Article
Multidisciplinary Sciences
Toshihiko Kobayashi, Dat Nguyen-Tien, Yuriko Sorimachi, Yuki Sugiura, Takehiro Suzuki, Hitomi Karyu, Shiho Shimabukuro-Demoto, Tatsuki Uemura, Tadashi Okamura, Tomohiko Taguchi, Kohjiro Ueki, Norihiro Kato, Nobuhito Goda, Naoshi Dohmae, Keiyo Takubo, Makoto Suematsu, Noriko Toyama-Sorimachi
Summary: The amino acid and oligopeptide transporter SLC15A4 plays a critical role in regulating inflammatory responses and cytokine production in immune cells. Loss of SLC15A4 leads to metabolic imbalances, impacting glutamine metabolism and the tricarboxylic acid cycle. Additionally, SLC15A4 is essential for AMPK activation and maintaining respiratory homeostasis in macrophages.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Fisheries
Nguyen Bao Trung, Fan-Hua Nan, Meng-Chou Lee, Jiun-Yan Loh, Hong-Yi Gong, Ming-Wei Lu, Ho Thi Hang, Yu-Lin Lin, Po-Tsang Lee
Summary: TLR18 is expressed in all tissues, with the highest levels in the intestine and the lowest in the liver. It is up-regulated in immune-related organs after bacterial and poly I:C challenges, and in THK cells after LPS stimulation. TLR18 localizes in the intracellular compartment, and interacts with MyD88 and TRIF as adaptors. Constitutively active TLR18 induces the production of various effectors like cytokines and antimicrobial peptides in THK cells.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Bin Shen, Siyu Zhang, Fengxin Li, Jing Xu, Yuqin Zhang, Jianshe Zhang
Summary: This study conducted functional analyses for two ISG15 homologues in Larimichthys crocea and found that they play important roles in immune regulation and host immune defense against viral and bacterial infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Denho Ravi, Erato Ntinopoulou, Nessim Guetta, Manuela Weier, Verena Vogel, Barbara Spellerberg, Parham Sendi, Sandrine Gremlich, Thierry Roger, Eric Giannoni
Summary: This study compares the response of newborn and adult macrophages to GBS. The findings show that newborn macrophages exhibit higher levels of cytokine release in response to GBS, and may play a significant role in the progression of GBS infection in newborns.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiroyuki Tada, Takashi Nishioka, Rina Ishiyama, Li-Ting Song, Sakura Onoue, Kazuyoshi Kawahara, Eiji Nemoto, Kenji Matsushita, Shunji Sugawara
Summary: In this study, the effects of mast cell extracellular traps (MCETs) released from mast cells after infection with periodontal pathogen Fusobacterium nucleatum were investigated. F. nucleatum induced the release of MCETs from mast cells, and these MCETs expressed macrophage migration inhibitory factor (MIF). Importantly, MIF bound to MCETs induced the production of proinflammatory cytokines by monocytic cells. These findings suggest that MIF expressed on MCETs released upon infection with F. nucleatum promotes inflammatory responses associated with the pathogenesis of periodontal disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Immunology
Attinder Chadha, Kris Chadee
Summary: Protozoan parasites evade host defenses by hijacking host cellular signaling pathways and transcription factors, with the NF-kappa B pathway being a key target. These parasites manipulate the NF-kappa B pathway to thwart immune responses and ensure survival in the host.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fa Dai, Ming Guo, Yina Shao, Chenghua Li
Summary: The study revealed that the flagellum protein of Vibrio splendidus destroyed tissue structure and promoted apoptosis in sea cucumber, with the novel receptor AjTmod playing a role in activating the p38 MAPK signaling pathway to induce p53-dependent coelomocyte apoptosis in Echinodermata.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Elisa Reimer, Markus Stempel, Baca Chan, Hanna Bley, Melanie M. Brinkmann
Summary: PTP1B positively regulates the type I IFN response by promoting secretion of key antiviral cytokines, even though its deficiency did not affect Ifnb1 transcription. Macrophages from PTP1B-knockout mice accumulated type I IFN, indicating a role for PTP1B in mediating its secretion.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ahmet K. Korkaya, Jeffrey Fischer, Anthony Peppers, Sean M. Crosson, Manira Rayamajhi, Edward A. Miao, Albert S. Baldwin, Jennifer W. Bradford
Summary: This study describes a novel mouse model, p65(fl/fl)/LysMCre, which lacks p65 protein in bone marrow-derived macrophages, resulting in deficiencies in NF-kappa B signaling and abnormal macrophage function. This model holds great potential for investigating NF-kappaB signaling in macrophages in various biological and biomedical studies.
Article
Biology
Ratthakorn Chaiwut, Watchara Kasinrerk
Summary: This study investigated the regulation of proinflammatory cytokines and chemokines in human primary monocytes and T lymphocytes by various concentrations of Lipopolysaccharide (LPS). The results showed that even very low concentrations of LPS could modulate cytokine production in monocytes but not in T lymphocytes. The study highlights the importance of thorough screening for endotoxins in recombinant proteins used for immune function research.
BMC RESEARCH NOTES
(2022)
Article
Parasitology
F. Li, X. L. Li, S. J. Chen, C. Tan, S. P. Mei, H. G. Jia, Z. H. Song, R. Q. Zhou
Summary: Exposure of mouse macrophages to excretory/secretory proteins of adult T. canis induced the expression of NOD1, RIP2, and NF-kappa B and modulated the production of pro-inflammatory cytokines. This suggests that the ES proteins may affect host immune responses through the NOD1-RIP2-NF-kappa B signaling pathway.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Surgery
Chao Wei, Li Ma, Demeng Xiang, Cixin Huang, Huijin Wang, Xin Wang, Sai Zhang, Xiaolin Qi, Weiyun Shi, Hua Gao
Summary: Enhanced autophagy can alleviate corneal allograft rejection by inhibiting NLRP3 inflammasome activity through NLRP3 degradation. Blocking autophagy restores NLRP3 inflammasome activity, suggesting that autophagy plays a critical role in treating corneal allograft rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Darja Kanduc
Summary: The study investigates the role of molecular mimicry in the cytokine storms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It found that the SARS-CoV-2 spike glycoprotein shares numerous pentapeptides with anti-inflammatory proteins, potentially leading to cytokine storms.
Article
Clinical Neurology
Huntington Potter, Jonathan H. Woodcock, Timothy D. Boyd, Christina M. Coughlan, John R. O'Shaughnessy, Manuel T. Borges, Ashesh A. Thaker, Balaibail A. Raj, Katarzyna Adamszuk, David Scott, Vanesa Adame, Paige Anton, Heidi J. Chial, Helen Gray, Joseph Daniels, Michelle E. Stocker, Stefan H. Sillau
Summary: Inflammation may play a role in AD, and the innate immune system has the potential to be a therapeutic target. Research has found that GM-CSF/sargramostim treatment for AD can improve cognitive function and ameliorate pathological markers.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2021)