Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease

Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats

(2019) Laura G. Sánchez-Lozada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patients with aldolase B deficiency are characterized by an increased intrahepatic triglyceride content

(2019) Nynke Simons et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Non-alcoholic fatty liver in hereditary fructose intolerance

(2019) Luis Aldámiz-Echevarría et al.   CLINICAL NUTRITION

Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver

(2018) Eunsook S. Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ketohexokinase Knockout Mice, a Model for Essential Fructosuria, Exhibit Altered Fructose Metabolism and are Protected from Diet-induced Metabolic Defects

(2018) Corin Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

(2018) Alessandro Mantovani et al.   DIABETES CARE

Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice

(2018) Miguel A. Lanaspa et al.   JOURNAL OF CLINICAL INVESTIGATION

Fructose metabolism and metabolic disease

(2018) Sarah A. Hannou et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute liver failure in neonates with undiagnosed hereditary fructose intolerance due to exposure from widely available infant formulas

(2018) Hong Li et al.   MOLECULAR GENETICS AND METABOLISM

Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis

(2018) Pomme I. H. G. Simons et al.   PLoS One

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2017) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

(2017) Kim Huard et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation

(2017) Kaitlin Mock et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies

(2016) Nynke Simons et al.   DIABETES CARE

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

(2016) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase

(2016) MyPhuong T. Le et al.   PLoS One

Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in theGCKRGene

(2015) Nicola Santoro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans

(2015) Sarah A. Oppelt et al.   MOLECULAR GENETICS AND METABOLISM

Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?

(2015) Martijn C.G.J. Brouwers et al.   TRENDS IN MOLECULAR MEDICINE

Differences and similarities in hepatic lipogenesis, gluconeogenesis and oxidative imbalance in mice fed diets rich in fructose or sucrose

(2015) Alini Schultz et al.   Food & Function

Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials

(2014) S Chiu et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Hyperosmolarity drives hypertension and CKD—water and salt revisited

(2014) Richard J. Johnson et al.   Nature Reviews Nephrology

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

(2013) Tobias Beck et al.   BIOCHEMISTRY

Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men

(2013) Y. Mahendran et al.   DIABETES

High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase

(2013) Takuji Ishimoto et al.   HEPATOLOGY

Fructokinase activity mediates dehydration-induced renal injury

(2013) Carlos A. Roncal Jimenez et al.   KIDNEY INTERNATIONAL

Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase

(2013) J. M. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

(2013) Miguel A. Lanaspa et al.   Nature Communications

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

(2012) Daniel W. Foster   JOURNAL OF CLINICAL INVESTIGATION

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice

(2012) T. Ishimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability

(2011) P. Swärd et al.   Acta Physiologica

ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity

(2011) Carmen Hurtado del Pozo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

(2011) Nicola Santoro et al.   HEPATOLOGY

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol

(2010) Robert H. Lustig   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Association of rs780094 in GCKR with Metabolic Traits and Incident Diabetes and Cardiovascular Disease: The ARIC Study

(2010) Mark Bi et al.   PLoS One

Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance

(2009) Kimber L Stanhope et al.   CURRENT OPINION IN LIPIDOLOGY

Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms

(2009) P. van der Harst et al.   HUMAN MOLECULAR GENETICS

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Fructose: should we worry?

(2009) G A Bray   INTERNATIONAL JOURNAL OF OBESITY

Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response

(2009) S E Perez-Pozo et al.   INTERNATIONAL JOURNAL OF OBESITY

Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme

(2009) Christine P. Diggle et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Increased prevalence of mutant null alleles that cause hereditary fructose intolerance in the American population

(2009) Erin M. Coffee et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Secondary disorders of glycosylation in inborn errors of fructose metabolism

(2009) E. Quintana et al.   JOURNAL OF INHERITED METABOLIC DISEASE

National Estimates of Dietary Fructose Intake Increased from 1977 to 2004 in the United States

(2009) Bernadette P. Marriott et al.   JOURNAL OF NUTRITION

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Glucokinase and molecular aspects of liver glycogen metabolism

(2008) Loranne Agius   BIOCHEMICAL JOURNAL

The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

(2008) M. Vaxillaire et al.   DIABETES

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

(2008) M. Orho-Melander et al.   DIABETES

Proteomic analysis of fructose-induced fatty liver in hamsters

(2008) Lihe Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL