Review
Microbiology
Qinglin Zhang, Qizhen Jia, Wenying Gao, Wenyan Zhang
Summary: This article summarizes the function of DUBs in modulating viral infection and highlights their importance as therapeutic targets for antiviral treatment.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
David P. Maison, Youping Deng, Mariana Gerschenson
Summary: The SARS-CoV-2 pandemic and COVID-19 disease have had a global impact, sparking a significant surge in research. To evaluate future approaches, understanding the host immune response and viral antagonism is crucial. This review summarizes current knowledge on SARS-CoV-2, focusing on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. Efforts should be directed towards current research to develop treatments and prepare for future outbreaks.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Iwona T. Myszor, Gudmundur Hrafn Gudmundsson
Summary: The innate immune system of the airway epithelium consists of multiple components that work together to protect the host from invading pathogens. Modulating innate immune responses in the airway epithelium to boost host defenses and enhance immune responses is an alternative approach to standard antibiotics. This review discusses the possibilities of such modulation for host-directed therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Masoud Shamaei, Mehdi Mirsaeidi
Summary: The incidence and prevalence of NTM infections are increasing worldwide, posing a major public health threat. Macrophages play a crucial role in immune responses against NTM, including phagocytosis, antigen presentation, and downstream activation of adaptive immune responses.
INFECTION AND IMMUNITY
(2021)
Review
Immunology
Yuhan Zhong, Xiao Zhong, Liangjun Qiao, Hong Wu, Chang Liu, Ting Zhang
Summary: The Z alpha domain is a compact α/β structure that specifically binds to nucleic acids with a left-handed helical conformation. It has been identified in several proteins, including ADAR1 and ZBP1, which play important roles in immune response regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Klara Kubelkova, Vanda Bostik, Lokesh Joshi, Ales Macela
Summary: The cellular and humoral mechanisms of natural immunity play a crucial role in the defense processes of an organism by recognizing pathogen-associated molecular patterns and damage-associated molecular patterns. Recognition of these patterns activates the innate immune defense mechanisms, but if not regulated properly, can lead to damaging inflammation. This review highlights the integration of innate immune recognition, cell-autonomous stress response, infection, and tumorigenesis.
Review
Immunology
Wanhai Qin, Brendon P. Scicluna, Tom van der Poll
Summary: DNA methylation plays a key role in the immune response to bacteria by regulating gene expression. Despite being traditionally considered a stable modification, accumulating evidence suggests that DNA methylation patterns can change rapidly in response to different environments and pathogens. Proteins regulating DNA methylation, such as DNA methyltransferases and ten-eleven translocation methylcytosine dioxygenases, may also be modulated by bacteria during infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Ya-Lang Huang, Ming-Ting Huang, Pei-Shan Sung, Teh-Ying Chou, Ruey-Bing Yang, An-Suei Yang, Chung-Ming Yu, Yu-Wen Hsu, Wei-Chiao Chang, Shie-Liang Hsieh
Summary: Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress viral replication, and increase mice survival rate after flu infection infection.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Zhengdong Gao, Yaxiao Liu, Lekai Zhang, Zizhuo Yang, Linchen Lv, Shuai Wang, Lipeng Chen, Nan Zhou, Yaofeng Zhu, Xuewen Jiang, Benkang Shi, Yan Li
Summary: This study explores the interaction between nociceptor neurons and the bladder immune system during urinary tract infections (UTIs). The researchers found that uropathogenic Escherichia coli (UPEC) and its pathogenic factor directly stimulate nociceptor neurons, causing the neurons to release calcitonin gene-related peptide (CGRP) and suppress immune responses. By blocking neuronal inhibition, UTI can be prevented.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Wei Li, Hongnuan Wang, Shijun J. Zheng
Summary: Influenza virus and coronavirus are important respiratory viruses that cause serious diseases in humans and animals. Understanding the relationship between viral infection and host innate immunity is crucial for effective control strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yafeng Dou, Yan Xie, Lingyun Zhang, Sheng Liu, Dandan Xu, Yuying Wei, Yongshuai Li, Xiao-Lian Zhang
Summary: This study explores the role of a protein called PPE68 in the intracellular survival of Mycobacterium tuberculosis (Mtb) in macrophages. The researchers found that PPE68 is essential for efficient Mtb intracellular survival and that a macrophage protein called MKRN1 interacts with PPE68 to facilitate its ubiquitination. This ubiquitination of PPE68 suppresses immune responses and helps Mtb evade the immune system. The findings reveal a previously unrecognized mechanism of Mtb immune escape and suggest that targeting the interaction between MKRN1 and Mtb PPE proteins could be a potential therapeutic strategy for tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuexiu Zhang, Li-Sheng Zhang, Qing Dai, Phylip Chen, Mijia Lu, Elizabeth L. Kairis, Valarmathy Murugaiah, Jiayu Xu, Rajni Kant Shukla, Xueya Liang, Zhongyu Zou, Estelle Cormet-Boyaka, Jianming Qiu, Mark E. Peeples, Amit Sharma, Chuan He, Jianrong Li
Summary: The role of RNA m(5)C methylation in innate immunity against viruses has been explored. Depletion of NSUN2, an m(5)C methyltransferase, inhibits viral replication and gene expression through enhancing the type I interferon response. NSUN2 depletion reduces m(5)C methylation of noncoding RNAs (ncRNAs), leading to their upregulation and stimulating the IFN response. These findings suggest that RNA m(5)C methylation controls antiviral innate immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Lim Jack Lee, Thamil Vaani Komarasamy, Nur Amelia Azreen Adnan, William James, Vinod R. M. T. Balasubramaniam
Summary: Zika virus has received global attention due to its association with severe neurological syndromes and congenital abnormalities, as well as its ability to spread through sexual and transplacental transmission. The lack of approved antiviral or vaccine for ZIKV highlights the importance of ongoing research and development efforts to prepare for potential future outbreaks. The virus has developed sophisticated mechanisms to evade host immune responses, making it crucial to understand the interactions between ZIKV and human host pathways for successful infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
A. J. A. T. Braat, S. C. Kappadath, H. Ahmadzadehfar, C. L. Stothers, A. Frilling, C. M. Deroose, P. Flamen, D. B. Brown, D. Y. Sze, A. Mahvash, M. G. E. H. Lam
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2019)
Article
Critical Care Medicine
Satoshi Fukuda, Koji Ihara, Julia K. Bohannon, Antonio Hernandez, Naeem K. Patil, Liming Luan, Cody Stothers, Ryan Stark, Donald S. Prough, David N. Herndon, Edward R. Sherwood, Perenlei Enkhbaatar
Article
Critical Care Medicine
Antonio Hernandez, Liming Luan, Cody L. Stothers, Naeem K. Patil, Jessica B. Fults, Benjamin A. Fensterheim, Yin Guo, Jingbin Wang, Edward R. Sherwood, Julia K. Bohannon
CRITICAL CARE MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
A. J. A. T. Braat, H. Ahmadzadehfar, S. C. Kappadath, C. L. Stothers, A. Frilling, C. M. Deroose, P. Flamen, D. B. Brown, D. Y. Sze, A. Mahvash, M. G. E. H. Lam
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Review
Pharmacology & Pharmacy
Antonio Hernandez, Naeem K. Patil, Cody L. Stothers, Liming Luan, Margaret A. McBride, Allison M. Owen, Katherine R. Burelbach, David L. Williams, Edward R. Sherwood, Julia K. Bohannon
PHARMACOLOGICAL RESEARCH
(2019)
Review
Immunology
Margaret A. McBride, Allison M. Owen, Cody L. Stothers, Antonio Hernandez, Liming Luan, Katherine R. Burelbach, Tazeen K. Patil, Julia K. Bohannon, Edward R. Sherwood, Naeem K. Patil
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Cody L. Stothers, Katherine R. Burelbach, Allison M. Owen, Naeem K. Patil, Margaret A. McBride, Julia K. Bohannon, Liming Luan, Antonio Hernandez, Tazeen K. Patil, David L. Williams, Edward R. Sherwood
Summary: Beta-glucan induces trained immunity in macrophages, enhancing protection against infection through increased recruitment of innate leukocytes and local clearance of bacteria, sustained by metabolic and functional changes.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Antonio Hernandez, Jing Zhou, Julia K. Bohannon, Margaret A. McBride, Katherine N. Gibson-Corley, Naeem K. Patil, Allison M. Owen, Katherine R. Burelbach, Edward R. Sherwood
Summary: Intrapulmonary treatment with 3D PHAD enhances innate immunity in the lung and improves resistance to Klebsiella pneumoniae pneumonia.
Article
Anesthesiology
Christina Anne Jelly, Jacob C. Clifton, Frederic T. Billings IV, Antonio Hernandez, Andrew J. Schaffer, Matthew E. Shotwell, Robert E. Freundlich
Summary: This study aimed to investigate the association between opioid-sparing anesthetics and postoperative delirium. The use of the multimodal pain regimen was not associated with delirium, except for acetaminophen, which was associated with reduced delirium.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Immunology
Allison M. Owen, Liming Luan, Katherine R. R. Burelbach, Margaret A. A. McBride, Cody L. L. Stothers, Olivia A. A. Boykin, Kalkena Sivanesam, Jessica F. F. Schaedel, Tazeen K. K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. K. Patil, Edward R. R. Sherwood, Julia K. K. Bohannon
Summary: Immunocompromised populations are at high risk of life-threatening infections, and strategies to protect these patients are urgently needed. This study explores the use of trained immunity, which enhances the immune response to subsequent infections, as a promising approach. The researchers demonstrate that the MyD88-dependent signaling pathway plays a critical role in TLR-mediated trained immunity, providing valuable insights into the mechanisms underlying this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Antonio Hernandez, Naeem K. Patil, Maya Brewer, Rachel Delgado, Lauren Himmel, Lauren N. Lopez, Julia K. Bohannon, Allison M. Owen, Edward R. Sherwood, Mark P. de Caestecker
Summary: This study aimed to investigate whether a novel Toll-like receptor 4 agonist could attenuate acute kidney injury induced by ischemia-reperfusion injury. The results showed that pretreatment with the agonist improved kidney function, reduced renal tissue injury and apoptosis. The findings suggest that the agonist can provide protection against ischemia-reperfusion injury-induced acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)