Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Article
Peripheral Vascular Disease
Matti Marklund, Fikru Tullu, Sudhir Raj Thout, Jie Yu, Tammy M. Brady, Lawrence J. Appel, Bruce Neal, Jason H. Y. Wu, Rachita Gupta
Summary: Modeling nationwide salt substitution in India consistently estimated substantial net benefits, preventing around 8% to 14% of annual cardiovascular deaths. Even allowing for potential hyperkalemia risks there were net benefits estimated for individuals with chronic kidney disease.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Hydrogen sulfide (H2S), previously recognized as a toxic gas, has now been acknowledged as an endogenously produced gaseous signaling molecule with diverse physiological and pathological functions at low concentrations. This review focuses on the renal production and functions of H2S, as well as its potential as a targeted therapeutic agent for renal pathologies such as hypertensive nephropathy, diabetic kidney disease, and water balance disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
R. Taylor Pickering, M. Loring Bradlee, Martha R. Singer, Lynn L. Moore
Summary: The study found that lower sodium intake (<2500 mg/d) was not associated with a reduced risk of cardiovascular disease, while higher potassium (>= 3000 mg/d) and magnesium (>= 320 mg/d) intake were associated with a 25% and 34% lower risk of CVD, respectively. Calcium intake >= 700 mg/d showed a non-significant 19% lower risk. The results emphasize the importance of potassium and magnesium for cardiovascular health.
Article
Oncology
Shutaro Sumiyoshi, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Simizu, Michihiro Kudo, Jun Kiuchi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
Summary: Na(+)/K+-ATPase & alpha;1 subunit (ATP1A1) exhibits aberrant expression in various types of cancer and its levels in specific tissues are associated with the development of cancer. However, the mechanism and signaling pathways underlying the effects of ATP1A1 in colon cancer (CC) have not been elucidated, and its prognostic impact remains unknown.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Hira Singh, Mauro Lombardo, Abhishek Goyal, Amrender Kumar, Anil Khar
Summary: The intake of diets with higher sodium and lower potassium has been considered a leading factor for the development of hypertension. Among fruits and vegetables, onion could be the ideal option as it contains high potassium content. Therefore, the evaluation of Indian onion cultivars for potassium and sodium content is important for preventing hypertension in the Indian population.
FRONTIERS IN NUTRITION
(2023)
Article
Peripheral Vascular Disease
Martin G. Schultz, Petr Otahal, Ann-Marie Kovacevic, Philip Roberts-Thomson, Tony Stanton, Christian Hamilton-Craig, Sudhir Wahi, Andre La Gerche, James L. Hare, Joseph Selvanayagam, Andrew Maiorana, Alison J. Venn, Thomas H. Marwick, James E. Sharman
Summary: The prevalence of exaggerated exercise blood pressure (EEBP) is higher in patients with type-2 diabetes (T2DM) compared to those without T2DM, independent of cardiovascular disease (CVD) and other risk factors. Clinicians supervising exercise testing in T2DM patients should be aware of the increased likelihood of EEBP and the need for follow-up care.
Article
Clinical Neurology
Daniel G. Calame, Cristina Moreno Vadillo, Seth Berger, Timothy Lotze, Marwan Shinawi, Javaher Poupak, Corina Heller, Julie Cohen, Richard Person, Aida Telegrafi, Chalongchai Phitsanuwong, Kaylene Fiala, Isabelle Thiffault, Florencia Del Viso, Dihong Zhou, Emily A. Fleming, Tomi Pastinen, Ali Fatemi, Sruthi Thomas, Samuel Pascual, Rosa J. Torres, Carmen Prior, Clara Gomez-Gonzalez, Saskia Biskup, James R. Lupski, Dragan Maric, Miguel Holmgren, Debra Regier, Sho T. Yano
Summary: Calame et al. report that genetic disorders of ATP1A3 can cause spasticity resembling cerebral palsy. They identify a genetic variant that leads to leakage of ions through the sodium-potassium pump and suggest it as a potential rare cause of spastic paraparesis. This study highlights the importance of ATP1A3 in neurological syndromes and provides insight into the molecular basis of phenotypic variability.
Article
Public, Environmental & Occupational Health
Andre Moreira-Rosario, Shamila Ismael, Ines Barreiros-Mota, Juliana Morais, Catarina Rodrigues, Ines Castela, Ines Curvelo Mendes, Maria Ines Soares, Luis Soares da Costa, Catarina Batista Oliveira, Tiago Henriques, Patricia Pinto, Debora Pita, Catarina Marques de Oliveira, Janaina Maciel, Thaina Serafim, Joao Araujo, Julio Cesar Rocha, Diogo Pestana, Marta P. Silvestre, Claudia Marques, Ana Faria, Jorge Polonia, Conceicao Calhau
Summary: The study compared the effectiveness of salt reduction and healthy lifestyle empowerment programs in reducing blood pressure, with the salt reduction program proving to be more effective in lowering blood pressure.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Zahra Mosallanezhad, Mohammad Jalali, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi
Summary: This study aimed to explore the potential associations between dietary sodium, potassium, and sodium-to-potassium ratio with the risk of cardiovascular disease in Iranian adults. The results showed that higher sodium intake was associated with an increased risk of CVD, while higher potassium intake was associated with a reduced risk of CVD.
Review
Environmental Sciences
Pawel Gac, Karolina Czerwinska, Piotr Macek, Aleksandra Jaremkow, Grzegorz Mazur, Krystyna Pawlas, Rafal Poreba
Summary: Research has highlighted the role of trace elements such as selenium and zinc in cardiovascular health, with some studies suggesting potential impact on cardiovascular morphology and function. However, there is currently no scientific evidence supporting supplementation of these trace elements for preventing cardiovascular diseases, highlighting the need for further research in this area.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Dong D. Wang, Yanping Li, Xuan-Mai T. Nguyen, Rebecca J. Song, Yuk-Lam Ho, Frank B. Hu, Walter C. Willett, Peter W. F. Wilson, Kelly Cho, J. Michael Gaziano, Luc Djousse
Summary: High sodium intake and low potassium intake are associated with a higher risk of CVD.
Article
Agriculture, Multidisciplinary
Jinghua Zhu, Zengxin Li, Meng Zhang, Weiwei Qin, Yoonseong Park, Yueping He
Summary: This study utilized RNA-seq to identify a set of transporter and receptor genes enriched in the excretory organs of the brown planthopper (BPH). RNA interference assays showed that the knockdown of certain genes significantly affected the survival and honeydew secretion of BPH. These genes may serve as potential targets for insect control.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Ravi B. Patel, Jozine M. Ter Maaten, Joao Pedro Ferreira, Finnian R. McCausland, Sanjiv J. Shah, Patrick Rossignol, Scott D. Solomon, Muthiah Vaduganathan, Milton Packer, Aliza Thompson, Norman Stockbridge, Faiez Zannad
Summary: Patients with chronic cardiovascular or metabolic diseases often have comorbid kidney disease, leading to worse long-term outcomes. Certain novel treatments have shown beneficial effects on both cardiac and kidney outcomes, sparking interest in formally acknowledging and defining composite cardio-kidney outcomes in future cardiovascular trials.
Review
Cardiac & Cardiovascular Systems
Dejana Popovic, Marija Bjelobrk, Milorad Tesic, Stefan Seman, Sisitha Jayasinghe, Andrew P. Hills, Abraham Samuel Babu, Djordje G. Jakovljevic, Lee Stoner, Cemal Ozemek, Samantha Bond, Mark A. Faghy, Nicolaas P. Pronk, Carl J. Lavie, Ross Arena
Summary: Traditional risk factors for cardiovascular disease have been long emphasized in preventive strategies, while psychological factors such as family stress and depression are under-appreciated in clinical practice guidelines. This article reviews the impact of acute and chronic stress on cardiovascular disease risk and emphasizes the importance of stress reduction approaches. Innovative approaches are needed to tackle the challenges posed by cardiovascular disease and stress.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Multidisciplinary Sciences
Komal Sodhi, Kyle Maxwell, Yanling Yan, Jiang Liu, Muhammad A. Chaudhry, Morghan Getty, Zijian Xie, Nader G. Abraham, Joseph I. Shapiro
Article
Cardiac & Cardiovascular Systems
Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi-Jian Xie, Joseph I. Shapiro, Jiang Liu
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Article
Cardiac & Cardiovascular Systems
Steven T. Haller, Yanling Yan, Christopher A. Drummond, Joe Xie, Jiang Tian, David J. Kennedy, Victoria Y. Shilova, Zijian Xie, Jiang Liu, Christopher J. Cooper, Deepak Malhotra, Joseph I. Shapiro, Olga V. Fedorova, Alexei Y. Bagrov
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Review
Physiology
Preeya T. Shah, Rebecca Martin, Yanling Yan, Joseph I. Shapiro, Jiang Liu
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Multidisciplinary Sciences
Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T. Shah, Asad A. Khawaja, Rebecca Martin, Tylor J. Robinette, Adee El-Hamdani, Michael W. Dodrill, Komal Sodhi, Christopher A. Drummond, Steven T. Haller, David J. Kennedy, Nader G. Abraham, Zijian Xie, Joseph I. Shapiro
SCIENTIFIC REPORTS
(2017)
Article
Peripheral Vascular Disease
Steven T. Haller, Christopher A. Drummond, Yanling Yan, Jiang Liu, Jiang Tian, Deepak Malhotra, Joseph I. Shapiro
AMERICAN JOURNAL OF HYPERTENSION
(2014)
Article
Biochemistry & Molecular Biology
Yu Wang, Qiqi Ye, Changxuan Liu, Jeffrey X. Xie, Yanling Yan, Fangfang Lai, Qiming Duan, Xiaomei Li, Jiang Tian, Zijian Xie
FREE RADICAL BIOLOGY AND MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Yanling Yan, Anna P. Shapiro, Steven Haller, Vinai Katragadda, Lijun Liu, Jiang Tian, Venkatesha Basrur, Deepak Malhotra, Zi-jian Xie, Nader G. Abraham, Joseph I. Shapiro, Jiang Liu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, Yanling Yan, Xiaoliang Wang, Preeya T. Shah, Asad A. Khawaja, Rebecca Martin, Tylor J. Robinette, Adee El-Hamdani, Michael W. Dodrill, Komal Sodhi, Christopher A. Drummond, Steven T. Haller, David J. Kennedy, Nader G. Abraham, Zijian Xie, Joseph I. Shapiro
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Yanling Yan, Jiayan Wang, Muhammad A. Chaudhry, Ying Nie, Shuyan Sun, Jazmin Carmon, Preeya T. Shah, Fang Bai, Rebecca Pratt, Cameron Brickman, Komal Sodhi, Jung Han Kim, Sandrine Pierre, Deepak Malhotra, Gary O. Rankin, Zi-jian Xie, Joseph I. Shapiro, Jiang Liu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Pauline Marck, Marco T. Pessoa, Yunhui Xu, Laura C. Kutz, Dominic M. Collins, Yanling Yan, Cierra King, Xiaoliang Wang, Qiming Duan, Liquan Cai, Jeffrey X. Xie, Jerry B. Lingrel, Zijian Xie, Jiang Tian, Sandrine Pierre
Summary: This study examined the response of mouse hearts to endogenous cardiotonic steroids. It was found that increased sensitivity to CTS can lead to elevated levels of cardiac carbonylated proteins, an increase in heart weight relative to tibia length, and an increase in myocyte cross-sectional area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pauline Marck, Yunhui Xu, Yanling Yan, Maddie Perdoncin, Cierra King, Qiming Duan, Jeff Paul McDermott, Liquan Cai, Jerry Lingrel, Gustavo V. Blanco, Zijian Xie, Sandrine V. Pierre
Meeting Abstract
Biochemistry & Molecular Biology
Pauline V. Marck, Yunhui Xu, Cierra King, Maddie Perdoncin, Yanling Yan, Gustavo Blanco, Liquan Cai, Jerry Lingrel, Zijian Xie, Sandrine V. Pierre
Review
Biochemistry & Molecular Biology
Jiang Liu, Yanling Yan, Ying Nie, Joseph I. Shapiro
