Journal
NEUROBIOLOGY OF AGING
Volume 73, Issue -, Pages 171-176Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.09.030
Keywords
Down syndrome; Amyloid; Alzheimer's disease
Categories
Funding
- National Institutes of Health [P50 AG005133, RF1 AG025516, R01AG031110, U01AG051406]
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Down syndrome (DS) predisposes individuals to early Alzheimer's disease (AD). Using Pittsburgh Compound B ([C-11]PiB), a pattern of striatal amyloid beta (A beta) that is elevated relative to neocortical binding has been reported, similar to that of nondemented autosomal dominant AD mutation carriers. However, it is not known whether changes in striatal and neocortical [C-11]PiB retention differ over time in a nondemented DS population when compared to changes in a nondemented elderly (NDE) population. The purpose of this work was to assess longitudinal changes in trajectories of A beta in a non-demented DS compared to an NDE cohort. The regional trajectories for anterior ventral striatum (AVS), frontal cortex, and precuneus [C-11]PiB retention were explored over time using linear mixed effects models with fixed effects of time, cohort, and time-by-cohort interactions and subject as random effects. Significant differences between DS and NDE cohort trajectories for all 3 region of interests were observed (p < 0.05), with the DS cohort showing a faster accumulation in the AVS and slower accumulation in the frontal cortex and precuneus compared to the NDE cohort. These data add to the previously reported distinct pattern of early striatal deposition not commonly seen in sporadic AD by demonstrating that individuals with DS may also accumulate A beta at a rate faster in the AVS when compared to NDE subjects. (C) 2018 Elsevier Inc. All rights reserved.
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