Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model

T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword

(2021) Elisavet Vlachonikola et al.   Frontiers in Immunology

Novel Agents in Chronic Lymphocytic Leukemia: New Combination Therapies and Strategies to Overcome Resistance

(2021) Moritz Fürstenau et al.   Cancers

B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making

(2020) Katerina Gemenetzi et al.   Frontiers in Oncology

hERG K+ Channels Promote Survival of Irradiated Leukemia Cells

(2020) Daniela Palme et al.   Frontiers in Pharmacology

Oxidation Impacts the Intracellular Signaling Machinery in Hematological Disorders

(2020) Elena Tibaldi et al.   Antioxidants

The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA

(2020) Alina Muenchow et al.   Cell Death & Disease

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

(2020) Roberta Peruzzo et al.   Redox Biology

Proliferative Signals in Chronic Lymphocytic Leukemia; What Are We Missing?

(2020) Marco V. Haselager et al.   Frontiers in Oncology

Targeting mitochondrial ion channels for cancer therapy

(2020) Ildiko Szabo et al.   Redox Biology

p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape

(2019) Laura Patrussi et al.   HAEMATOLOGICA

HSP70/HSF1 axis, regulated via a PI3K/AKT pathway, is a druggable target in chronic lymphocytic leukemia

(2019) Federica Frezzato et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

(2019) Xufeng Chen et al.   Cancer Discovery

STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia

(2019) Marjolaine Debant et al.   Journal for ImmunoTherapy of Cancer

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

(2019) Roberto Costa et al.   Cell Reports

Targeting mitochondria as an anticancer strategy

(2019) Lanfeng Dong et al.   Cancer Communications

In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment

(2019) Severin et al.   Cancers

iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL

(2018) Michael Hallek et al.   BLOOD

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

(2018) Gang Xiao et al.   CELL

Epigenetic deregulation in chronic lymphocytic leukemia: Clinical and biological impact

(2018) Larry Mansouri et al.   SEMINARS IN CANCER BIOLOGY

Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes

(2018) Gabriela Galicia-Vázquez et al.   Frontiers in Oncology

Chronic lymphocytic leukemia treatment algorithm 2018

(2018) Sameer A. Parikh   Blood Cancer Journal

Pharmacodynamics and proteomic analysis of acalabrutinib therapy: similarity of on-target effects to ibrutinib and rationale for combination therapy

(2017) V K Patel et al.   LEUKEMIA

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells

(2017) Elisa Venturini et al.   NEUROSIGNALS

Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

(2017) Daniel Bauer et al.   Cell Death & Disease

Pharmacological targeting of ion channels for cancer therapy: In vivo evidences

(2016) Luigi Leanza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia

(2016) Nisar A. Amin et al.   CLINICAL CANCER RESEARCH

Impact of intracellular ion channels on cancer development and progression

(2016) Roberta Peruzzo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

p53-independent ibrutinib responses in an Eμ-TCL1 mouse model demonstrates efficacy in high-risk CLL

(2016) H J Lee et al.   Blood Cancer Journal

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment

(2016) Giuseppina D'Alessandro et al.   Oncotarget

Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death

(2016) Erica Salaro et al.   Scientific Reports

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Ion channel expression as promising cancer biomarker

(2015) Elena Lastraioli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biophysical Characterization and Expression Analysis of Kv1.3 Potassium Channel in Primary Human Leukemic B Cells

(2015) Ildiko Szabo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel perspectives in cancer therapy: Targeting ion channels

(2015) Annarosa Arcangeli et al.   DRUG RESISTANCE UPDATES

BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia

(2015) S-S Chen et al.   LEUKEMIA

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival

(2015) Valentina Trimarco et al.   Oncotarget

Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia

(2014) W. Fiskus et al.   CANCER RESEARCH

Targeting potassium channels in cancer

(2014) Xi Huang et al.   JOURNAL OF CELL BIOLOGY

Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade

(2014) E M Grössinger et al.   LEUKEMIA

Differential expression of hERG1A and hERG1B genes in pediatric acute lymphoblastic leukemia identifies different prognostic subgroups

(2014) S Pillozzi et al.   LEUKEMIA

Potassium channels in cell cycle and cell proliferation

(2014) D. Urrego et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial Channels: Ion Fluxes and More

(2014) Ildiko Szabo et al.   PHYSIOLOGICAL REVIEWS

Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells

(2014) Elayne Hondares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

(2013) I Azimi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia

(2013) L Leanza et al.   LEUKEMIA

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies

(2013) Jan A. Burger et al.   SEMINARS IN CANCER BIOLOGY

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

(2013) T Prezma et al.   Cell Death & Disease

The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer

(2013) Núria Comes et al.   Frontiers in Physiology

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium Channels

(2012) L. Leanza et al.   CURRENT MEDICINAL CHEMISTRY

Targeting Ion Channels in Leukemias: A New Challenge for Treatment

(2012) A. Arcangeli et al.   CURRENT MEDICINAL CHEMISTRY

Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia

(2012) M Sivina et al.   LEUKEMIA

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

The KCa3.1 Blocker TRAM-34 Reduces Infarction and Neurological Deficit in a Rat Model of Ischemia/Reperfusion Stroke

(2011) Yi-Je Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HS1 has a central role in the trafficking and homing of leukemic B cells

(2010) C. Scielzo et al.   BLOOD

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

(2009) David M. Lucas et al.   BLOOD

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

Targeting Ion Channels in Cancer: A Novel Frontier in Antineoplastic Therapy

(2008) A. Arcangeli et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA