in the innate immune systems of mammals and the model plantNicotiana benthamiana

(2012) Hai-Lei Wei et al.   CELLULAR MICROBIOLOGY

Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death

(2011) Takaki Maekawa et al.   Cell Host & Microbe

Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology

(2011) Chiung-Ya Chen et al.   JOURNAL OF CELL BIOLOGY

N-Terminal Motifs in Some Plant Disease Resistance Proteins Function in Membrane Attachment and Contribute to Disease Resistance

(2011) Daigo Takemoto et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

A Modular Cloning System for Standardized Assembly of Multigene Constructs

(2011) Ernst Weber et al.   PLoS One

Balanced Nuclear and Cytoplasmic Activities of EDS1 Are Required for a Complete Plant Innate Immune Response

(2010) Ana V. García et al.   PLoS Pathogens

The TIR Domain of TIR-NB-LRR Resistance Proteins Is a Signaling Domain Involved in Cell Death Induction

(2009) Michal R. Swiderski et al.   MOLECULAR PLANT-MICROBE INTERACTIONS