Kirenol: A promising bioactive metabolite from siegesbeckia species: A detailed review

Protective Effects of Kirenol against Lipopolysaccharide-Induced Acute Lung Injury through the Modulation of the Proinflammatory NFκB Pathway and the AMPK2-/Nrf2-Mediated HO-1/AOE Pathway

(2021) Frank Cheau-Feng Lin et al.   Antioxidants

Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways

(2021) Abdullah M. Alzahrani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatoprotective potential of kirenol on ethanol‐induced liver toxicity in albino rats and acetaminophen‐induced oxidative stress‐mediated apoptosis in hepatic HepG2 cells

(2021) Dongsheng Sun et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Antioxidant Compounds, Kirenol and Methyl ent-16α, 17-dihydroxy-kauran-19-oate Bioactivity-Guided Isolated from Siegesbeckia glabrescens Attenuates MITF-Mediated Melanogenesis via Inhibition of Intracellular ROS Production

(2021) Sun-Yup Shim et al.   MOLECULES

Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway

(2021) Peramaiyan Rajendran et al.   Oxidative Medicine and Cellular Longevity

Effect of kirenol on the interaction between the WNT/β-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivo

(2020) Ibrahim Karaman et al.   Acta Orthopaedica et Traumatologica Turcica

Botany, traditional use, phytochemistry, pharmacology and toxicology of Sigesbeckiae Herba (Xixiancao): a review

(2020) Hong Xun Tao et al.   PHYTOCHEMISTRY REVIEWS

Anti-inflammatory and wound healing potential of kirenol in diabetic rats through the suppression of inflammatory markers and matrix metalloproteinase expressions

(2020) Jia Ren et al.   BIOMEDICINE & PHARMACOTHERAPY

Kirenol inhibits RANKL-induced osteoclastogenesis and prevents ovariectomized-induced osteoporosis via suppressing the Ca2+-NFATc1 and Cav-1 signaling pathways

(2020) Binhua Zou et al.   PHYTOMEDICINE

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

(2020) Yihan Yao et al.   Frontiers in Molecular Biosciences

Kirenol inhibited the cell survival and induced apoptosis in human thyroid cancer cells by altering PI3K / AKT and MAP kinase signaling pathways

(2020) Yulong Wang et al.   ENVIRONMENTAL TOXICOLOGY

Alternative therapy of rheumatoid arthritis with a novel transdermal patch containing Siegesbeckiae Herba extract

(2020) Peng Quan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration

(2020) Yu-Sang Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-tumour effects of red blood cell membrane-camouflaged black phosphorous quantum dots combined with chemotherapy and anti-inflammatory therapy

(2019) Xueyuan Huang et al.   Artificial Cells Nanomedicine and Biotechnology

Semisynthesis of epoxy-pimarane diterpenoids from kirenol and their FXa inhibition activities

(2019) Jianbin Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo

(2019) Jing Wu et al.   Frontiers in Immunology

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

(2019) Lidija Milkovic et al.   Cells

Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model

(2019) Bin Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations

(2019) Zhangfeng Zhong et al.   Chinese Medicine

Standardized Siegesbeckia orientalis L. Extract Increases Exercise Endurance Through Stimulation of Mitochondrial Biogenesis

(2019) Mi-Bo Kim et al.   JOURNAL OF MEDICINAL FOOD

Comprehensive comparison on the anti-inflammatory effects of three species of Sigesbeckia plants based on NF-κB and MAPKs signal pathways in vitro

(2019) Ke-Gang Linghu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fast simultaneous detection of three diterpenoids in Herba Siegesbeckiae using solid phase extraction followed by HPLC-UV with a core–shell particle column

(2018) Yong Zhang et al.   Analytical Methods

Semisynthesis of ent -norstrobane diterpenoids as potential inhibitor for factor Xa

(2018) Jianbin Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nitric oxide inhibitory constituents from Siegesbeckia pubescens

(2018) Hari Jang et al.   BIOORGANIC CHEMISTRY

Comparison of the chemical profiles and inflammatory mediator-inhibitory effects of three Siegesbeckia herbs used as Herba Siegesbeckiae (Xixiancao)

(2018) Hui Guo et al.   BMC Complementary and Alternative Medicine

Implications of Underlying Mechanisms for the Recognition and Management of Diabetic Cardiomyopathy

(2018) Thomas H. Marwick et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An ethanolic extract of the aerial part of Siegesbeckia orientalis L. inhibits the production of inflammatory mediators regulated by AP-1, NF-κB and IRF3 in LPS-stimulated RAW 264.7 cells

(2018) Hui Guo et al.   BioScience Trends

Techniques for extraction and isolation of natural products: a comprehensive review

(2018) Qing-Wen Zhang et al.   Chinese Medicine

Siegesbeckia pubescens Makino inhibits Pam3CSK4-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation

(2018) Wei Sang et al.   Chinese Medicine

Pimarane diterpenes: Natural source, stereochemical configuration, and biological activity

(2018) Pierluigi Reveglia et al.   CHIRALITY

Protective Effects of Standardized Siegesbeckia glabrescens Extract and Its Active Compound Kirenol against UVB-Induced Photoaging through Inhibition of MAPK/NF-��B Pathways

(2017) Jongwook Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway

(2016) Sevil Korkmaz-Icöz et al.   Cardiovascular Diabetology

Siegesbeckia pubescens Attenuates Iodoacetamide-induced Colitis in Rats

(2016) Yi-ping Ye et al.   International Journal of Pharmacology

ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

(2016) Jianbin Wang et al.   JOURNAL OF NATURAL PRODUCTS

Fungal phytotoxins with potential herbicidal activity: chemical and biological characterization

(2015) Alessio Cimmino et al.   NATURAL PRODUCT REPORTS

Kirenol Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Differentiation of Th1 and Th17 Cells and Inducing Apoptosis of Effector T Cells

(2015) Juan Xiao et al.   Scientific Reports

Kirenol inhibits adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes

(2014) Mi-Bo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ent-Kaurane and ent-Pimarane Diterpenes from Siegesbeckia pubescens Inhibit Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia

(2014) Mina Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Kirenol stimulates osteoblast differentiation through activation of the BMP and Wnt/β-catenin signaling pathways in MC3T3-E1 cells

(2014) Mi-Bo Kim et al.   FITOTERAPIA

Optimization of high hydrostatic pressure process for the extraction of kirenol from Siegesbeckia orientalis L. using response surface methodology

(2014) Mi-Bo Kim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Fungal metabolites with anticancer activity

(2014) Antonio Evidente et al.   NATURAL PRODUCT REPORTS

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

Simultaneous quantification of Kirenol and ent-16β,17-dihydroxy-kauran-19-oic acid from Herba Siegesbeckiae in rat plasma by liquid chromatography–tandem mass spectrometry and its application to pharmacokinetic studies

(2013) Linan Huo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Simultaneous determination of seven major diterpenoids inSiegesbeckia pubescensMakino by high-performance liquid chromatography coupled with evaporative light scattering detection

(2012) Linan Huo et al.   JOURNAL OF SEPARATION SCIENCE

Kefir inhibits 3T3-L1 adipocyte differentiation through down-regulation of adipogenic transcription factor expression

(2012) Jin-Nyoung Ho et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Kirenol production in hairy root culture of Siegesbeckea orientalis and its antimicrobial activity

(2012) Yong-Hui Zhang et al.   Pharmacognosy Magazine

Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cells balance

(2012) Yue Lu et al.   PHYTOMEDICINE

Molecularly imprinted polymer for the specific solid-phase extraction of kirenol from Siegesbeckia pubescens herbal extract

(2012) Fang-Fang Chen et al.   TALANTA

Effects of amla extract and collagen peptide on UVB-induced photoaging in hairless mice

(2012) Takashi Fujii et al.   Journal of Functional Foods

Enrichment of (E)-Resveratrol from Peanut Byproduct with Molecularly Imprinted Polymers

(2011) Lachlan J. Schwarz et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kirenol upregulates nuclear Annexin-1 which interacts with NF-κB to attenuate synovial inflammation of collagen-induced arthritis in rats

(2011) Zhe-Ming Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis

(2011) Jian-ping Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Simultaneous quantification of eight major constituents in Herba Siegesbeckiae by liquid chromatography coupled with electrospray ionization time-of-flight tandem mass spectrometry

(2011) Zhen Jiang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Synthesis and study of a molecularly imprinted polymer for the specific extraction of indole alkaloids from Catharanthus roseus extracts

(2010) C. Lopez et al.   ANALYTICA CHIMICA ACTA

A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study

(2010) Xiao-Li Song et al.   BIOMEDICAL CHROMATOGRAPHY

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

ent-Kaurane andent-Pimarane Diterpenoids fromSiegesbeckia pubescens

(2009) Rui Wang et al.   JOURNAL OF NATURAL PRODUCTS

Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

(2008) Tuulikki Sokka et al.   ARTHRITIS AND RHEUMATISM

RV09, a novel resveratrol analogue, inhibits NO and TNF-α production by LPS-activated microglia

(2008) Xue Lian Meng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synthesis of caffeic acid and p-hydroxybenzoic acid molecularly imprinted polymers and their application for the selective extraction of polyphenols from olive mill waste waters

(2008) Chrysa Michailof et al.   JOURNAL OF CHROMATOGRAPHY A

A rush to judgment on Th17: Figure 1.

(2008) Lawrence Steinman   JOURNAL OF EXPERIMENTAL MEDICINE

A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis

(2008) Howard L. Weiner   JOURNAL OF NEUROLOGY