Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker

(2013) Byung J. Kim et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Overview

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

(2013) Bilel Jelassi et al.   CARCINOGENESIS

ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells

(2012) Malika Faouzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methylation of the calcium channel regulatory subunit α2δ-3 (CACNA2D3) predicts site-specific relapse in oestrogen receptor-positive primary breast carcinomas

(2012) C Palmieri et al.   BRITISH JOURNAL OF CANCER

The role of transient receptor potential channel blockers in human gastric cancer cell viability

(2012) Byung Joo Kim et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

TRPM7 Is Required for Breast Tumor Cell Metastasis

(2012) Jeroen Middelbeek et al.   CANCER RESEARCH

Direct Therapeutic Applications of Calcium Electroporation to Effectively Induce Tumor Necrosis

(2012) S. K. Frandsen et al.   CANCER RESEARCH

Regulation of calcium influx and signaling pathway in cancer cells via TRPV6–Numb1 interaction

(2012) Sung-Young Kim et al.   CELL CALCIUM

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

TRPM7: A unique channel involved in magnesium homeostasis

(2012) Tamara M. Paravicini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Calcium Channels and Pumps in Cancer: Changes and Consequences

(2012) Gregory R. Monteith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human ether à-gogo K+ channel 1 (hEag1) regulates MDA-MB-231 breast cancer cell migration through Orai1-dependent calcium entry

(2012) Mehdi Hammadi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of the TRPV6 channel in cancer

(2012) V’yacheslav Lehen’kyi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium Channel TRPV6 as a Potential Therapeutic Target in Estrogen Receptor-Negative Breast Cancer

(2012) A. A. Peters et al.   MOLECULAR CANCER THERAPEUTICS

Intercellular Ca2+ Waves: Mechanisms and Function

(2012) Luc Leybaert et al.   PHYSIOLOGICAL REVIEWS

Non-Stimulated, Agonist-Stimulated and Store-Operated Ca2+ Influx in MDA-MB-468 Breast Cancer Cells and the Effect of EGF-Induced EMT on Calcium Entry

(2012) Felicity M. Davis et al.   PLoS One

TRPM8 Ion Channels Differentially Modulate Proliferation and Cell Cycle Distribution of Normal and Cancer Prostate Cells

(2012) María Ll. Valero et al.   PLoS One

Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line

(2012) Marina Petersen Gehring et al.   Purinergic Signalling

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

TRP channels: diagnostic markers and therapeutic targets for breast cancer?

(2012) Halima Ouadid-Ahidouch et al.   TRENDS IN MOLECULAR MEDICINE

Ion channels and transporters in cancer. 4. Remodeling of Ca2+ signaling in tumorigenesis: role of Ca2+ transport

(2011) Jane M. Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells

(2011) Jiajia Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium signalling in T-lymphocytes

(2011) V. Robert et al.   BIOCHIMIE

Voltage-gated calcium channels and disease

(2011) Stuart M. Cain et al.   BIOFACTORS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

High Expression of Transient Receptor Potential Channels in Human Breast Cancer Epithelial Cells and Tissues: Correlation with Pathological Parameters

(2011) Isabelle Dhennin-Duthille et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress

(2011) S-W Ip et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

(2011) Susanna Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

(2011) D. McAndrew et al.   MOLECULAR CANCER THERAPEUTICS

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

The Physiological Function of Store-operated Calcium Entry

(2011) James W. Putney   NEUROCHEMICAL RESEARCH

TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

(2011) A Fiorio Pla et al.   ONCOGENE

P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

(2011) B Jelassi et al.   ONCOGENE

Remodeling of Purinergic Receptor-Mediated Ca2+ Signaling as a Consequence of EGF-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells

(2011) Felicity M. Davis et al.   PLoS One

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

(2011) Wendy M. Knowlton et al.   PLoS One

Store-Operated Calcium Channels: New Perspectives on Mechanism and Function

(2011) R. S. Lewis   Cold Spring Harbor Perspectives in Biology

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells

(2010) Andrew W. Farrell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Estrogen regulation of TRPM8 expression in breast cancer cells

(2010) Dechen Chodon et al.   BMC CANCER

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231

(2010) Desma M. Grice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

(2010) Malika Faouzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

(2010) Daniel J. Parks et al.   JOURNAL OF MEDICINAL CHEMISTRY

ORAI-mediated calcium entry: Mechanism and roles, diseases and pharmacology

(2010) Sarah J. Roberts-Thomson et al.   PHARMACOLOGY & THERAPEUTICS

PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer

(2010) J. VanHouten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Cancer in Developing Countries: Opportunities for Improved Survival

(2010) Lawrence N. Shulman et al.   Journal of Oncology

Evidence that TRPM7 is required for breast cancer cell proliferation

(2009) Arnaud Guilbert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of TRPC6 channels in human epithelial breast cancer cells

(2009) Arnaud Guilbert et al.   BMC CANCER

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy

(2009) Ebru Aydar et al.   Cancer Cell International

MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?

(2009) Ann F. Chambers   CANCER RESEARCH

Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner

(2009) C. Amantini et al.   CARCINOGENESIS

Extracellular Signal-Regulated Kinases 1 and 2 and TRPC1 Channels are Required for Calcium-Sensing Receptor-Stimulated MCF-7 Breast Cancer Cell Proliferation

(2009) Yassine El Hiani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration

(2009) Emad Afrasiabi et al.   CELLULAR SIGNALLING

Introducing Molecular Subtyping of Breast Cancer Into the Clinic?

(2009) Therese Sørlie   JOURNAL OF CLINICAL ONCOLOGY

Transient receptor potential channel C3 contributes to the progression of human ovarian cancer

(2009) S L Yang et al.   ONCOGENE

The progesterone receptor regulates the expression of TRPV4 channel

(2009) Carole Jung et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

(2009) S. Kiyonaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM and Orai: the long-awaited constituents of store-operated calcium entry

(2009) Péter Várnai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

Localization of plasma membrane and secretory calcium pumps in the mammary gland

(2008) Helen M. Faddy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis

(2008) Ingrid M. Overes et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation

(2008) James T. Taylor et al.   CANCER LETTERS

Triple-Negative Breast Cancer: Risk Factors to Potential Targets

(2008) B. P. Schneider et al.   CLINICAL CANCER RESEARCH

Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

(2008) Arthur Gomtsyan et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of TRPV6 in breast carcinogenesis

(2008) K. A. Bolanz et al.   MOLECULAR CANCER THERAPEUTICS

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors

(2008) Diana L. Donnelly-Roberts et al.   NEUROPHARMACOLOGY

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON