Hepatocyte autotaxin expression promotes liver fibrosis and cancer

Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate

(2016) Xiaoyun Tang et al.   JOURNAL OF LIPID RESEARCH

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

(2016) Willem-Jan Keune et al.   Nature Communications

Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma

(2015) A. Mazzocca et al.   CANCER RESEARCH

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

(2015) Matthew G. K. Benesch et al.   JOURNAL OF LIPID RESEARCH

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer

(2015) Efrosini Barbayianni et al.   PROGRESS IN LIPID RESEARCH

Lysophosphatidic Acid Alters the Expression Profiles of Angiogenic Factors, Cytokines, and Chemokines in Mouse Liver Sinusoidal Endothelial Cells

(2015) Chia-Hung Chou et al.   PLoS One

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life

(2015) Aggeliki Katsifa et al.   PLoS One

Interaction of platelet-derived autotaxin with tumor integrin  V 3 controls metastasis of breast cancer cells to bone

(2014) R. Leblanc et al.   BLOOD

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

(2014) Nicolas Dupont et al.   CURRENT BIOLOGY

Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions

(2014) Matthew G.K. Benesch et al.   FEBS LETTERS

Lysophosphatidic acid as a lipid mediator with multiple biological actions

(2014) S. Aikawa et al.   JOURNAL OF BIOCHEMISTRY

Serum Autotaxin Is a Parameter for the Severity of Liver Cirrhosis and Overall Survival in Patients with Liver Cirrhosis – A Prospective Cohort Study

(2014) Thomas Pleli et al.   PLoS One

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis

(2013) Takeki Uehara et al.   TOXICOLOGICAL SCIENCES

Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis

(2012) Nikos Oikonomou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

(2012) Ioanna Sevastou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Autotaxin in liver fibrosis

(2012) Hitoshi Ikeda et al.   CLINICA CHIMICA ACTA

Lysophosphatidic Acid Activates Lipogenic Pathways andde NovoLipid Synthesis in Ovarian Cancer Cells

(2012) Abir Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p100 Deficiency Is Insufficient for Full Activation of the Alternative NF-κB Pathway: TNF Cooperates with p52-RelB in Target Gene Transcription

(2012) Agnes Lovas et al.   PLoS One

Hepatocellualar Carcinoma Serum Markers

(2012) Gaetano Bertino et al.   SEMINARS IN ONCOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Structural basis of substrate discrimination and integrin binding by autotaxin

(2011) Jens Hausmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage

(2011) Diana N. D'Ambrosio et al.   PLoS One

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

ATX expression and LPA signalling are vital for the development of the nervous system

(2010) Stella Fotopoulou et al.   DEVELOPMENTAL BIOLOGY

Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma

(2010) Jian-Min Wu et al.   Molecular Cancer

Autotaxin Signaling via Lysophosphatidic Acid Receptors Contributes to Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration

(2010) M. M. Ptaszynska et al.   MOLECULAR CANCER RESEARCH

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis

(2009) Zehra Pamuklar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fat diet, obesity and prostate disease: the ATX–LPA axis?

(2009) Prakash Kulkarni et al.   Nature Reviews Urology

Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells

(2008) Song Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS