Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia

Mass spectrometric characterization of the hypoxia-inducible factor (HIF) stabilizer drug candidate BAY 85-3934 (molidustat) and its glucuronidated metabolite BAY-348, and their implementation into routine doping controls

(2016) Josef Dib et al.   Drug Testing and Analysis

Biocatalysis at Work: Applications in the Development of Sagopilone

(2015) Kathrin Gottfried et al.   ChemMedChem

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

(2015) Patrick H. Maxwell et al.   Nature Reviews Nephrology

Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects

(2014) Ingo Flamme et al.   PLoS One

Cardiovascular Toxicity of Epoetin-Alfa in Patients with Chronic Kidney Disease

(2013) Peter A. McCullough et al.   AMERICAN JOURNAL OF NEPHROLOGY

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Emerging technologies for metabolite generation and structural diversification

(2013) Kevin P. Cusack et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses

(2013) Michael H. Rabinowitz   JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

HIF prolyl hydroxylase inhibitors for anemia

(2011) Eugene Muchnik et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Microbial production of phase I and phase II metabolites of midazolam

(2011) Cyrille Marvalin et al.   XENOBIOTICA

Regulation of erythropoietin production

(2010) Wolfgang Jelkmann   JOURNAL OF PHYSIOLOGY-LONDON

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Erythropoiesis-Stimulating Agents — Time for a Reevaluation

(2010) Ellis F. Unger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbial production of phase I and phase II metabolites of propranolol

(2010) Cyrille Marvalin et al.   XENOBIOTICA

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

(2010) Andy Zöllner et al.   Bioanalysis

Glucuronide Production by Whole-Cell Biotransformation Using Genetically Engineered Fission Yeast Schizosaccharomyces pombe

(2009) C.-A. Dragan et al.   DRUG METABOLISM AND DISPOSITION