Sugar-Phosphate Toxicities

Infection-based chemical screens uncover host–pathogen interactions

(2020) Corrella S Detweiler   CURRENT OPINION IN MICROBIOLOGY

Translation inhibition from a distance: The small RNA SgrS silences a ribosomal protein S1‐dependent enhancer

(2020) Muhammad S. Azam et al.   MOLECULAR MICROBIOLOGY

Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice

(2020) Toni A. Nagy et al.   ACS Infectious Diseases

Phosphosugar stress in Bacillus subtilis: Intracellular accumulation of mannose 6-phosphate derepresed the glcR-phoC operon from repression by GlcR

(2019) Kambiz Morabbi Heravi et al.   JOURNAL OF BACTERIOLOGY

Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus

(2019) Thanh Nguyen et al.   mBio

Integrated use of biochemical, native mass spectrometry, computational and genome-editing methods to elucidate the mechanism of a deglycase

(2019) Anindita Sengupta et al.   JOURNAL OF MOLECULAR BIOLOGY

Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease

(2019) Amée M. Buziau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pathophysiology and targets for treatment in hereditary galactosemia: A systematic review of animal and cellular models

(2019) Minela Haskovic et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

(2018) Cholsoon Jang et al.   Cell Metabolism

Is water a suitable medium for the Amadori rearrangement?

(2018) Suresh Pal et al.   FOOD CHEMISTRY

Salmonella -Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut

(2018) Jikang Wu et al.   INFECTION AND IMMUNITY

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice

(2018) Miguel A. Lanaspa et al.   JOURNAL OF CLINICAL INVESTIGATION

Hereditary galactosemia

(2018) Didem Demirbas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast

(2018) Patrick A. Gibney et al.   MOLECULAR BIOLOGY OF THE CELL

In silico Predicted Glucose-1-phosphate Uridylyltransferase (GalU) Inhibitors Block a Key Pathway Required for Listeria Virulence

(2018) Melaine A. Kuenemann et al.   Molecular Informatics

Machine learning identifies signatures of host adaptation in the bacterial pathogen Salmonella enterica

(2018) Nicole E. Wheeler et al.   PLoS Genetics

A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load

(2018) Abigail L. Reens et al.   PLoS Pathogens

Few Differences in Metabolic Network Use Found Between Salmonella enterica Colonization of Plants and Typhoidal Mice

(2018) Grace Kwan et al.   Frontiers in Microbiology

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

Defining the Metabolic Pathways and Host-Derived Carbon Substrates Required for Francisella tularensis Intracellular Growth

(2018) Lauren C. Radlinski et al.   mBio

Measurement of Fructose–Asparagine Concentrations in Human and Animal Foods

(2017) Jikang Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Small Protein SgrT Controls Transport Activity of the Glucose-Specific Phosphotransferase System

(2017) Chelsea R. Lloyd et al.   JOURNAL OF BACTERIOLOGY

Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization

(2017) Anice Sabag-Daigle et al.   JOURNAL OF BACTERIOLOGY

Screening assay for inhibitors of a recombinant Streptococcus pneumoniae UDP-glucose pyrophosphorylase

(2017) Agustín Zavala et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Impaired fertility and motor function in a zebrafish model for classic galactosemia

(2017) Jo M. Vanoevelen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Liver involvement in congenital disorders of glycosylation (CDG). A systematic review of the literature

(2017) D. Marques-da-Silva et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development

(2017) Arsa Thammahong et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The MetaCyc database of metabolic pathways and enzymes

(2017) Ron Caspi et al.   NUCLEIC ACIDS RESEARCH

Reversible synthesis of colanic acid and O-antigen polysaccharides in Salmonella Typhimurium enhances induction of cross-immune responses and provides protection against heterologous Salmonella challenge

(2017) Pei Li et al.   VACCINE

Capsule Production and Glucose Metabolism Dictate Fitness during Serratia marcescens Bacteremia

(2017) Mark T. Anderson et al.   mBio

Identification of a New Phosphatase Enzyme Potentially Involved in the Sugar Phosphate Stress Response in Pseudomonas fluorescens

(2016) Susan Maleki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis of 6-phosphofructose aspartic acid and some related Amadori compounds

(2016) Alexandar L. Hansen et al.   CARBOHYDRATE RESEARCH

Use of Attenuated but Metabolically Competent Salmonella as a Probiotic To Prevent or Treat Salmonella Infection

(2016) Anice Sabag-Daigle et al.   INFECTION AND IMMUNITY

A family of metal-dependent phosphatases implicated in metabolite damage-control

(2016) Lili Huang et al.   Nature Chemical Biology

Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli

(2016) Daniel C Sévin et al.   NATURE METHODS

A Tale of Two Sugars: Trehalose 6-Phosphate and Sucrose

(2016) Carlos M. Figueroa et al.   PLANT PHYSIOLOGY

Mannitol in Plants, Fungi, and Plant–Fungal Interactions

(2016) Takshay K. Patel et al.   TRENDS IN PLANT SCIENCE

Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis

(2016) Matt S. Conover et al.   mBio

Metabolism of Toxic Sugars by Strains of the Bee Gut Symbiont Gilliamella apicola

(2016) Hao Zheng et al.   mBio

A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant

(2016) Anice Sabag-Daigle et al.   Scientific Reports

Trehalose pathway as an antifungal target

(2016) John R. Perfect et al.   Virulence

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

(2016) Hendrik Koliwer-Brandl et al.   PLoS Pathogens

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

(2016) Jan Korte et al.   PLoS Pathogens

Mutational Analyses of Glucose Dehydrogenase and Glucose-6-Phosphate Dehydrogenase Genes in Pseudomonas fluorescens Reveal Their Effects on Growth and Alginate Production

(2015) Susan Maleki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structure and Function of Prokaryotic UDP-Glucose Pyrophosphorylase, A Drug Target Candidate

(2015) M. Berbis et al.   CURRENT MEDICINAL CHEMISTRY

Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress

(2015) Maksym Bobrovskyy et al.   MOLECULAR MICROBIOLOGY

Reconstructing pathogen evolution from the ruins

(2015) Sean-Paul Nuccio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential Use of Central Metabolism In Vivo Reveals a Nutritional Basis for Polymicrobial Infection

(2015) Christopher J. Alteri et al.   PLoS Pathogens

Mannitol metabolism during pathogenic fungal–host interactions under stressed conditions

(2015) Mukesh Meena et al.   Frontiers in Microbiology

In Vitro Assembly of the Outer Core of the Lipopolysaccharide from Escherichia coli K-12 and Salmonella typhimurium

(2014) Jinghua Qian et al.   BIOCHEMISTRY

Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress

(2014) Miriam Sand et al.   ENVIRONMENTAL MICROBIOLOGY

Subfertility and growth restriction in a new galactose-1 phosphate uridylyltransferase (GALT) - deficient mouse model

(2014) Manshu Tang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Developmental Defects in a Caenorhabditis elegans Model for Type III Galactosemia

(2014) Ana M. Brokate-Llanos et al.   GENETICS

Synthesis of a Poly-hydroxypyrolidine-Based inhibitor of Mycobacterium tuberculosis GlgE

(2014) Sri Kumar Veleti et al.   JOURNAL OF ORGANIC CHEMISTRY

The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

(2014) Josef Deutscher et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Patterns of genome evolution that have accompanied host adaptation inSalmonella

(2014) Gemma C. Langridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Changes Signal Genetic Regulatory Mechanisms for Robust Cell Behavior

(2014) S. J. Lee et al.   mBio

Fructose-Asparagine Is a Primary Nutrient during Growth of Salmonella in the Inflamed Intestine

(2014) Mohamed M. Ali et al.   PLoS Pathogens

The small RNA SgrS: roles in metabolism and pathogenesis of enteric bacteria

(2014) Maksym Bobrovskyy et al.   Frontiers in Cellular and Infection Microbiology

Small RNA-Mediated Activation of Sugar Phosphatase mRNA Regulates Glucose Homeostasis

(2013) Kai Papenfort et al.   CELL

Flux through Trehalose Synthase Flows from Trehalose to the Alpha Anomer of Maltose in Mycobacteria

(2013) Farzana Miah et al.   CHEMISTRY & BIOLOGY

Trehalose 6-phosphate phosphatase is required for development, virulence and mycotoxin biosynthesis apart from trehalose biosynthesis in Fusarium graminearum

(2013) Xiu-Shi Song et al.   FUNGAL GENETICS AND BIOLOGY

Depletion of Glycolytic Intermediates Plays a Key Role in Glucose-Phosphate Stress in Escherichia coli

(2013) G. R. Richards et al.   JOURNAL OF BACTERIOLOGY

Physiological Consequences of Multiple-Target Regulation by the Small RNA SgrS in Escherichia coli

(2013) Y. Sun et al.   JOURNAL OF BACTERIOLOGY

Mannitol Utilisation is Required for Protection of Staphylococcus aureus from Human Skin Antimicrobial Fatty Acids

(2013) John G. Kenny et al.   PLoS One

Inactivation of Metabolic Genes Causes Short- and Long-Range dys-Regulation in Escherichia coli Metabolic Network

(2013) Dinesh Kumar Barupal et al.   PLoS One

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence

(2013) Benjamin Steeb et al.   PLoS Pathogens

Induction of the Pho Regulon Suppresses the Growth Defect of an Escherichia coli sgrS Mutant, Connecting Phosphate Metabolism to the Glucose-Phosphate Stress Response

(2012) G. R. Richards et al.   JOURNAL OF BACTERIOLOGY

The Rhizome of the Multidrug-Resistant Enterobacter aerogenes Genome Reveals How New “Killer Bugs” Are Created because of a Sympatric Lifestyle

(2012) Seydina M. Diene et al.   MOLECULAR BIOLOGY AND EVOLUTION

A glycine betaine importer limitsSalmonellastress resistance and tissue colonization by reducing trehalose production

(2012) M. Carolina Pilonieta et al.   MOLECULAR MICROBIOLOGY

Identification and Analysis of the Putative Pentose Sugar Efflux Transporters in Escherichia coli

(2012) Khushnuma Koita et al.   PLoS One

Transcriptome Analysis of the Asian Honey Bee Apis cerana cerana

(2012) Zi Long Wang et al.   PLoS One

The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair

(2012) K. Papenfort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella enterica: a surprisingly well-adapted intracellular lifestyle

(2012) Thomas Dandekar et al.   Frontiers in Microbiology

Characterization and regulation of a bacterial sugar phosphatase of the haloalkanoate dehalogenase superfamily, AraL, from Bacillus subtilis

(2011) Lia M. Godinho et al.   FEBS Journal

Mannose-6-phosphate pathway: A review on its role in lysosomal function and dysfunction

(2011) Maria Francisca Coutinho et al.   MOLECULAR GENETICS AND METABOLISM

The small RNA SgrS controls sugar–phosphate accumulation by regulating multiple PTS genes

(2011) Jennifer B. Rice et al.   NUCLEIC ACIDS RESEARCH

Characterization of UDP-Glucose Dehydrogenase and UDP-Glucose Pyrophosphorylase Mutants of Proteus mirabilis: Defectiveness in Polymyxin B Resistance, Swarming, and Virulence

(2010) S. S. Jiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Drosophila melanogaster model of classic galactosemia

(2010) R. F. Kushner et al.   Disease Models & Mechanisms

CsrA and Cra Influence Shigella flexneri Pathogenesis

(2010) A. L. Gore et al.   INFECTION AND IMMUNITY

Regulation and Function of Escherichia coli Sugar Efflux Transporter A (SetA) during Glucose-Phosphate Stress

(2010) Y. Sun et al.   JOURNAL OF BACTERIOLOGY

Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus

(2010) Srisombat Puttikamonkul et al.   MOLECULAR MICROBIOLOGY

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

(2010) Rainer Kalscheuer et al.   Nature Chemical Biology

Carbon Metabolism of Enterobacterial Human Pathogens Growing in Epithelial Colorectal Adenocarcinoma (Caco-2) Cells

(2010) Andreas Götz et al.   PLoS One

Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis

(2010) R. Kalscheuer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

The Metabolic Enzyme ManA Reveals a Link between Cell Wall Integrity and Chromosome Morphology

(2010) Maya Elbaz et al.   PLoS Genetics

Wall Teichoic Acid Function, Biosynthesis, and Inhibition

(2009) Jonathan G. Swoboda et al.   CHEMBIOCHEM

Genetic stability of vaccine strain Salmonella Typhi Ty21a over 25 years

(2009) Dennis J. Kopecko et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans

(2009) María Martínez-Esparza et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Galactose toxicity in animals

(2009) Kent Lai et al.   IUBMB LIFE

Redundancy in the requirement for the glycolytic enzymes phosphofructokinase (Pfk) 1 and 2 in the in vivo fitness of Salmonella enterica serovar Typhimurium

(2009) G.K. Paterson et al.   MICROBIAL PATHOGENESIS

Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and morphogenesis

(2009) W. Fang et al.   MICROBIOLOGY-SGM

Homologs of the small RNA SgrS are broadly distributed in enteric bacteria but have diverged in size and sequence

(2009) Richard S. P. Horler et al.   NUCLEIC ACIDS RESEARCH

Cellular stress created by intermediary metabolite imbalances

(2009) S. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Inactivation of the Candida albicans GPR1 and TPS2 Genes Results in Avirulence in a Mouse Model for Systemic Infection

(2008) M. M. Maidan et al.   INFECTION AND IMMUNITY

Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA

(2008) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA