Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation

LAG3’s Enigmatic Mechanism of Action

(2021) Colin G. Graydon et al.   Frontiers in Immunology

Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial

(2021) Maria Antonietta Nettis et al.   NEUROPSYCHOPHARMACOLOGY

Electric Neurostimulation Regulates Microglial Activation via Retinoic Acid Receptor α Signaling

(2021) Smadar Goldfarb et al.   BRAIN BEHAVIOR AND IMMUNITY

Translocator Protein Distribution Volume Predicts Reduction of Symptoms During Open-Label Trial of Celecoxib in Major Depressive Disorder

(2020) Sophia Attwells et al.   BIOLOGICAL PSYCHIATRY

Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress

(2020) Zixuan Cai et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Electroconvulsive stimulation attenuates chronic neuroinflammation

(2020) Smadar Goldfarb et al.   JCI Insight

Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis

(2020) Ben Bassett et al.   BRAIN BEHAVIOR AND IMMUNITY

Do different types of stress differentially alter behavioural and neurobiological outcomes associated with depression in rodent models? A systematic review

(2020) Andrea Du Preez et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The antidepressant impact of minocycline in rodents: A systematic review and meta-analysis

(2019) Daniel J. Reis et al.   Scientific Reports

Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

(2019) Anthony J. Martorell et al.   CELL

Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium

(2019) Gara Arteaga-Henríquez et al.   Frontiers in Psychiatry

Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation

(2019) Yue Han et al.   PSYCHONEUROENDOCRINOLOGY

Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation

(2019) Francesca Grassivaro et al.   JOURNAL OF NEUROSCIENCE

Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study

(2018) Sophie E. Holmes et al.   BIOLOGICAL PSYCHIATRY

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Different effects of immune stimulation on chronic unpredictable mild stress-induced anxiety- and depression-like behaviors depending on timing of stimulation

(2018) Jiangyan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials

(2018) Joshua D. Rosenblat et al.   JOURNAL OF AFFECTIVE DISORDERS

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

(2018) Ya-Lin Wang et al.   Journal of Neuroinflammation

Microglial immune checkpoint mechanisms

(2018) Aleksandra Deczkowska et al.   NATURE NEUROSCIENCE

Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation

(2018) Yu Gong et al.   NEUROPHARMACOLOGY

Blood-brain barrier regulation in psychiatric disorders

(2018) John Kealy et al.   NEUROSCIENCE LETTERS

Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder

(2018) Gouri J. Mahajan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial

(2018) Jonathan B. Savitz et al.   Translational Psychiatry

Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder

(2018) Hua Li et al.   JOURNAL OF AFFECTIVE DISORDERS

Unique role for dentate gyrus microglia in neuroblast survival and in VEGF-induced activation

(2018) Tirzah Kreisel et al.   GLIA

Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal

(2017) T. Jordan Walter et al.   Journal of Neuroinflammation

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses

(2017) Lijuan Tong et al.   NEUROCHEMICAL RESEARCH

Microglia: An Interface between the Loss of Neuroplasticity and Depression

(2017) Gaurav Singhal et al.   Frontiers in Cellular Neuroscience

The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb

(2017) Ronen Reshef et al.   eLife

Mouse repeated electroconvulsive seizure (ECS) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT) side-effects in the treatment of depression

(2017) Erin M. van Buel et al.   PLoS One

Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment

(2016) Silvia Alboni et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

(2016) Sabine Hellwig et al.   BRAIN BEHAVIOR AND IMMUNITY

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

(2016) Giampaolo Milior et al.   BRAIN BEHAVIOR AND IMMUNITY

Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

(2016) Alexandra K. Brooks et al.   Journal of Neuroinflammation

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals

(2016) Sarah M. Clark et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

(2016) S P Pantazatos et al.   MOLECULAR PSYCHIATRY

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

(2016) Yuji Ogura et al.   Nature Chemical Biology

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

The current state of the neurogenic theory of depression and anxiety

(2015) Bradley R Miller et al.   CURRENT OPINION IN NEUROBIOLOGY

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

(2015) M H Rapaport et al.   MOLECULAR PSYCHIATRY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis

(2014) Ronen Reshef et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

The effect of dopamine on adult hippocampal neurogenesis

(2014) Naoki Takamura et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Never-resting microglia: physiological roles in the healthy brain and pathological implications

(2014) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations

(2014) Peter Rotheneichner et al.   NEURAL PLASTICITY

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

(2014) Amanda Sierra et al.   NEURAL PLASTICITY

Lower CSF interleukin-6 predicts future depression in a population-based sample of older women followed for 17 years

(2013) Silke Kern et al.   BRAIN BEHAVIOR AND IMMUNITY

The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study

(2013) Jonas Hannestad et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

(2013) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

(2012) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of immune genes in the association between depression and inflammation: A review of recent clinical studies

(2012) Chiara Bufalino et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline

(2012) M. Hinwood et al.   CEREBRAL CORTEX

Targeting IL-1 in depression

(2012) Michael Maes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Phenelzine (Monoamine Oxidase Inhibitor) Increases Production of Nitric Oxide and Proinflammatory Cytokines via the NF-κB Pathway in Lipopolysaccharide-Activated Microglia Cells

(2012) Hwan-Suck Chung et al.   NEUROCHEMICAL RESEARCH

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells

(2011) Neta Rimmerman et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Antidepressants recruit new neurons to improve stress response regulation

(2011) A Surget et al.   MOLECULAR PSYCHIATRY

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans

(2011) J. L. Warner-Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-  Production in Vivo

(2011) J. K. Atwal et al.   Science Translational Medicine

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium

(2010) Hideki Horikawa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis

(2009) Anja Haslinger et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glial cell activation in response to electroconvulsive seizures

(2009) Linda Jansson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Dopamine Controls Persistence of Long-Term Memory Storage

(2009) J. I. Rossato et al.   SCIENCE

Seizure (Ictal)—EEG Characteristics in Subgroups of Depressive Disorder in Patients Receiving Electroconvulsive Therapy (ECT)—A Preliminary Study and Multivariate Approach

(2009) Björn Wahlund et al.   Computational Intelligence and Neuroscience

Reduction of Iba1-expressing microglial process density in the hippocampus following electroconvulsive shock

(2008) Shozo Jinno et al.   EXPERIMENTAL NEUROLOGY

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Brain inflammation and adult neurogenesis: The dual role of microglia

(2008) C.T. Ekdahl et al.   NEUROSCIENCE

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH