The N-terminal Region of the DNA-dependent Protein Kinase Catalytic Subunit Is Required for Its DNA Double-stranded Break-mediated Activation

Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome

(2012) Melissa M. Dix et al.   CELL

Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination

(2012) Zhengping Shao et al.   DNA REPAIR

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku

(2011) K. Meek et al.   NUCLEIC ACIDS RESEARCH

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes

(2008) Richard Hill et al.   DNA REPAIR

DNA-PK suppresses a p53-independent apoptotic response to DNA damage

(2008) Kay E Gurley et al.   EMBO REPORTS

Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding

(2008) Dewight R. Williams et al.   STRUCTURE