PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding

Post-translational modifications of intermediate filament proteins: mechanisms and functions

(2014) Natasha T. Snider et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation

(2013) W. Wu et al.   HUMAN MOLECULAR GENETICS

Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains

(2012) Aibing Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nonmuscle myosin-2: mix and match

(2012) Sarah M. Heissler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Generic and Personalized RNAi-Based Therapeutics for a Dominant-Negative Epidermal Fragility Disorder

(2012) Deena M. Leslie Pedrioli et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nuclear lamin functions and disease

(2012) Veronika Butin-Israeli et al.   TRENDS IN GENETICS

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene

(2011) A. Muchir et al.   CARDIOVASCULAR RESEARCH

Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene

(2010) Wei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

FLT3 inhibition as a targeted therapy for acute myeloid leukemia

(2010) Miguel Sanz et al.   CURRENT OPINION IN ONCOLOGY

Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

(2010) Thomas Fischer et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia

(2010) Michelle Kerns et al.   MOLECULAR BIOLOGY OF THE CELL

Protein kinase inhibition of clinically important staurosporine analogues

(2010) Osman A. B. S. M. Gani et al.   NATURAL PRODUCT REPORTS

“IF-pathies”: a broad spectrum of intermediate filament–associated diseases

(2009) M. Bishr Omary   JOURNAL OF CLINICAL INVESTIGATION

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility

(2009) Pierre A. Coulombe et al.   JOURNAL OF CLINICAL INVESTIGATION

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation

(2008) G-Z Tao et al.   JOURNAL OF PATHOLOGY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL

The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases

(2007) Ildiko Szeverenyi et al.   HUMAN MUTATION