Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity

Development of a High-Throughput Assay to Identify Inhibitors of ENPP1

(2021) Meera Kumar et al.   SLAS Discovery

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

(2021) Elisa Matas-Rico et al.   Cell Reports

Extracellular metabolism of the enteric inhibitory neurotransmitter β‐nicotinamide adenine dinucleotide (β‐NAD) in the murine colon

(2020) Leonie Durnin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering

(2020) Paul R. Stabach et al.   CTS-Clinical and Translational Science

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Metastasis and immune evasion from extracellular cGAMP hydrolysis

(2020) Jun Li et al.   Cancer Discovery

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

(2019) Francesca R. Auciello et al.   Cancer Discovery

ENPP1 in the Regulation of Mineralization and Beyond

(2019) Fiona Roberts et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autotaxin and chronic inflammatory diseases

(2019) Christiana Magkrioti et al.   JOURNAL OF AUTOIMMUNITY

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase

(2019) Mohammed I. El-Gamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1

(2019) Kenneth I. Onyedibe et al.   MOLECULES

The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions

(2019) Fernando Salgado-Polo et al.   Cancers

Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis

(2018) Manuel Baader et al.   BRITISH JOURNAL OF PHARMACOLOGY

PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization

(2018) Alan J. Stewart et al.   FASEB JOURNAL

Structural basis for nucleotide recognition by the ectoenzyme CD203c

(2018) Alexei Gorelik et al.   FEBS Journal

Lysophosphatidic acid produced by Autotaxin acts as an allosteric modulator of its catalytic efficiency

(2018) Fernando Salgado-Polo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3)

(2018) Christoph Döhler et al.   Scientific Reports

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

(2018) Kazuki Kato et al.   Nature Communications

Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain

(2018) Christoph Döhler et al.   Acta Crystallographica Section F-Structural Biology Communications

A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5

(2017) Alexei Gorelik et al.   FEBS Journal

Hepatocyte autotaxin expression promotes liver fibrosis and cancer

(2017) Eleanna Kaffe et al.   HEPATOLOGY

Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition

(2017) Alexei Gorelik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Serum Autotaxin Levels with Liver Fibrosis in Patients with Chronic Hepatitis C

(2017) Tomoo Yamazaki et al.   Scientific Reports

Association of Cole disease with novel heterozygous mutations in the somatomedin-B domains of theENPP1gene: necessary, but not always sufficient

(2016) N.A. Schlipf et al.   BRITISH JOURNAL OF DERMATOLOGY

Substrate and Transition State Binding in Alkaline Phosphatase Analyzed by Computation of Oxygen Isotope Effects

(2016) Daniel Roston et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

(2016) Willem-Jan Keune et al.   Nature Communications

Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

(2016) Junko Morita et al.   Scientific Reports

The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells

(2015) Shih Han Tsai et al.   IMMUNITY

Lysophosphatidic Acid Signaling in the Nervous System

(2015) Yun C. Yung et al.   NEURON

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy

(2015) Ronald A. Albright et al.   Nature Communications

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Autotaxin: structure-function and signaling

(2014) Anastassis Perrakis et al.   JOURNAL OF LIPID RESEARCH

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp6

(2014) Junko Morita et al.   Acta Crystallographica Section F-Structural Biology Communications

Molecular Basis of Purinergic Signal Metabolism by Ectonucleotide Pyrophosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke

(2013) Ronald A. Albright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin in embryonic development

(2012) Wouter H. Moolenaar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans

(2012) Anna J. S. Houben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Dynamics Simulation of Autotaxin: Roles of the Nuclease-like Domain and the Glycan Modification

(2012) Michio Koyama et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Bovine Brain Myelin Glycerophosphocholine Choline Phosphodiesterase is an Alkaline Lysosphingomyelinase of the eNPP-Family, Regulated by Lysosomal Sorting

(2012) Linn Greiner-Tollersrud et al.   NEUROCHEMICAL RESEARCH

Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

(2012) K. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

(2012) Christian Gachet   Purinergic Signalling

Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification

(2012) Silvia Jansen et al.   STRUCTURE

A 3D view of autotaxin

(2012) Hiroshi Nishimasu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7

(2011) Abby L Parrill et al.   BMC BIOCHEMISTRY

Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells

(2011) Zachary Fulkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Npp1 promotes atherosclerosis in ApoE knockout mice

(2011) Yvonne Nitschke et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structural basis of substrate discrimination and integrin binding by autotaxin

(2011) Jens Hausmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

(2011) Hiroshi Nishimasu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population

(2010) Teng Zhao et al.   JOURNAL OF HUMAN GENETICS

Domain Interplay Mediated by an Essential Disulfide Linkage Is Critical for the Activity and Secretion of the Metastasis-promoting Enzyme Autotaxin

(2009) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis

(2009) Zehra Pamuklar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alignment of protein structures in the presence of domain motions

(2008) Roberto Mosca et al.   BMC BIOINFORMATICS

Lysophosphatidic acid (LPA) and its receptors

(2008) Kyoko Noguchi et al.   CURRENT OPINION IN PHARMACOLOGY

The Role of Membrane Glycoprotein Plasma Cell Antigen 1/Ectonucleotide Pyrophosphatase Phosphodiesterase 1 in the Pathogenesis of Insulin Resistance and Related Abnormalities

(2008) Ira D. Goldfine et al.   ENDOCRINE REVIEWS