Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ly Thi Huong Nguyen, Sang-Hyun Ahn, Min-Jin Choi, In-Jun Yang, Heung-Mook Shin
Summary: Puerarin has been shown to promote wound healing by accelerating wound closure rate, increasing keratinocyte proliferation and migration, and enhancing capillary density and collagen fiber levels at the wound sites. Additionally, it activates the ERK and Akt signaling pathways to facilitate keratinocyte function. These findings suggest that puerarin could be a potential treatment for delayed and impaired wound healing caused by dexamethasone.
APPLIED SCIENCES-BASEL
(2021)
Article
Biotechnology & Applied Microbiology
Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang
Summary: IGF2BP2 plays a crucial role in wound healing by regulating proliferation, migration, and angiogenesis of keratinocytes. Knockdown of IGF2BP2 inhibits these processes in keratinocytes by decreasing the stability of HPSE.
Article
Dermatology
Shen Yan, Raphael Ripamonti, Hiroshi Kawabe, Maya Ben-Yehuda Greenwald, Sabine Werner
Summary: The ubiquitin ligase NEDD4-1 plays crucial roles in various aspects of skin function, including keratinocyte proliferation, differentiation, and wound repair. Lack of NEDD4-1 in keratinocytes leads to impaired migration and proliferation, resulting in delayed re-epithelialization of wounds. This study highlights the importance of NEDD4-1 in skin homeostasis and identifies its involvement in mitogenic and motogenic signaling pathways.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pivian Sim, Yunmei Song, Gink N. Yang, Allison J. Cowin, Sanjay Garg
Summary: Strategies to alter wound pH for better healing outcomes are an emerging area of interest. This study investigated the effects of acidification on the metabolic activity and migration of skin cells. The results demonstrated a positive effect of acidic pH, suggesting its potential clinical application in wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Parasitology
Arkadi Kundik, Zaneta D. Musimbi, Juergen Kruecken, Thomas Hildebrandt, Oleg Kornilov, Susanne Hartmann, Friederike Ebner
Summary: The study optimized a fluorometric technique using resazurin for evaluating the metabolic activity of Ascaris suum third-stage larvae (L3) and found that both metabolic stressors and anthelmintic drugs significantly reduced the larval metabolic activity. This method is sensitive and easy-to-use for assessing the metabolic activity of A. suum L3 in vitro.
PARASITES & VECTORS
(2023)
Article
Cell Biology
Lei Qiang, Seungwon Yang, Yan-Hong Cui, Yu-Ying He
Summary: The study found that inhibiting epidermal cell autophagy impairs wound healing in mice, affecting processes such as keratinocyte proliferation, immune cell infiltration, and dermal tissue formation. TNF induces CCL2 transcription through the autophagy-AMPK-BRAF-MAPK1/3/ERK-AP1 pathway, influencing keratinocyte migration and proliferation, and activating dermal fibroblasts.
Article
Biochemistry & Molecular Biology
Apor Veres-Szekely, Domonkos Pap, Beata Szebeni, Laszlo Orfi, Csenge Szasz, Csenge Pajtok, Eszter Levai, Attila J. Szabo, Adam Vannay
Summary: Fibroblasts play a central role in diseases such as idiopathic pulmonary fibrosis. This study developed a cost-effective method to examine fibroblast migration and discussed the advantages of combining different functional assays in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Giulia Lombardo, Gloria Melzi, Serena Indino, Stefano Piazza, Enrico Sangiovanni, Franz Baruffaldi Preis, Laura Marabini, Elena Donetti
Summary: Pre-treatment with Vitis vinifera L. leaf extract (VVLe) can reverse UVB-induced cellular damage and modulate the early epidermal response in human skin. VVLe offers protection by regulating the expression of inducible keratin K17 and the epidermal distribution of Toll-Like Receptor (TLR) 4. However, the effectiveness of VVLe in countering radiation-induced genotoxicity remains unclear.
CELLS TISSUES ORGANS
(2022)
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Materials Science, Biomaterials
Oliver G. Frost, Nazanin Owji, Richard Thorogate, Christos Kyriakidis, Prasad Sawadkar, Nicola Mordan, Jonathan C. Knowles, Ferdinand Lali, Elena Garcia-Gareta
Summary: Cell morphology plays a crucial role in cell-biomaterial surface interactions, indicating ideal candidates for various applications and reducing screening and development time.
BIOMATERIALS SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Mary E. Stack, Sarita Mishra, Matangi Parimala Chelvi Ratnamani, Haoyu Wang, Leslie I. Gold, Hongjun Wang
Summary: This study incorporates Calreticulin (CRT) into polycaprolactone (PCL)/type 1 collagen (Col1) nanofibers to create biomimetic extracellular matrices for enhanced wound healing. The CRT nanofibers show sustained release of CRT and protection from proteolytic degradation. Additionally, the CRT nanofibers stimulate cell proliferation and migration, and offer customizable loading, protection, and sustained release of CRT.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Hsiao-Chi Lai, Chang-Shen Lin, Ching-Shuang Wu, Cheng-Che E. Lan
Summary: The study showed that low irradiance UVB induced significantly more aberrant epidermal proliferation via enhanced ROS and pAKT signaling compared to high irradiance UVB at equivalent fluence. Reducing UVB-induced AKT phosphorylation presents a novel strategy to improve the protective capacity of the currently available sunscreens.
Article
Cell Biology
Alireza Sohrabi, Austin E. Y. T. Lefebvre, Mollie J. Harrison, Michael C. Condro, Talia M. Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh, Harley I. Kornblum, Michelle A. Digman, Stephanie K. Seidlits
Summary: The mechanical properties of solid tumors play a crucial role in influencing tumor cell phenotype and invasive behavior. This study demonstrates that a soft, brain-like matrix can induce a metabolic shift in glioblastoma (GBM) cells towards glycolysis, leading to increased migration activities. These mechanical cues are transduced via CD44 and integrin receptors, resulting in metabolic and phenotypic changes in cancer cells.
Article
Entomology
Matthew Wolkoff, Lydia Fyie, Megan Meuti
Summary: The Northern house mosquito transmits West Nile virus and survives the winter through diapause. Light pollution has been found to interfere with diapause initiation in this mosquito. This study investigates the effects of light pollution on mosquito activity and metabolic products, indicating its potential disruption of nutrient accumulation and diapause initiation in this species.
Article
Biochemistry & Molecular Biology
Sanna Gudmundsson, Maria Wilbe, Sara Ekvall, Adam Ameur, Nicola Cahill, Ludmil B. Alexandrov, Marie Virtanen, Maritta Hellstrom Pigg, Anders Vahlquist, Hans Torma, Marie-Louise Bondeson
HUMAN MOLECULAR GENETICS
(2017)
Letter
Dermatology
A. Hotz, C. Fagerberg, A. Vahlquist, A. Bygum, H. Torma, M-A Rauschendorf, H. Zhang, L. Heinz, E. Bourrat, I. Hausser, V. Vestergaard, A. Dragomir, A. D. Zimmer, J. Fischer
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Article
Dermatology
Hanqian Zhang, Maja Ericsson, Marie Virtanen, Simone Westroem, Carolina Waehlby, Anders Vahlquist, Hans Torma
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Dermatology
H. Torma, A. Bergstrom, G. Ghiasifarahani, B. Berne
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2014)
Article
Dermatology
Hao Li, Anders Vahlquist, Hans Torma
JOURNAL OF DERMATOLOGICAL SCIENCE
(2013)
Article
Dermatology
T. Hoppe, M. C. G. Winge, M. Bradley, M. Nordenskjold, A. Vahlquist, H. Torma, B. Berne
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Olesya Krivospitskaya, Ali Ateia Elmabsout, Eva Sundman, Leif A. Soderstrom, Olga Ovchinnikova, Andreas C. Gidlof, Nikolai Scherbak, Giuseppe Danilo Norata, Ann Samnegard, Hans Torma, Samy M. Abdel-Halim, Jan-Hakan Jansson, Per Eriksson, Allan Sirsjo, Peder S. Olofsson
MOLECULAR MEDICINE
(2012)
Article
Multidisciplinary Sciences
Johanna Dahlqvist, Hans Torma, Jitendra Badhai, Niklas Dahl
Article
Multidisciplinary Sciences
Ali Ateia Elmabsout, Ashok Kumawat, Patricia Saenz-Mendez, Olesya Krivospitskaya, Helena Savenstrand, Peder S. Olofsson, Leif A. Eriksson, Ake Strid, Guro Valen, Hans Torma, Allan Sirsjo
Article
Dermatology
Hanqian Zhang, Maja Ericsson, Simone Westrom, Anders Vahiquist, Marie Virtanen, Hans Torma
EXPERIMENTAL DERMATOLOGY
(2019)
Editorial Material
Cell & Tissue Engineering
Nikola Kolundzic, Preeti Khurana, Carl Hobbs, Marija Rogar, Sandra Ropret, Hans Torma, Dusko Ilic, Mirjana Liovic
STEM CELL RESEARCH
(2019)
Review
Dermatology
Anders Vahlquist, Hans Torma
ACTA DERMATO-VENEREOLOGICA
(2020)
Review
Dermatology
Anders Vahlquist, Judith Fischer, Hans Torma
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2018)
Article
Dermatology
Tina Zupancic, Gregor Sersa, Hans Torma, Ellen Birgitte Lane, Harald Herrmann, Radovan Komel, Mirjana Liovic
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2017)
Article
Dermatology
Hao Li, Hans Torma
ACTA DERMATO-VENEREOLOGICA
(2013)