Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation

(2019) Daniel S. J. Miller et al.   JOURNAL OF CELL SCIENCE

Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity

(2019) Erich J. Goebel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable signaling activity by FOP ACVR1 mutations

(2018) Julia Haupt et al.   BONE

BMPR2 inhibits activin and BMP signaling via wild-type ALK2

(2018) Oddrun Elise Olsen et al.   JOURNAL OF CELL SCIENCE

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

(2018) Anassuya Ramachandran et al.   eLife

ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2

(2018) Lisa Traeger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural insights into BMP receptors: Specificity, activation and inhibition

(2016) David Yadin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding

(2016) Senem Aykul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand–Receptor Interactions and Antagonist Activity

(2016) Senem Aykul et al.   JOURNAL OF MOLECULAR BIOLOGY

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B

(2015) Oddrun Elise Olsen et al.   Cell Communication and Signaling

Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes

(2015) Senem Aykul et al.   PLoS One

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

(2015) Kyosuke Hino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

The role of bone morphogenetic proteins in myeloma cell survival

(2014) Toril Holien et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin

(2014) O E Olsen et al.   Blood Cancer Journal

Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe

(2013) Darren W. Engers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A New Class of Small Molecule Inhibitor of BMP Signaling

(2013) Caroline E. Sanvitale et al.   PLoS One

Controlling Long-Term Signaling: Receptor Dynamics Determine Attenuation and Refractory Behavior of the TGF-  Pathway

(2013) P. Vizan et al.   Science Signaling

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Addiction to c-MYC in multiple myeloma

(2012) T. Holien et al.   BLOOD

Phosphatases in SMAD regulation

(2012) David L. Bruce et al.   FEBS LETTERS

Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

(2011) Cheng Hua Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC

(2011) T Holien et al.   LEUKEMIA

Bone morphogenetic protein receptors and signal transduction

(2009) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

CDK2 Phosphorylation of Smad2 Disrupts TGF-  Transcriptional Regulation in Resistant Primary Bone Marrow Myeloma Cells

(2009) L. B. Baughn et al.   JOURNAL OF IMMUNOLOGY

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

(2008) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells

(2007) U.-M. Fagerli et al.   BLOOD