Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes

Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multi-site cohort

(2020) Julia L.M. Dunn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The emerging roles of eosinophils in mucosal homeostasis

(2020) Kathleen Shah et al.   Mucosal Immunology

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

(2020) Jiarui Ding et al.   NATURE BIOTECHNOLOGY

Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer

(2019) Hadar Reichman et al.   Cancer Immunology Research

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis

(2019) Ting Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF

(2019) Ryan K. Nelson et al.   JOURNAL OF IMMUNOLOGY

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

(2018) Mats W. Johansson et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis

(2018) Ikuo Hirano et al.   GASTROENTEROLOGY

Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis

(2017) Mark Rochman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Calpain-14 and its association with eosinophilic esophagitis

(2017) Vladislav A. Litosh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetics of eosinophilic esophagitis

(2017) L C Kottyan et al.   Mucosal Immunology

CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production

(2017) Perri Rozenberg et al.   Scientific Reports

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

(2016) Reiko Sugawara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paired Ig-like Receptor B Inhibits IL-13–Driven Eosinophil Accumulation and Activation in the Esophagus

(2016) Netali Ben Baruch-Morgenstern et al.   JOURNAL OF IMMUNOLOGY

Intravenous anti–IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis

(2015) Marc E. Rothenberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcription Factor Repertoire of Homeostatic Eosinophilopoiesis

(2015) Carine Bouffi et al.   JOURNAL OF IMMUNOLOGY

In Vitro Model for Studying Esophageal Epithelial Differentiation and Allergic Inflammatory Responses Identifies Keratin Involvement in Eosinophilic Esophagitis

(2015) Kiran KC et al.   PLoS One

Circulating Human Eosinophils Share a Similar Transcriptional Profile in Asthma and Other Hypereosinophilic Disorders

(2015) Cindy Barnig et al.   PLoS One

Eosinophil–Epithelial Cell Interactions Stimulate the Production of MUC5AC Mucin and Profibrotic Cytokines Involved in Airway Tissue Remodeling

(2014) Shino Shimizu et al.   American Journal of Rhinology & Allergy

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

(2014) Joanne C Masterson et al.   GUT

IL-5 Triggers a Cooperative Cytokine Network That Promotes Eosinophil Precursor Maturation

(2014) Patricia C. Fulkerson et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

(2014) Leah C Kottyan et al.   NATURE GENETICS

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis

(2014) Bahram Namjou et al.   Frontiers in Genetics

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

(2013) E. A. Jacobsen et al.   ALLERGY

IL-5 Induces Suspended Eosinophils to Undergo Unique Global Reorganization Associated with Priming

(2013) Shih-Tsung Han et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis

(2013) Iris M. Otani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis

(2013) J D Sherrill et al.   Mucosal Immunology

Anti-IL-5 attenuates activation and surface density of β2-integrins on circulating eosinophils after segmental antigen challenge

(2012) M. W. Johansson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Markers of Antigen Presentation and Activation on Eosinophils and T Cells in the Esophageal Tissue of Patients With Eosinophilic Esophagitis

(2012) Minou Le-Carlson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis

(2011) Amal H. Assa'ad et al.   GASTROENTEROLOGY

Distinctive Blood Eosinophilic Phenotypes and Cytokine Patterns in Eosinophilic Esophagitis, Inflammatory Bowel Disease and Airway Allergy

(2011) Marianne Johnsson et al.   Journal of Innate Immunity

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

IL-13 Induces Esophageal Remodeling and Gene Expression by an Eosinophil-Independent, IL-13R 2-Inhibited Pathway

(2010) L. Zuo et al.   JOURNAL OF IMMUNOLOGY

GM-CSF: a role in immune and inflammatory reactions in the intestine

(2010) Laia Egea et al.   Expert Review of Gastroenterology & Hepatology

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial

(2009) A Straumann et al.   GUT

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils

(2008) W. Brett Cherry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways

(2007) Esra Nutku-Bilir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY