Identifying the mechanism underlying antidepressant-like effects of loganin by network pharmacology in combination with experimental validation

A network pharmacology approach to explore the potential targets underlying the effect of sinomenine on rheumatoid arthritis

(2020) Xiang Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Atractylodes macrocephala Koidz. for the Treatment of Chronic Gastritis

(2020) Songhong Yang et al.   Frontiers in Pharmacology

The cytokine network in the pathogenesis of major depressive disorder. Close to translation?

(2020) Maria Cristina Petralia et al.   AUTOIMMUNITY REVIEWS

Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway

(2020) Jiahui Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway

(2020) Xinqi Zhuang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

(2020) Eléonore Beurel et al.   NEURON

Connexin 43: A novel ginsenoside Rg1-sensitive target in a rat model of depression

(2020) Cong-Yuan Xia et al.   NEUROPHARMACOLOGY

Effects of lithium on cytokine neuro-inflammatory mediators, Wnt/β-catenin signaling and microglial activation in the hippocampus of chronic mild stress-exposed rats

(2020) Mohamed Z. Habib et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

(2020) Poonam Sarode et al.   Science Advances

Microglia: A Central Player in Depression

(2020) Si-long Deng et al.   Current Medical Science

Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade

(2019) Wenqi Gao et al.   METABOLIC BRAIN DISEASE

IL-10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF-κB/Notch1 pathway in non-small cell lung cancer

(2019) Li Yang et al.   INTERNATIONAL JOURNAL OF CANCER

CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4

(2019) Chen Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Effects of Liuwei Dihuang Decoction (Yukmijihwang-tang) on Physical Fatigue by Regulating Neurotransmitters in Brain

(2019) Ji-Ye Kee et al.   Chinese Journal of Integrative Medicine

The Modulation of Regulatory T Cells via HMGB1/PTEN/β-Catenin Axis in LPS Induced Acute Lung Injury

(2019) Min Zhou et al.   Frontiers in Immunology

Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/β-catenin signaling pathway

(2019) Yue-yi Yao et al.   BRAIN RESEARCH

WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment

(2019) Xin Li et al.   Frontiers in Immunology

Identification of Potential Crucial Genes and Key Pathways in Breast Cancer Using Bioinformatic Analysis

(2019) Jun-Li Deng et al.   Frontiers in Genetics

DNA methylation exploration for ARDS: a multi-omics and multi-microarray interrelated analysis

(2019) Shi Zhang et al.   Journal of Translational Medicine

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

(2019) Björn Laffer et al.   Frontiers in Cellular Neuroscience

A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza

(2019) Shuna Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes

(2019) Jiaming Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Loganin alleviates LPS‐activated intestinal epithelial inflammation by regulating TLR4/NF‐κB and JAK/STAT3 signaling pathways

(2019) Jia‐Wen Wang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling

(2019) Dongqiang Yang et al.   MOLECULAR IMMUNOLOGY

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination

(2019) Li-Wen Chu et al.   PHYTOMEDICINE

sFRP2 promotes airway inflammation and Th17/Treg imbalance in COPD via Wnt/β-catenin pathway

(2019) Miao Zhou et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Th17 cells in depression

(2018) Eléonore Beurel et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures

(2018) Joanna Ślusarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc

(2018) Jun Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Fengna Chu et al.   JOURNAL OF NEUROIMMUNOLOGY

Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation

(2018) Rebeca Vidal et al.   MOLECULAR NEUROBIOLOGY

Alpha-1 Antitrypsin Attenuates M1 Microglia-Mediated Neuroinflammation in Retinal Degeneration

(2018) Tian Zhou et al.   Frontiers in Immunology

Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats

(2018) M Rajabi et al.   Physiology International

Rapid inflammation modulation and antidepressant efficacy of a low-dose ketamine infusion in treatment-resistant depression: A randomized, double-blind control study

(2018) Mu-Hong Chen et al.   PSYCHIATRY RESEARCH

Loganin prevents BV-2 microglia cells from Aβ1-42 -induced inflammation via regulating TLR4/TRAF6/NF-κB axis

(2018) Yong Cui et al.   CELL BIOLOGY INTERNATIONAL

Suppression of TLR 4 by miR‐448 is involved in Diabetic development via regulating Macrophage polarization

(2018) Qing Zhao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity

(2018) Tomokazu Sumida et al.   NATURE IMMUNOLOGY

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

(2018) Lijuan Zhang et al.   Frontiers in Cellular Neuroscience

Cornusides A–O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis

(2017) Xian-Sheng Ye et al.   JOURNAL OF NATURAL PRODUCTS

ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin-C via Wnt/β-catenin pathway

(2017) Hao Sha et al.   Molecular Medicine Reports

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

(2017) Xia Wang et al.   NUCLEIC ACIDS RESEARCH

Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNF-α

(2017) Gao Chao et al.   PLoS One

Effects of Antidepressants on Sleep

(2017) Adam Wichniak et al.   Current Psychiatry Reports

LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974

(2017) Jaewoong Jang et al.   Scientific Reports

Disease-Induced Neuroinflammation and Depression

(2016) Cristina Benatti et al.   CNS & Neurological Disorders-Drug Targets

Loganin inhibits the inflammatory response in mouse 3T3L1 adipocytes and mouse model

(2016) Yang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

The interface of depression and cardiovascular disease: therapeutic implications

(2015) Fred Seligman et al.   Annals of the New York Academy of Sciences

Depression in Type 2 Diabetes Mellitus: Prevalence, Impact, and Treatment

(2015) Katherine Semenkovich et al.   DRUGS

Loganin protects against pancreatitis by inhibiting NF-κB activation

(2015) Myoung-Jin Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

(2015) M.S. Moehle et al.   NEUROSCIENCE

β-catenin regulates NF-κB activity and inflammatory cytokine expression in bronchial epithelial cells treated with lipopolysaccharide

(2014) JAEWOONG JANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation

(2014) Indumathi Manoharan et al.   JOURNAL OF IMMUNOLOGY

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

The effect of citalopram on chronic stress-induced depressive-like behavior in rats through GSK3β/β-catenin activation in the medial prefrontal cortex

(2012) Y.C. Chen et al.   BRAIN RESEARCH BULLETIN

WNT/β-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line

(2011) Haeyong Lee et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice

(2010) Noriko Yamabe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE