Structure–Activity Relationship of 3-Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors

Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017–present)

(2021) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure-activity relationships of pyrimidine nucleotides containing a 5′-α,β-methylene diphosphonate at the P2Y6 receptor

(2021) Paola Oliva et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives

(2021) Emma Scaletti et al.   Purinergic Signalling

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents

(2020) Flavia Varano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5′-nucleotidase (CD73) Inhibitors with Variable Binding Modes

(2020) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A3 Receptor Agonists

(2020) Dilip K. Tosh et al.   ACS Medicinal Chemistry Letters

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73

(2020) Joel W. Beatty et al.   JOURNAL OF MEDICINAL CHEMISTRY

CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers

(2020) Jerry B. Harvey et al.   Frontiers in Immunology

Discovery of AB680: A Potent and Selective Inhibitor of CD73

(2020) Kenneth V. Lawson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ecto-Nucleotidases CD73 and CD39

(2020) Jenna L. Jeffrey et al.   JOURNAL OF MEDICINAL CHEMISTRY

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production

(2020) Xiaohui Du et al.   JOURNAL OF MEDICINAL CHEMISTRY

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Fluorescent Probes for Ecto-5′-nucleotidase (CD73)

(2020) Constanze C. Schmies et al.   ACS Medicinal Chemistry Letters

Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

(2019) Anna Junker et al.   JOURNAL OF MEDICINAL CHEMISTRY

CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans

(2019) Pouya Joolharzadeh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Immunobiology, preliminary safety, and efficacy of CPI-006, an anti-CD73 antibody with immune modulating activity, in a phase 1 trial in advanced cancers.

(2019) Jason J. Luke et al.   JOURNAL OF CLINICAL ONCOLOGY

An Exceptionally Potent Inhibitor of Human CD73

(2019) Christine E. Bowman et al.   BIOCHEMISTRY

Synthesis of Substituted 5′‐Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73

(2019) Rayane Ghoteimi et al.   ChemMedChem

Complex regulation of ecto-5′-nucleotidase/CD73 and A2AR-mediated adenosine signaling at neurovascular unit: A link between acute and chronic neuroinflammation

(2019) Nadezda Nedeljkovic   PHARMACOLOGICAL RESEARCH

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

(2019) Selena Vigano et al.   Frontiers in Immunology

Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73)

(2019) Marquet Minor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A 2A receptor over‐activation in a rat model of Parkinson's disease

(2019) Marta Carmo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Survey of ribose ring pucker of signaling nucleosides and nucleotides

(2019) Veronica Salmaso et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss

(2019) Yu-Ru V. Shih et al.   Science Advances

Potential of CD73 as a target for cancer immunotherapy

(2019) Farhad Jadidi-Niaragh   Immunotherapy

The CD73/Ado System—A New Player in RT Induced Adverse Late Effects

(2019) Simone de Leve et al.   Cancers

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

AB680, a potent and selective CD73 small molecule inhibitor, reverses the AMP/adenosine-mediated impairment of immune effector cell activation by immune checkpoint inhibitors

(2018) U. Schindler et al.   EUROPEAN JOURNAL OF CANCER

CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade

(2018) Limo Chen et al.   Cancer Discovery

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

(2018) Fan Meng et al.   BRAIN

Pyrimidine nucleotides containing a (S)-methanocarba ring as P2Y6 receptor agonists

(2017) Kiran S. Toti et al.   MedChemComm

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

CD73 Inhibition Shifts Cardiac Macrophage Polarization toward a Microbicidal Phenotype and Ameliorates the Outcome of Experimental Chagas Cardiomyopathy

(2016) Nicolás Eric Ponce et al.   JOURNAL OF IMMUNOLOGY

Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

(2016) Patrycja Koszałka et al.   PLoS One

Adenosine A2A receptor and ecto-5′-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE)

(2016) Aurora R. Barros-Barbosa et al.   Purinergic Signalling

Targeting CD73 in the tumor microenvironment with MEDI9447

(2016) Carl M. Hay et al.   OncoImmunology

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors

(2015) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid Synthesis of Alkoxyamine Hydrochloride Derivatives from Alkyl Bromide andN,N′-Di-tert-butoxycarbonylhydroxylamine [(Boc)2NOH]

(2014) P. Suresh Jayasekara et al.   SYNTHETIC COMMUNICATIONS

A new, sensitive ecto-5′-nucleotidase assay for compound screening

(2013) Marianne Freundlieb et al.   ANALYTICAL BIOCHEMISTRY

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Revised AMBER Parameters for Bioorganic Phosphates

(2012) T. Steinbrecher et al.   Journal of Chemical Theory and Computation

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

Synthesis of unsymmetrical biaryl ureas from N-carbamoylimidazoles: kinetics and application

(2012) Tristan Rawling et al.   TETRAHEDRON

NT5EMutations and Arterial Calcifications

(2011) Cynthia St. Hilaire et al.   NEW ENGLAND JOURNAL OF MEDICINE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Wordom: A user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces

(2010) Michele Seeber et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Functionalized Congener Approach to the Design of Ligands for G Protein-Coupled Receptors (GPCRs)

(2009) Kenneth A. Jacobson   BIOCONJUGATE CHEMISTRY

ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale

(2009) M. J. Harvey et al.   Journal of Chemical Theory and Computation