Alzheimer's disease associated with Down syndrome: a genetic form of dementia

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Systematic review of coexistent epileptic seizures and Alzheimer's disease: Incidence and prevalence

(2021) Ying Xu et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

(2021) Jessica A. Beresford-Webb et al.   BJPsych Open

Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome

(2021) Victor Montal et al.   ANNALS OF NEUROLOGY

Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias

(2021) Daniel Alcolea et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study

(2021) Anne M Fagan et al.   LANCET NEUROLOGY

Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study

(2021) Maria Carmona-Iragui et al.   LANCET NEUROLOGY

Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome

(2021) Alberto Lleó et al.   Nature Communications

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

(2021) Alexandre Bejanin et al.   JAMA Neurology

Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity

(2021) Miren Altuna et al.   Journal of Clinical Medicine

Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2020) Juan Fortea et al.   LANCET

Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study

(2020) Yakeel T Quiroz et al.   LANCET NEUROLOGY

Cause of death in adults with Down syndrome in the US

(2020) Scott D. Landes et al.   Disability and Health Journal

Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

(2020) Alexandra Botté et al.   Acta Neuropathologica Communications

Prognostic Accuracy of Fetal MRI in Predicting Postnatal Neurodevelopmental Outcome

(2020) M. Wilson et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Alzheimer‐Related Cerebrovascular Disease in Down Syndrome

(2020) Patrick J. Lao et al.   ANNALS OF NEUROLOGY

Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

(2020) Olivia Belbin et al.   Molecular Neurodegeneration

Association of sleep with cognition and beta amyloid accumulation in adults with Down syndrome

(2020) Karly A. Cody et al.   NEUROBIOLOGY OF AGING

Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome

(2020) Rosalyn Hithersay et al.   Alzheimers & Dementia

Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study

(2020) Rowan Pentz et al.   Alzheimers & Dementia

Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

(2020) Lisi Flores-Aguilar et al.   BRAIN

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome

(2020) Melissa E. Petersen et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood-based molecular biomarkers for Alzheimer’s disease

(2019) Henrik Zetterberg et al.   Molecular Brain

Dementia in Down syndrome: unique insights for Alzheimer disease research

(2019) Ira T. Lott et al.   Nature Reviews Neurology

Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

(2019) Sylvia E. Perez et al.   ACTA NEUROPATHOLOGICA

Down syndrome, Alzheimer disease, and cerebral amyloid angiopathy: The complex triangle of brain amyloidosis

(2019) María Carmona‐Iragui et al.   Developmental Neurobiology

Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease

(2018) David M. A. Mann et al.   ACTA NEUROPATHOLOGICA

Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition

(2018) Ann D. Cohen et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

(2018) Frances K Wiseman et al.   BRAIN

The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome

(2018) Alain D. Dekker et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease

(2018) Eric McDade et al.   JAMA Neurology

Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome

(2018) Natalie Neale et al.   NeuroImage-Clinical

Aging related cognitive changes associated with Alzheimer's disease in Down syndrome

(2018) Nicholas C. Firth et al.   Annals of Clinical and Translational Neurology

Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2018) Juan Fortea et al.   LANCET NEUROLOGY

Comparison of longitudinal Aβ in non-demented elderly and Down syndrome

(2018) Dana L. Tudorascu et al.   NEUROBIOLOGY OF AGING

Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome

(2018) Carla M. Startin et al.   Alzheimers & Dementia

Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings

(2018) Sandra Giménez et al.   Journal of Clinical Sleep Medicine

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

(2018) Rosalyn Hithersay et al.   JAMA Neurology

The clinical and neurobehavioral course of Down syndrome and dementia with or without new-onset epilepsy

(2017) Taha Gholipour et al.   EPILEPSY & BEHAVIOR

Predictors of Age of Diagnosis and Survival of Alzheimer’s Disease in Down Syndrome

(2017) Amanda Sinai et al.   JOURNAL OF ALZHEIMERS DISEASE

PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

(2017) Michael S. Rafii et al.   JOURNAL OF ALZHEIMERS DISEASE

Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP

(2017) Eric Doran et al.   JOURNAL OF ALZHEIMERS DISEASE

The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis

(2017) Tiina Annus et al.   NEUROBIOLOGY OF AGING

Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome

(2017) Sigan L. Hartley et al.   NEUROBIOLOGY OF AGING

The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies

(2017) Bianca Alexandra Lautarescu et al.   NEUROPSYCHOLOGY REVIEW

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

(2017) Kelly D. Sullivan et al.   Scientific Reports

Cerebrovascular pathology in Down syndrome and Alzheimer disease

(2017) Elizabeth Head et al.   Acta Neuropathologica Communications

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

(2016) Seonjoo Lee et al.   ANNALS OF NEUROLOGY

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Dementia in Down's syndrome

(2016) Clive Ballard et al.   LANCET NEUROLOGY

Assessing Specific Cognitive Deficits Associated with Dementia in Older Adults with Down Syndrome: Use and Validity of the Arizona Cognitive Test Battery (ACTB)

(2016) Amanda Sinai et al.   PLoS One

Epilepsy in children with Down syndrome: not so benign as generally accepted

(2015) Marisse Meeus et al.   ACTA NEUROLOGICA BELGICA

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

(2015) Donna M. Wilcock et al.   NEUROBIOLOGY OF AGING

Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred

(2015) Adam S. Fleisher et al.   JAMA Neurology

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

(2014) Alberto Lleó et al.   Nature Reviews Neurology

Changes in mortality and causes of death in the Swedish Down syndrome population

(2013) Annika Englund et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

(2013) Krista L Moulder et al.   Alzheimers Research & Therapy

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial

(2012) Marisa Hanney et al.   LANCET

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype

(2011) Yvonne S. Davidson et al.   ACTA NEUROPATHOLOGICA

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

(2011) Giovanna Cenini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Clinical and EEG Features of Seizures in Adults With Down Syndrome

(2011) Stela Lefter et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study

(2011) Natalia Acosta-Baena et al.   LANCET NEUROLOGY

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

Variations in the neuropathology of familial Alzheimer’s disease

(2009) Claire Shepherd et al.   ACTA NEUROPATHOLOGICA

High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types

(2009) Victor L. Villemagne et al.   ARCHIVES OF NEUROLOGY

Transactive Response DNA-Binding Protein 43 Burden in Familial Alzheimer Disease and Down Syndrome

(2009) Carol F. Lippa et al.   ARCHIVES OF NEUROLOGY

Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down Syndrome

(2008) V. P. Prasher et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Oxidative stress and cognitive ability in adults with Down syndrome

(2008) Andre Strydom et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY