Genotype to Phenotype: CRISPR Gene Editing Reveals Genetic Compensation as a Mechanism for Phenotypic Disjunction of Morphants and Mutants

Transcriptional adaptation in Caenorhabditis elegans

(2020) Vahan Serobyan et al.   eLife

Frame-shifted proteins of a given gene retain the same function

(2020) Xin Huang et al.   NUCLEIC ACIDS RESEARCH

Premature Termination Codon-Bearing mRNA Mediates Genetic Compensation Response

(2020) Zhipeng Ma et al.   Zebrafish

Frameshifted proteins of a given gene are unlikely to retain the same function

(2020) Alexander S Mankin   RNA

Transcriptional adaptation: a mechanism underlying genetic robustness

(2020) Tamar E. Sztal et al.   DEVELOPMENT

The Critical Role of AtPAP17 and AtPAP26 Genes in Arabidopsis Phosphate Compensation Network

(2020) Siamak Farhadi et al.   Frontiers in Plant Science

UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond

(2019) Yoon Ki Kim et al.   RNA

Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing?

(2019) Alex M. Zimmer et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

(2019) Zhipeng Ma et al.   NATURE

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish

(2019) Jason K.H. Lai et al.   DEVELOPMENTAL BIOLOGY

Delay in development and behavioural abnormalities in the absence of p53 in zebrafish

(2019) Seham Elabd et al.   PLoS One

Genetic compensation by epob in pronephros development in epoa mutant zebrafish

(2019) Jianqing She et al.   CELL CYCLE

CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae

(2019) Matthew C Salanga et al.   TOXICOLOGICAL SCIENCES

Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression

(2018) Rosa L. Moreno et al.   PLoS One

Nonsense-Mediated mRNA Decay Begins Where Translation Ends

(2018) Evangelos D. Karousis et al.   Cold Spring Harbor Perspectives in Biology

Phenotypic characterization of SETD3 knockout Drosophila

(2018) Marcel Tiebe et al.   PLoS One

Short body length phenotype is compensated by the upregulation of nidogen family members in a deleterious nid1a mutation of zebrafish

(2017) Peipei Zhu et al.   Journal of Genetics and Genomics

Emerging and evolving concepts in gene essentiality

(2017) Giulia Rancati et al.   NATURE REVIEWS GENETICS

Power provides protection: Genetic robustness in yeast depends on the capacity to generate energy

(2017) Marcin Plech et al.   PLoS Genetics

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes

(2017) Elsie S. Place et al.   PLoS One

The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease

(2016) Piaopiao Chen et al.   GENOME RESEARCH

Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways

(2016) Martino Colombo et al.   RNA

Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward

(2016) Nathan D. Lawson   TRENDS IN CELL BIOLOGY

Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development

(2016) Dhananjay Chaturvedi et al.   G3-Genes Genomes Genetics

Making Sense of Anti-Sense Data

(2015) Didier Y.R. Stainier et al.   DEVELOPMENTAL CELL

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

(2015) Fatma O. Kok et al.   DEVELOPMENTAL CELL

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

Pervasive robustness in biological systems

(2015) Marie-Anne Félix et al.   NATURE REVIEWS GENETICS

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

50 years of Arabidopsis research: highlights and future directions

(2015) Nicholas J. Provart et al.   NEW PHYTOLOGIST

Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish

(2015) Andrea Pauli et al.   PLoS One

Auxin binding protein 1 (ABP1) is not required for either auxin signaling orArabidopsisdevelopment

(2015) Yangbin Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Editing Versus Morphants

(2015) Paul A. Morcos et al.   Zebrafish

Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function

(2015) Anna Payne-Tobin Jost et al.   ACS Synthetic Biology

Targeted gene disruption in Xenopus laevis using CRISPR/Cas9

(2015) Fengqin Wang et al.   Cell and Bioscience

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

(2014) Shinya Yamamoto et al.   CELL

Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis

(2014) X. Guo et al.   DEVELOPMENT

Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules

(2014) Xu Chen et al.   NATURE

The Serine-Threonine Protein Kinase PAK4 Is Dispensable in Zebrafish: Identification of a Morpholino-Generated Pseudophenotype

(2014) Sheran H. W. Law et al.   PLoS One

Role of Pregnane X Receptor and Aryl Hydrocarbon Receptor in Transcriptional Regulation of pxr, CYP2, and CYP3 Genes in Developing Zebrafish

(2014) Akira Kubota et al.   TOXICOLOGICAL SCIENCES

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Mouse genetic and phenotypic resources for human genetics

(2012) Paul N. Schofield et al.   HUMAN MUTATION

The formin FMNL3 is a cytoskeletal regulator of angiogenesis

(2012) C. Hetheridge et al.   JOURNAL OF CELL SCIENCE

Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency

(2012) N. Daude et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale mouse knockouts and phenotypes

(2012) Ramiro Ramírez-Solis et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Using mutants, knockdowns, and transgenesis to investigate gene function in Drosophila

(2012) Daniel St Johnston   Wiley Interdisciplinary Reviews-Developmental Biology

The use of RNAi technologies for gene knockdown in zebrafish

(2011) A. Kelly et al.   Briefings in Functional Genomics

Gene dispensability

(2011) Ryszard Korona   CURRENT OPINION IN BIOTECHNOLOGY

The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish

(2010) Daniel Epting et al.   CIRCULATION RESEARCH

Platelet-Derived Growth Factor Receptor β Is Critical for Zebrafish Intersegmental Vessel Formation

(2010) Katie M. Wiens et al.   PLoS One

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries

(2009) B. M. Hogan et al.   DEVELOPMENT

The prion or the related Shadoo protein is required for early mouse embryogenesis

(2009) Rachel Young et al.   FEBS LETTERS

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Conditional Repression of AUXIN BINDING PROTEIN1 Reveals That It Coordinates Cell Division and Cell Expansion during Postembryonic Shoot Development in Arabidopsis and Tobacco

(2008) N. Braun et al.   PLANT CELL