Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology

The α2 Na+/K+-ATPase isoform mediates LPS-induced neuroinflammation

(2020) J. A. Leite et al.   Scientific Reports

Induction of a Na+/K+-ATPase-Dependent Form of Autophagy Triggers Preferential Cell Death of Human Immunodeficiency Virus Type-1-Infected Macrophages

(2018) Gang Zhang et al.   Autophagy

Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation

(2018) Rupkatha Mukhopadhyay et al.   JOURNAL OF VIROLOGY

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

(2018) Peiying Li et al.   NEUROPHARMACOLOGY

Autophagy in ischemic stroke

(2018) Pei Wang et al.   PROGRESS IN NEUROBIOLOGY

Early Blood–Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/Venules

(2018) Angelika Hoffmann et al.   STROKE

Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases

(2018) Haixia Wen et al.   Cell Death & Disease

Release and uptake mechanisms of vesicular Ca2+ stores

(2018) Junsheng Yang et al.   Protein & Cell

DR-region of Na+/K+ ATPase is a target to treat excitotoxicity and stroke

(2018) Meimei Shi et al.   Cell Death & Disease

Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease

(2018) Ha-Lim Song et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Na+/K+-ATPase DR region-specific antibody protects U251 cells against hypoxia reperfusion-induced injury via the PI3K/AKT and ERK pathways

(2017) Huilin Gong et al.   Molecular Medicine Reports

HIF and HOIL-1L–mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury

(2017) Natalia D. Magnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease

(2017) Michael V. Clausen et al.   Frontiers in Physiology

Cysteine residues 244 and 458–459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions

(2017) Irina Yu. Petrushanko et al.   Redox Biology

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction

(2017) Motoi Kobayashi et al.   PLoS One

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

(2017) Paula F. Kinoshita et al.   Scientific Reports

Low dose ouabain stimulates Na K ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells

(2016) Corey J. Ketchem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Plant-derived cardiac glycosides: Role in heart ailments and cancer management

(2016) Seema Patel   BIOMEDICINE & PHARMACOTHERAPY

The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases

(2016) Yanling Yan et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition

(2016) Volker Vallon et al.   DIABETOLOGIA

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

“Oxygen Sensing” by Na,K-ATPase: These Miraculous Thiols

(2016) Anna Bogdanova et al.   Frontiers in Physiology

Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+/K+-ATPase Subunit Isoforms

(2016) Brian Roland Larsen et al.   Frontiers in Physiology

The divergent roles of autophagy in ischemia and preconditioning

(2015) Rui Sheng et al.   ACTA PHARMACOLOGICA SINICA

Importance of the Voltage Dependence of Cardiac Na/K ATPase Isozymes

(2015) Christopher M. Stanley et al.   BIOPHYSICAL JOURNAL

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

(2015) Mette Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ordered bulk degradation via autophagy

(2014) Jörn Dengjel et al.   Autophagy

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2

(2014) Annalisa Trenti et al.   BIOCHEMICAL PHARMACOLOGY

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMP-activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen-glucose deprivation

(2014) Bożena Gabryel et al.   CELL BIOLOGY INTERNATIONAL

Na+,K+-ATPase Isoform Selectivity for Digitalis-Like Compounds Is Determined by Two Amino Acids in the First Extracellular Loop

(2014) Karl M. Weigand et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

Preconditioning Stimuli Induce Autophagy via Sphingosine Kinase 2 in Mouse Cortical Neurons

(2014) Rui Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglia is a Key Player in the Reduction of Stroke Damage Promoted by the New Antithrombotic Agent Ticagrelor

(2014) Paolo Gelosa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Signaling function of Na,K-ATPase induced by ouabain against LPS as an inflammation model in hippocampus

(2014) Paula Fernanda Kinoshita et al.   Journal of Neuroinflammation

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Na+/H+ Exchangers and Intracellular pH in Perinatal Brain Injury

(2014) Cristina Uria-Avellanal et al.   Translational Stroke Research

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Frequency decoding of calcium oscillations

(2013) Erik Smedler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood–brain barrier divide

(2013) Ann-Marie Chacko et al.   Expert Opinion on Drug Delivery

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

IL-10 Deficiency Exacerbates the Brain Inflammatory Response to Permanent Ischemia without Preventing Resolution of the Lesion

(2013) Isabel Pérez-de Puig et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site

(2013) M. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning

(2012) Rui Sheng et al.   Autophagy

Effects of curcumin on levels of nitric oxide synthase and AQP-4 in a rat model of hypoxia–ischemic brain damage

(2012) Linsheng Yu et al.   BRAIN RESEARCH

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia–ischemia in neonatal hippocampal slice cultures

(2012) Qing Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

(2012) Yan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

S-Glutathionylation of the Na,K-ATPase Catalytic α Subunit Is a Determinant of the Enzyme Redox Sensitivity

(2012) Irina Yu. Petrushanko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome

(2012) S. Lacroix-Lamande et al.   JOURNAL OF IMMUNOLOGY

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

(2012)   LANCET

The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism

(2012) Deborah E. Bauer et al.   NEUROCHEMISTRY INTERNATIONAL

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

(2011) Mantong Zhao et al.   Cell Metabolism

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

AMPK -> ULK1 -> Autophagy

(2011) P. J. Roach   MOLECULAR AND CELLULAR BIOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Reactive oxygen species and ischemic cerebrovascular disease

(2011) Inan Olmez et al.   NEUROCHEMISTRY INTERNATIONAL

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts

(2010) Luis E.M. Quintas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase

(2010) Laure Yatime et al.   JOURNAL OF STRUCTURAL BIOLOGY

Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation

(2010) Natália Araújo Touza et al.   LIFE SCIENCES

Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke

(2010) Rohit Bhatia et al.   STROKE

Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase

(2009) Caroline N. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Cardiac Glycosides Inhibit p53 Synthesis by a Mechanism Relieved by Src or MAPK Inhibition

(2009) Z. Wang et al.   CANCER RESEARCH

Reversible Oxidative Modification

(2009) Gemma A. Figtree et al.   CIRCULATION RESEARCH

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

NaKtide, a Na/K-ATPase-derived Peptide Src Inhibitor, Antagonizes Ouabain-activated Signal Transduction in Cultured Cells

(2009) Zhichuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamate Transporter Coupling to Na,K-ATPase

(2009) E. M. Rose et al.   JOURNAL OF NEUROSCIENCE

Stroke treatment with alteplase given 3·0–4·5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial

(2009) Erich Bluhmki et al.   LANCET NEUROLOGY

Low-dose cardiotonic steroids increase sodium–potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia

(2009) Martin Oselkin et al.   NEUROSCIENCE LETTERS

Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets

(2009) A. Y. Bagrov et al.   PHARMACOLOGICAL REVIEWS

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Na+/K+-ATPase α subunits as new targets in anticancer therapy

(2008) Tatjana Mijatovic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The ion pathway through the opened Na+,K+-ATPase pump

(2008) Ayako Takeuchi et al.   NATURE