Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

(2020) Oddrun Elise Olsen et al.   Biomolecules

Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling

(2020) Chen Xie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp

(2019) Jianfei Zhang et al.   International Journal of Oral Science

Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?

(2019) Jonas Halver et al.   Frontiers in Pharmacology

Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia

(2018) Hartmut Beck et al.   ChemMedChem

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

(2018) Martin J. Pfeiffer et al.   Nature Communications

Id genes are essential for early heart formation

(2017) Thomas J. Cunningham et al.   GENES & DEVELOPMENT

Bone Morphogenetic Protein–Based Therapeutic Approaches

(2017) Jonathan W. Lowery et al.   Cold Spring Harbor Perspectives in Biology

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

(2016) Jyoti Rao et al.   Cell Stem Cell

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation

(2016) Lingling Feng et al.   Cell Reports

Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

(2015) Rajarshi Samanta et al.   CHEMICAL COMMUNICATIONS

Medicinal Chemistry Approaches to Heart Regeneration

(2015) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

(2015) Matthew J Birket et al.   NATURE BIOTECHNOLOGY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Bone Morphogenetic Proteins

(2014) A.C. Carreira et al.   JOURNAL OF DENTAL RESEARCH

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe

(2013) Darren W. Engers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment

(2013) W. Cai et al.   GENES & DEVELOPMENT

Identification of Small Molecule Activators of BMP Signaling

(2013) Karen Vrijens et al.   PLoS One

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

(2012) Erik Willems et al.   Cell Stem Cell

Synthesis and SAR of b-Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFβ Signaling

(2012) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardiopoietic Factors

(2011) Michela Noseda et al.   CIRCULATION RESEARCH

Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3β-dependent and β-catenin-independent mechanism

(2010) Toru Fukuda et al.   DIFFERENTIATION

Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways

(2010) Edgardo Rodríguez-Carballo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMPs: From Bone to Body Morphogenetic Proteins

(2010) D. Obradovic Wagner et al.   Science Signaling

In VivoStructure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors

(2009) Jijun Hao et al.   ACS Chemical Biology