Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice

Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease

(2021) Lauren H. Fairley et al.   Frontiers in Immunology

Pulmonary inflammatory response to influenza virus infection in pigs is regulated by DAP12 and macrophage M1 and M2 phenotypes

(2020) Jagadish Hiremath et al.   CELLULAR IMMUNOLOGY

Resistance Exercise Decreases Amyloid Load and Modulates Inflammatory Responses in the APP/PS1 Mouse Model for Alzheimer’s Disease

(2020) Debora Hashiguchi et al.   JOURNAL OF ALZHEIMERS DISEASE

Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease

(2020) Martina Svensson et al.   Scientific Reports

Relationship Between Exercise and Alzheimer’s Disease: A Narrative Literature Review

(2020) Qing Meng et al.   Frontiers in Neuroscience

TREM2 ectodomain and its soluble form in Alzheimer’s disease

(2020) Jiaolong Yang et al.   Journal of Neuroinflammation

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

(2019) Julia K Götzl et al.   EMBO Molecular Medicine

Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice

(2019) Yubao Fan et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly via Hippocampal Microglia Modifications

(2019) Xianliang Zhang et al.   Frontiers in Aging Neuroscience

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Aβ-induced vulnerability propagates via the brain’s default mode network

(2019) Tharick A. Pascoal et al.   Nature Communications

Impacts of exercise intervention on different diseases and organ functions in mice

(2019) Shanshan Guo et al.   Journal of Sport and Health Science

Prophylactic effect of physical exercise on Aβ1–40-induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the hippocampus

(2019) Julia M. Rosa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer’s Disease Model Mice

(2019) Ruiqi Pang et al.   JOURNAL OF ALZHEIMERS DISEASE

Fresh push for ‘failed’ Alzheimer’s drug

(2019) Alison Abbott   NATURE

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

(2019) Nicholas J. Ashton et al.   Alzheimers Research & Therapy

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

(2019) Thomas M. Piers et al.   FASEB JOURNAL

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

The hypothalamus as the primary brain region of metabolic abnormalities in APP/PS1 transgenic mouse model of Alzheimer's disease

(2018) Hong Zheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diagnostic utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) in asymptomatic subjects at increased risk for Alzheimer’s disease

(2018) Alexander Drzezga et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

(2018) Bruno Dubois et al.   LANCET NEUROLOGY

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

(2018) Li Zhong et al.   Molecular Neurodegeneration

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

(2018) Yingyue Zhou et al.   Frontiers in Aging Neuroscience

Alzheimer’s disease

(2018) Richard Hodson   NATURE

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

(2018) Ione O. C. Woollacott et al.   Alzheimers Research & Therapy

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer's disease

(2017) Jung-Hoon Koo et al.   EXPERIMENTAL NEUROLOGY

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

(2017) Anne-Claire Dupont et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of exercise on brain activity during walking in older adults: a randomized controlled trial

(2017) Hiroyuki Shimada et al.   Journal of NeuroEngineering and Rehabilitation

[18F]FDG PET signal is driven by astroglial glutamate transport

(2017) Eduardo R Zimmer et al.   NATURE NEUROSCIENCE

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

(2017) Dominik Feuerbach et al.   NEUROSCIENCE LETTERS

Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury

(2017) Helena Morrison et al.   Scientific Reports

Effect of aerobic exercise on physical performance in patients with Alzheimer's disease

(2016) Nanna Aue Sobol et al.   Alzheimers & Dementia

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging

(2016) Jatta S Takkinen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice

(2016) Monica Sala-Rabanal et al.   JOURNAL OF PHYSIOLOGY-LONDON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury

(2016) M. Suarez-Calvet et al.   Science Translational Medicine

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

(2015) Panos Roussos et al.   Alzheimers & Dementia

Long-term treadmill exercise improves spatial memory of male appswe/ps1de9 mice by regulation of bdnf expression and microglia activation

(2015) Jingyu Xiong et al.   BIOLOGY OF SPORT

Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease

(2015) Cheril Tapia-Rojas et al.   BRAIN PATHOLOGY

Quantitative μPET Imaging of Cerebral Glucose Metabolism and Amyloidosis in the TASTPM Double Transgenic Mouse Model of Alzheimer’s Disease

(2015) Ann-Marie Waldron et al.   Current Alzheimer Research

Spatial patterns of atrophy, hypometabolism, and amyloid deposition in Alzheimer's disease correspond to dissociable functional brain networks

(2015) Michel J. Grothe et al.   HUMAN BRAIN MAPPING

What Are the Benefits of Exercise for Alzheimer’s Disease? A Systematic Review of the Past 10 Years

(2015) Salma S.S. Hernández et al.   JOURNAL OF AGING AND PHYSICAL ACTIVITY

Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice

(2015) Tzu-Wei Lin et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse

(2014) I.R. Macdonald et al.   Current Alzheimer Research

Exercise, Energy Intake, Glucose Homeostasis, and the Brain

(2014) H. van Praag et al.   JOURNAL OF NEUROSCIENCE

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

(2014) Susana Revilla et al.   NEUROPHARMACOLOGY

Microglial response to Alzheimer’s disease is differentially modulated by voluntary wheel running and enriched environments

(2013) J. J. Rodríguez et al.   Brain Structure & Function

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography

(2013) Santiago Rojas et al.   NEUROBIOLOGY OF AGING

Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

(2012) Bettina Linnartz et al.   GLIA

Gender, sex steroid hormones, and Alzheimer's disease

(2012) Rebekah S. Vest et al.   HORMONES AND BEHAVIOR

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice

(2011) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease

(2011) Géraldine Poisnel et al.   NEUROBIOLOGY OF AGING

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

(2009) Carla M. Yuede et al.   NEUROBIOLOGY OF DISEASE

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL