Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli

Avoiding Misannotation of In-Source Fragmentation Products as Cellular Metabolites in Liquid Chromatography–Mass Spectrometry-Based Metabolomics

(2015) Yi-Fan Xu et al.   ANALYTICAL CHEMISTRY

High-throughput discovery metabolomics

(2015) Tobias Fuhrer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Illuminating the dark matter in metabolomics: Fig. 1.

(2015) Ricardo R. da Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling the orphan enzymes

(2014) Maria Sorokina et al.   Biology Direct

Finding Sequences for over 270 Orphan Enzymes

(2014) Alexander G. Shearer et al.   PLoS One

Network-level architecture and the evolutionary potential of underground metabolism

(2014) R. A. Notebaart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MyCompoundID: Using an Evidence-Based Metabolome Library for Metabolite Identification

(2013) Liang Li et al.   ANALYTICAL CHEMISTRY

Discovery of new enzymes and metabolic pathways by using structure and genome context

(2013) Suwen Zhao et al.   NATURE

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Metabolite damage and its repair or pre-emption

(2013) Carole L Linster et al.   Nature Chemical Biology

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

(2012) Warwick B. Dunn et al.   Metabolomics

Global probabilistic annotation of metabolic networks enables enzyme discovery

(2012) Germán Plata et al.   Nature Chemical Biology

Network Context and Selection in the Evolution to Enzyme Specificity

(2012) H. Nam et al.   SCIENCE

High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry

(2011) Tobias Fuhrer et al.   ANALYTICAL CHEMISTRY

Mining high-throughput experimental data to link gene and function

(2011) Crysten E. Blaby-Haas et al.   TRENDS IN BIOTECHNOLOGY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

SIMCOMP/SUBCOMP: chemical structure search servers for network analyses

(2010) M. Hattori et al.   NUCLEIC ACIDS RESEARCH

‘Unknown’ proteins and ‘orphan’ enzymes: the missing half of the engineering parts list – and how to find it

(2009) Andrew D. Hanson et al.   BIOCHEMICAL JOURNAL

Metabolite Profiling Reveals YihU as a Novel Hydroxybutyrate Dehydrogenase for Alternative Succinic Semialdehyde Metabolism inEscherichia coli

(2009) Natsumi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Update on the Keio collection of Escherichia coli single-gene deletion mutants

(2009) Natsuko Yamamoto et al.   Molecular Systems Biology

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Exploration of Uncharted Regions of the Protein Universe

(2009) Lukasz Jaroszewski et al.   PLOS BIOLOGY

Reconstruction of biochemical networks in microorganisms

(2008) Adam M. Feist et al.   NATURE REVIEWS MICROBIOLOGY