Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Lipin-2 regulates NLRP3 inflammasome by affecting P2X 7 receptor activation

(2016) Gema Lordén et al.   JOURNAL OF EXPERIMENTAL MEDICINE

"Shping 2" different cellular localizations - a potential new player in aging processes

(2016) Sascha Jakob et al.   Aging-US

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

(2015) Zihou Deng et al.   NATURE IMMUNOLOGY

Neuroinflammation: Targeting neuroinflammation through inhibition of NLRP3

(2015) Alex Chase   Nature Reviews Neurology

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin

(2013) Wen-Jie Guo et al.   Autophagy

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

The mitochondrial ADP/ATP carrier (SLC25 family): Pathological implications of its dysfunction

(2013) Benjamin Clémençon et al.   MOLECULAR ASPECTS OF MEDICINE

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature

(2012) A. D. R. Serra-Nedelec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

(2012) Shuangwei Li et al.   Frontiers of Medicine

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Mitochondrial protein import: from transport pathways to an integrated network

(2011) Thomas Becker et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria

(2009) Jianhua Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function

(2008) Jianhua Feng et al.   CARDIOVASCULAR RESEARCH

Localization of PTP-1B, SHP-2, and Src Exclusively in Rat Brain Mitochondria and Functional Consequences

(2008) Amal Arachiche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY