Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade

Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway

(2018) Wenqi Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice

(2018) Yosuke Yamawaki et al.   BRAIN RESEARCH

miR-214-3p Targets β-Catenin to Regulate Depressive-like Behaviors Induced by Chronic Social Defeat Stress in Mice

(2018) Zhi-Fang Deng et al.   CEREBRAL CORTEX

Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients

(2017) Ni Fan et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway

(2017) Zhengmao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway

(2016) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)

(2016) Satoru Matsuda et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models

(2016) Germain Sotoing Taiwe et al.   JOURNAL OF ETHNOPHARMACOLOGY

Involvement of PI3K/Akt/GSK-3β and mTOR in the antidepressant-like effect of atorvastatin in mice

(2016) Fabiana Kalyne Ludka et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats

(2016) Kapil Suchal et al.   PHYTOMEDICINE

The administration of erythropoietin attenuates kidney injury induced by ischemia/reperfusion with increased activation of Wnt/β-catenin signaling

(2015) Xiao Chen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1

(2015) Julie Y.H. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Mortality in Mental Disorders and Global Disease Burden Implications

(2015) Elizabeth Reisinger Walker et al.   JAMA Psychiatry

Fluoxetine Regulates Neurogenesis In Vitro Through Modulation of GSK-3 / -Catenin Signaling

(2015) J. Hui et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

(2014) Ying Xu et al.   Current Neuropharmacology

Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease

(2014) Wei-wei Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

LPS-induced oxidative stress and inflammatory reaction in the rat striatum

(2014) Karolina Noworyta-Sokołowska et al.   Pharmacological Reports

What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression

(2014) Bradley N. Gaynes et al.   PSYCHIATRIC SERVICES

Oxidative/Nitrosative Stress in Psychiatric Disorders: Are We There Yet?

(2014) P. O'Donnell et al.   SCHIZOPHRENIA BULLETIN

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

(2013) Harvey A Whiteford et al.   LANCET

Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke

(2013) Lu Yu et al.   PLoS One

Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice

(2013) Shigeki Moriguchi et al.   PLoS One

Dysregulated relationship of inflammation and oxidative stress in major depression

(2012) B.J. Rawdin et al.   BRAIN BEHAVIOR AND IMMUNITY

The effect of citalopram on chronic stress-induced depressive-like behavior in rats through GSK3β/β-catenin activation in the medial prefrontal cortex

(2012) Y.C. Chen et al.   BRAIN RESEARCH BULLETIN

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

(2012) Adrian L Lopresti et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Mild Depressive Symptoms Are Associated with Elevated C-Reactive Protein and Proinflammatory Cytokine Levels During Early to Midgestation: A Prospective Pilot Study

(2012) Rima Azar et al.   JOURNAL OF WOMENS HEALTH

Antioxidants as potential therapeutics for neuropsychiatric disorders

(2012) Chirayu D. Pandya et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

(2012) S J Sukoff Rizzo et al.   Translational Psychiatry

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Alterations in Phosphatidylinositol 3-Kinase Activity and PTEN Phosphatase in the Prefrontal Cortex of Depressed Suicide Victims

(2011) Félicien Karege et al.   NEUROPSYCHOBIOLOGY

Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer

(2010) Tracy M. Covey et al.   PLoS One

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid

(2009) Ricardo Lagoa et al.   JOURNAL OF NEUROCHEMISTRY

Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg

(2008) Sung Kyu Kim et al.   ARCHIVES OF PHARMACAL RESEARCH