Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs
出版年份 2016 全文链接
标题
Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs
作者
关键词
-
出版物
ILAR JOURNAL
Volume 57, Issue 2, Pages 144-156
出版商
Oxford University Press (OUP)
发表日期
2016-09-30
DOI
10.1093/ilar/ilw026
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds
- (2016) Karen Augustine-Rauch et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Advancements in zebrafish applications for 21st century toxicology
- (2016) Gloria R. Garcia et al. PHARMACOLOGY & THERAPEUTICS
- Animals and the 3Rs in toxicology research and testing
- (2015) WS Stokes HUMAN & EXPERIMENTAL TOXICOLOGY
- From cutting edge to guideline: A first step in harmonization of the zebrafish embryotoxicity test (ZET) by describing the most optimal test conditions and morphology scoring system
- (2015) Manon Beekhuijzen et al. REPRODUCTIVE TOXICOLOGY
- Developing predictive assays: The phenotypic screening “rule of 3”
- (2015) Fabien Vincent et al. Science Translational Medicine
- Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay
- (2015) Julieta M. Panzica-Kelly et al. TOXICOLOGICAL SCIENCES
- Influence of the perivitelline space on the quantification of internal concentrations of chemicals in eggs of zebrafish embryos (Danio rerio)
- (2014) Stephan Brox et al. AQUATIC TOXICOLOGY
- Primary Cell Cultures for Understanding Rat Epididymal Inflammation
- (2014) Robert E. Chapin et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Improvement of the evaluation method for teratogenicity using zebrafish embryos
- (2014) Akihito Yamashita et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Generation of male differentiated germ cells from various types of stem cells
- (2014) Jingmei Hou et al. REPRODUCTION
- More than just hormones: H295R cells as predictors of reproductive toxicity
- (2014) Jodi M. Maglich et al. REPRODUCTIVE TOXICOLOGY
- Fishing for Teratogens: A Consortium Effort for a Harmonized Zebrafish Developmental Toxicology Assay
- (2014) Jonathan S. Ball et al. TOXICOLOGICAL SCIENCES
- An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods
- (2014) Miguel A. Sogorb et al. TOXICOLOGY LETTERS
- Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening
- (2013) Jessica A. Palmer et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches
- (2012) Jan Willem van der Laan et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Alternative models in developmental toxicology
- (2012) Hyung-yul Lee et al. Systems Biology in Reproductive Medicine
- Development of a Streamlined Rat Whole Embryo Culture Assay for Classifying Teratogenic Potential of Pharmaceutical Compounds
- (2012) Cindy Zhang et al. TOXICOLOGICAL SCIENCES
- Establishment of a Molecular Embryonic Stem Cell Developmental Toxicity Assay
- (2012) Julieta M. Panzica-Kelly et al. TOXICOLOGICAL SCIENCES
- Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design
- (2011) Jason Thomson et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Zebrafish-As an integrative model for twenty-first century toxicity testing
- (2011) Nisha S. Sipes et al. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
- Contribution of myo-inositol and melatonin to human reproduction
- (2011) G. Carlomagno et al. European Journal of Obstetrics & Gynecology and Reproductive Biology
- In vitro production of functional sperm in cultured neonatal mouse testes
- (2011) Takuya Sato et al. NATURE
- Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?
- (2011) Kathleen Van den Bulck et al. REPRODUCTIVE TOXICOLOGY
- Mouse embryonic stem cell adherent cell differentiation and cytotoxicity (ACDC) assay
- (2011) Marianne Barrier et al. REPRODUCTIVE TOXICOLOGY
- Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds
- (2011) Ingrid W.T. Selderslaghs et al. REPRODUCTIVE TOXICOLOGY
- Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay – Progress report on phase I
- (2011) A.-L. Gustafson et al. REPRODUCTIVE TOXICOLOGY
- Zebrafish developmental screening of the ToxCast™ Phase I chemical library
- (2011) S. Padilla et al. REPRODUCTIVE TOXICOLOGY
- Zebrafish (Danio rerio) embryos as a model for testing proteratogens
- (2011) Stefan Weigt et al. TOXICOLOGY
- Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics
- (2011) N.C. Kleinstreuer et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies
- (2011) Sanne A.B. Hermsen et al. TOXICOLOGY IN VITRO
- Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)
- (2010) Jens C. Otte et al. AQUATIC TOXICOLOGY
- A dysmorphology score system for assessing embryo abnormalities in rat whole embryo culture
- (2010) Cindy X. Zhang et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Development of a zebrafish embryo teratogenicity assay and quantitative prediction model
- (2010) Kimberly C. Brannen et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays
- (2010) Karen Augustine-Rauch et al. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
- Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish
- (2010) Jared V Goldstone et al. BMC GENOMICS
- Dechorionation as a tool to improve the fish embryo toxicity test (FET) with the zebrafish (Danio rerio)
- (2010) Kirsten Henn et al. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
- The predictivity of preliminary embryo-fetal development (EFD) studies: results of a retrospective survey in Japanese pharmaceutical companies
- (2010) Noriko Okahashi et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Validation of a Rat Seminiferous Tubule Culture Model as a Suitable System for Studying Toxicant Impact on Meiosis Effect of Hexavalent Chromium
- (2010) Cendrine Geoffroy-Siraudin et al. TOXICOLOGICAL SCIENCES
- Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos
- (2010) Stefan Weigt et al. TOXICOLOGY
- Oxidative and Conjugative Xenobiotic Metabolism in Zebrafish Larvae In Vivo
- (2010) Huw S. Jones et al. Zebrafish
- In vitro post-meiotic germ cell development from human embryonic stem cells
- (2009) B. Aflatoonian et al. HUMAN REPRODUCTION
- Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates
- (2009) Xiaozhong Yu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry
- (2008) Jennifer A. Paquette et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish
- (2008) Robert Chapin et al. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Zebrafish: a predictive model for assessing drug-induced toxicity
- (2008) Patricia McGrath et al. DRUG DISCOVERY TODAY
- The in vitro growth and maturation of follicles
- (2008) H M Picton et al. REPRODUCTION
- Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)
- (2008) François Busquet et al. TOXICOLOGICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation