Innate Immune Memory and the Host Response to Infection

IL‐38 prevents induction of trained immunity by inhibition of mTOR signaling

(2021) Dennis M. Graaf et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate immune memory mediates increased susceptibility to Alzheimer’s disease-like pathology in sepsis surviving mice

(2021) Virginia L. De Sousa et al.   BRAIN BEHAVIOR AND IMMUNITY

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

(2021) Giulio Cavalli et al.   Cell Reports

Establishment, maintenance, and recall of inflammatory memory

(2021) Samantha B. Larsen et al.   Cell Stem Cell

β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages

(2021) Cody L. Stothers et al.   JOURNAL OF IMMUNOLOGY

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

(2020) Bérengère de Laval et al.   Cell Stem Cell

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein

(2020) Samuel T. Keating et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

(2020) Simone J.C.F.M. Moorlag et al.   Cell Reports

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

(2020) Samuel T. Keating et al.   Cell Reports

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

(2020) Branko Cirovic et al.   Cell Host & Microbe

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations

(2020) Ryne C. Ramaker et al.   GENOME RESEARCH

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

(2020) Jesse J. Balic et al.   Nature Communications

OxLDL-mediated immunologic memory in endothelial cells

(2020) Yahya Sohrabi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2

(2020) Sanja Glisic et al.   JOURNAL OF PROTEOME RESEARCH

Immunometabolic control of trained immunity

(2020) Niels P. Riksen et al.   MOLECULAR ASPECTS OF MEDICINE

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

(2020) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Innate lymphoid cell memory

(2019) Xianwei Wang et al.   Cellular & Molecular Immunology

Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters

(2019) Rui Sun et al.   JOURNAL OF IMMUNOLOGY

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation

(2019) Orhan Rasid et al.   Cell Reports

Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine

(2018) Stephanie F. James et al.   ANNALS OF PHARMACOTHERAPY

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

Innate immune memory: An evolutionary perspective

(2018) Benjamin Gourbal et al.   IMMUNOLOGICAL REVIEWS

The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism

(2018) Benjamin A. Fensterheim et al.   JOURNAL OF IMMUNOLOGY

Long-term reprogramming of the innate immune system

(2018) Jorge Dominguez-Andres et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon stimulation creates chromatin marks and establishes transcriptional memory

(2018) Rui Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

IFN-γ immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans

(2018) Chrissy M. Leopold Wager et al.   PLoS Pathogens

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection

(2017) Benjamin A. Fensterheim et al.   JOURNAL OF IMMUNOLOGY

Rapid Protective Effects of Early BCG on Neonatal Mortality Among Low Birth Weight Boys: Observations From Randomized Trials

(2017) Sofie Biering-Sørensen et al.   JOURNAL OF INFECTIOUS DISEASES

Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer

(2017) Mihai G. Netea et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney

(2017) Takashi Hato et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Monocyte and macrophage immunometabolism in atherosclerosis

(2017) Laszlo Groh et al.   Seminars in Immunopathology

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

(2017) Jorge Domínguez-Andrés et al.   PLoS Pathogens

Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response

(2016) Helen Weavers et al.   CELL

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

(2016) Boris Novakovic et al.   CELL

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

(2016) Harding H. Luan et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Macrophages: sentinels and regulators of the immune system

(2016) Lars Franken et al.   CELLULAR MICROBIOLOGY

In VitroExperimental Model of Trained Innate Immunity in Human Primary Monocytes

(2016) Siroon Bekkering et al.   Clinical and Vaccine Immunology

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of MyD88- and TRIF-dependent signaling in monophosphoryl lipid A-induced expansion and recruitment of innate immunocytes

(2016) Antonio Hernandez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

(2016) Michael I. Love et al.   NUCLEIC ACIDS RESEARCH

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Key mechanisms governing resolution of lung inflammation

(2016) C. T. Robb et al.   Seminars in Immunopathology

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity

(2016) Karen A.O. Martins et al.   EBioMedicine

Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis

(2015) María José de Castro et al.   CLINICAL INFECTIOUS DISEASES

Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury

(2015) Julia K. Bohannon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

(2015) Nergiz Dogan et al.   Epigenetics & Chromatin

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

(2014) Daniela C. Ifrim et al.   Clinical and Vaccine Immunology

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

(2014) Johanneke Kleinnijenhuis et al.   CLINICAL IMMUNOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

(2014) Lin Luo et al.   Nature Communications

Metabolic Reprograming in Macrophage Polarization

(2014) Silvia Galván-Peña et al.   Frontiers in Immunology

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

The Toll-Like Receptor 4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection

(2011) Christopher D. Romero et al.   INFECTION AND IMMUNITY

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

(2011) T. D. Troutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin modification acts as a memory for systemic acquired resistance in the plant stress response

(2010) Michal Jaskiewicz et al.   EMBO REPORTS

Adaptive immunity

(2010) Francisco A. Bonilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Monocytes and Macrophages Regulate Immunity through Dynamic Networks of Survival and Cell Death

(2010) Arti Parihar et al.   Journal of Innate Immunity

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Pretreatment with the Gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Staphylococcus aureus

(2008) E D. Murphey et al.   CRITICAL CARE MEDICINE

Pretreatment with the Gram-positive bacterial cell wall molecule peptidoglycan improves bacterial clearance and decreases inflammation and mortality in mice challenged with Pseudomonas aeruginosa

(2008) E.D. Murphey et al.   MICROBES AND INFECTION

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark