Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis

Hepatocyte autotaxin expression promotes liver fibrosis and cancer

(2017) Eleanna Kaffe et al.   HEPATOLOGY

Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL

(2016) Fengyun Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature

(2016) Diana Castagna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for specific inhibition of Autotaxin by a DNA aptamer

(2016) Kazuki Kato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for specific inhibition of Autotaxin by a DNA aptamer

(2016) Kazuki Kato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

(2015) Samar H. Ibrahim et al.   DIGESTIVE DISEASES AND SCIENCES

New insights into the autotaxin/LPA axis in cancer development and metastasis

(2015) Raphaël Leblanc et al.   EXPERIMENTAL CELL RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox

(2015) Sabin Llona-Minguez et al.   PROGRESS IN LIPID RESEARCH

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer

(2015) Efrosini Barbayianni et al.   PROGRESS IN LIPID RESEARCH

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma

(2014) Mayuko Kondo et al.   CLINICA CHIMICA ACTA

Autotaxin: structure-function and signaling

(2014) Anastassis Perrakis et al.   JOURNAL OF LIPID RESEARCH

Serum Autotaxin Is a Parameter for the Severity of Liver Cirrhosis and Overall Survival in Patients with Liver Cirrhosis – A Prospective Cohort Study

(2014) Thomas Pleli et al.   PLoS One

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

(2013) Jason R. Clapper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

(2012) Ioanna Sevastou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

Autotaxin as a novel serum marker of liver fibrosis

(2011) Hayato Nakagawa et al.   CLINICA CHIMICA ACTA

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-Throughput Analysis of Sphingosine 1-Phosphate, Sphinganine 1-Phosphate, and Lysophosphatidic Acid in Plasma Samples by Liquid Chromatography-Tandem Mass Spectrometry

(2009) M. Scherer et al.   CLINICAL CHEMISTRY

Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells

(2008) Satish Kalari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling

(2008) Catelijne Stortelers et al.   BMC GENOMICS