Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders

Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation

(2016) Bozena Kaminska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module

(2015) X. Li et al.   ALLERGY

The control of reactive oxygen species production by SHP-1 in oligodendrocytes

(2015) Ross C. Gruber et al.   GLIA

Taming the TCR: Antigen-Specific Immunotherapeutic Agents for Autoimmune Diseases

(2015) Evan L. Sauer et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment

(2015) Anika Stadtmann et al.   JOURNAL OF IMMUNOLOGY

SHP-1–Dependent Macrophage Differentiation Exacerbates Virus-Induced Myositis

(2015) Neva B. Watson et al.   JOURNAL OF IMMUNOLOGY

Genetic and epigenetic basis of psoriasis pathogenesis

(2015) Aditi Chandra et al.   MOLECULAR IMMUNOLOGY

The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis

(2015) Giulia Mallucci et al.   PROGRESS IN NEUROBIOLOGY

Phosphatase regulation of macrophage activation

(2015) Lisa K. Kozicky et al.   SEMINARS IN IMMUNOLOGY

Inhibition of Theiler's virus-induced apoptosis in infected murine macrophages results in necroptosis

(2015) Kyung-No Son et al.   VIRUS RESEARCH

Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma

(2015) Christos Demosthenous et al.   Oncotarget

Dynamic Redox Regulation of IL-4 Signaling

(2015) Gaurav Dwivedi et al.   PLoS Computational Biology

The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia

(2015) Stefan K. Alig et al.   PLoS One

Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1

(2015) Kun Xu et al.   PLoS One

Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization*

(2015) Wan-Yi Hsiao et al.   PLoS One

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects

(2015) Taolin Yi et al.   Oncotarget

Protein tyrosine phosphatases as potential therapeutic targets

(2014) Rong-jun He et al.   ACTA PHARMACOLOGICA SINICA

Neutrophilic Dermatoses: An Update

(2014) Afsaneh Alavi et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Conjugation-free, visual, and quantitative evaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III) complex

(2014) Hiroki Akiba et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The SHP-1 expression is associated with cytokines and psychopathological status in unmedicated first episode Schizophrenia patients

(2014) M. Pesce et al.   BRAIN BEHAVIOR AND IMMUNITY

PIPKI  targets to the centrosome and restrains centriole duplication

(2014) Q. Xu et al.   JOURNAL OF CELL SCIENCE

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

(2014) Sanae Ben Mkaddem et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish

(2014) Rubén Marín-Juez et al.   JOURNAL OF ENDOCRINOLOGY

SHP-2 Regulates Growth Factor Dependent Vascular Signalling and Function

(2014) Hanna Mannell et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Integrative biology of T cell activation

(2014) Bernard Malissen et al.   NATURE IMMUNOLOGY

Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways

(2014) Seok Hyun Cho et al.   PLoS One

Fine-tuning T cell receptor signaling to control T cell development

(2014) Guo Fu et al.   TRENDS IN IMMUNOLOGY

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

(2014) Tomoaki Ando et al.   Cell Reports

NF-κB signaling regulates myelination in the CNS

(2014) Thomas Blank et al.   Frontiers in Molecular Neuroscience

Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives

(2014) Grégory Caignard et al.   Genes

Reactive Nitrogen Species and Hydrogen Sulfide as Regulators of Protein Tyrosine Phosphatase Activity

(2013) Petr Heneberg   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration

(2013) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune Response

(2013) Norma Y. Hernández-Pedro et al.   Clinical & Developmental Immunology

Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

(2013) Clare L. Abram et al.   IMMUNITY

Shp1 regulates T cell homeostasis by limiting IL-4 signals

(2013) Dylan J. Johnson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmune animal models in the analysis of the CD47–SIRPα signaling pathway

(2013) Yoji Murata et al.   METHODS

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1

(2013) Jong-hyeon Kim et al.   NEUROBIOLOGY OF DISEASE

SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis

(2013) Li Zhou et al.   PLoS One

Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma Cells

(2013) Elisa Robles-Escajeda et al.   PLoS One

Exploration of biguanido–oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases

(2012) Liping Lu et al.   BIOMETALS

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

(2012) Stephanie M. Stanford et al.   IMMUNOLOGY

SHP-1 As a Critical Regulator of Mycoplasma pneumoniae-Induced Inflammation in Human Asthmatic Airway Epithelial Cells

(2012) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects

(2012) Chiharu Kumagai et al.   JOURNAL OF NEUROIMMUNOLOGY

Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells

(2011) Hae Sun Park et al.   BIOCHEMICAL PHARMACOLOGY

Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives

(2011) Ying Li et al.   BIOMETALS

A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on ‘clicked’ pseudo-glycopeptides

(2011) Jin-Wei Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients

(2011) George P. Christophi et al.   CLINICAL IMMUNOLOGY

Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities

(2011) Qingming Wang et al.   DALTON TRANSACTIONS

Inhibition protein tyrosine phosphatases by an oxovanadium glutamate complex, Na2[VO(Glu)2(CH3OH)](Glu = glutamate)

(2010) Liping Lu et al.   BIOMETALS

Novel SHP-1 Inhibitors Tyrosine Phosphatase Inhibitor-1 and Analogs with Preclinical Anti-Tumor Activities as Tolerated Oral Agents

(2010) S. Kundu et al.   JOURNAL OF IMMUNOLOGY

The Protein Tyrosine Phosphatase SHP-1 Modulates the Suppressive Activity of Regulatory T Cells

(2010) T. Iype et al.   JOURNAL OF IMMUNOLOGY

Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

(2010) Karsten W. Eriksen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

SHP-1 Deficient Mast Cells Are Hyperresponsive to Stimulation and Critical in Initiating Allergic Inflammation in the Lung

(2009) L. Zhang et al.   JOURNAL OF IMMUNOLOGY

Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype

(2009) George P Christophi et al.   LABORATORY INVESTIGATION

SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients

(2008) George P Christophi et al.   LABORATORY INVESTIGATION