What is the contribution of IgE to nasal polyposis?

Staphylococcus aureus and its IgE-inducing Enterotoxins in Asthma: Current Knowledge

(2020) Claus Bachert et al.   EUROPEAN RESPIRATORY JOURNAL

Biologics for chronic rhinosinusitis with nasal polyps

(2020) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

(2020) Tetsuji Takabayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

(2020) Pascal Gasser et al.   Nature Communications

IgMand IgA in addition to IgG autoantibodiesagainst FcεRIα are frequent and associated with disease markers of chronic spontaneous urticarial

(2020) Sabine Altrichter et al.   ALLERGY

Does IgE Have a Role in AERD?

(2020) William W Busse   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Omalizumab for Aspirin-Hypersensitivity and Leukotriene Overproduction in Aspirin-Exacerbated Respiratory Disease: A Randomized Trial

(2020) Hiroaki Hayashi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Add-on omalizumab for inadequately controlled severe pollinosis despite standard-of-care: a randomized study

(2020) Kimihiro Okubo et al.   Journal of Allergy and Clinical Immunology-In Practice

Omalizumab restores the ability of human plasmacytoid dendritic cells to induce Foxp3+Tregs

(2020) Jacobo López-Abente et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials

(2020) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: Definitions and management

(2020) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab in “non–IgE-mediated” diseases

(2020) R. Sharon Chinthrajah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endoscopic Sinus Surgery for Type-2 CRS wNP: An Endotype-Based Retrospective Study

(2019) Saeed Alsharif et al.   LARYNGOSCOPE

Association of Chronic Rhinosinusitis With Depression and Anxiety in a Nationwide Insurance Population

(2019) Jong-Yeup Kim et al.   JAMA Otolaryngology-Head & Neck Surgery

Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses

(2019) Mohamed H. Shamji et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

(2019) Emma K. Persson et al.   SCIENCE

Sensitisation to staphylococcal enterotoxins and asthma severity: a longitudinal study in the EGEA cohort

(2019) Ina Sintobin et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic Rhinosinusitis with Nasal Polyps

(2019) Claire Hopkins   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

Aspirin-exacerbated respiratory disease (AERD): Current understanding of AERD

(2019) Masami Taniguchi et al.   ALLERGOLOGY INTERNATIONAL

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis

(2019) Lien Calus et al.   Clinical and Translational Allergy

Chronic Rhinosinusitis with Nasal Polyps in Older Adults: Clinical Presentation, Pathophysiology, and Comorbidity

(2019) Woo-Jung Song et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials

(2019) Claus Bachert et al.   LANCET

Staphylococcus aureus Orchestrates Type 2 Airway Diseases

(2019) Andrea R. Teufelberger et al.   TRENDS IN MOLECULAR MEDICINE

Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma

(2019) William W. Busse et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

In chronic spontaneous urticaria, IgE against staphylococcal enterotoxins is common and functional

(2018) S. Altrichter et al.   ALLERGY

Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: a randomized, double-blind, placebo-controlled study

(2018) Martin Metz et al.   ALLERGY

Omalizumab can inhibit respiratory reaction during aspirin desensitization

(2018) David M. Lang et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy

(2018) M. Berings et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The role and relevance of mast cells in urticaria

(2018) Martin K. Church et al.   IMMUNOLOGICAL REVIEWS

Atopic Comorbidities and Biomarkers of Type 2 Inflammation in Patients With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) Who Failed Intranasal Corticosteroids

(2018) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nasal polyp IgE and IgG4 levels are elevated in aspirin-exacerbated respiratory disease

(2018) Kathleen M. Buchheit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Staphylococcus aureus controls interleukin-5 release in upper airway inflammation

(2018) C. Bachert et al.   Journal of Proteomics

Elevated IgE to tissue factor and thyroglobulin are abated by omalizumab in chronic spontaneous urticaria

(2018) Massimo Cugno et al.   ALLERGY

Total IgE levels are linked to the response of chronic spontaneous urticaria patients to omalizumab

(2018) Karsten Weller et al.   ALLERGY

Biomarkers in Chronic Rhinosinusitis with Nasal Polyps

(2018) Alan D. Workman et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Omalizumab for Severe Asthma: Beyond Allergic Asthma

(2018) C. C. Loureiro et al.   Biomed Research International

IgE-Mediated Food Allergy

(2018) Sara Anvari et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

(2018) Heleen Scheerens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies

(2017) Óscar Palomares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease

(2017) Katherine N. Cahill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized multicenter study evaluating Xolair persistence of response after long-term therapy

(2017) Dennis Ledford et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria

(2017) Janine Gericke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria

(2017) Oliver Schmetzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Plasmacytoid dendritic cells drive acute asthma exacerbations

(2017) Aikaterini-Dimitra Chairakaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial

(2017) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoimmune chronic spontaneous urticaria: What we know and what we do not know

(2017) Pavel Kolkhir et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation

(2017) Elien Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of human and Staphylococcus aureus proteins in respiratory mucosa by in vivo- and immunoproteomics

(2017) Frank Schmidt et al.   Journal of Proteomics

The effect of endoscopic sinus surgery on quality of life and absenteeism in patients with chronic rhinosinuitis - a multi-centre study

(2017) P. Sahlstrand-Johnson et al.   RHINOLOGY

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin

(2017) Martin Metz et al.   Theranostics

The response to nasal allergen provocation with grass pollen is reduced in patients with chronic rhinosinusitis with nasal polyposis and grass sensitization

(2016) L. Calus et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Aspirin-exacerbated respiratory disease and current treatment modalities

(2016) Emine Güven Sakalar et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Omalizumab reduces bronchial mucosal IgE and improves lung function in non-atopic asthma

(2016) Prathap Pillai et al.   EUROPEAN RESPIRATORY JOURNAL

The quest for autoreactive antibodies in nasal polyps

(2016) Els De Schryver et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab reduces cysteinyl leukotriene and 9α,11β-prostaglandin F 2 overproduction in aspirin-exacerbated respiratory disease

(2016) Hiroaki Hayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diversity of T H cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania

(2016) Xiangdong Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

(2016) Peter Tomassen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis

(2016) Adam S. DeConde et al.   LARYNGOSCOPE

Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study)

(2016) Robert M Niven et al.   BMJ Open

Chronic Rhinosinusitis with Nasal Polyps

(2016) Whitney W. Stevens et al.   Journal of Allergy and Clinical Immunology-In Practice

Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease

(2015) Whitney W. Stevens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prevalence of Nasal Polyps and its Risk Factors: Korean National Health and Nutrition Examination Survey 2009-2011

(2015) Jaewoon We et al.   American Journal of Rhinology & Allergy

Altered Quality of Life and Psychological Health (SCL-90-R) in Patients With Chronic Rhinosinusitis With Nasal Polyps

(2015) Jae Ho Chung et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

T-cell regulation during viral and nonviral asthma exacerbations

(2015) Agnieszka S. Wegrzyn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis

(2015) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

(2015) S Palaniyandi et al.   Mucosal Immunology

Local Immunoglobulin E in the Nasal Mucosa: Clinical Implications

(2015) Els De Schryver et al.   Allergy Asthma & Immunology Research

Efficacy of tobramycin aerosol in nasal polyposis

(2015) P. Bonfils et al.   European Annals of Otorhinolaryngology-Head and Neck Diseases

Elevated Total Serum IgE in Nonatopic Patients with Aspirin-exacerbated Respiratory Disease

(2014) Christina B. Johns et al.   American Journal of Rhinology & Allergy

Human Eosinophils Express the High Affinity IgE Receptor, FcεRI, in Bullous Pemphigoid

(2014) Kelly N. Messingham et al.   PLoS One

New strategies with anti-IgE in allergic diseases

(2014) Stephen T Holgate   World Allergy Organization Journal

Determining the Role of Allergy in Sinonasal Disease

(2013) Russell A. Settipane et al.   American Journal of Rhinology & Allergy

Inflammatory Patterns in Upper Airway Disease in the Same Geographical Area may Change over Time

(2013) Michael Katotomichelakis et al.   American Journal of Rhinology & Allergy

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

(2013) Hye-Soo Yoo et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Significantly High Levels of Anti-dsDNA Immunoglobulin E in Sera and the Ability of dsDNA to Induce the Degranulation of Basophils from Chronic Urticaria Patients

(2013) Yuko Hatada et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis

(2013) Bruce K. Tan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic rhinosinusitis and asthma: novel understanding of the role of IgE ‘above atopy’

(2013) C. Bachert et al.   JOURNAL OF INTERNAL MEDICINE

Analysis of comorbidities and objective parameters in refractory chronic rhinosinusitis

(2013) Pete S. Batra et al.   LARYNGOSCOPE

Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria

(2013) Marcus Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

(2013) Marcia A Chan et al.   Clinical and Translational Allergy

Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps

(2012) P. Gevaert et al.   ALLERGY

Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

(2012) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

(2012) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Can anti-IgE therapy prevent airway remodeling in allergic asthma?

(2011) K. F. Rabe et al.   ALLERGY

Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase

(2011) Marcus Maurer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

(2011) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE Mediated Autoallergy against Thyroid Peroxidase – A Novel Pathomechanism of Chronic Spontaneous Urticaria?

(2011) Sabine Altrichter et al.   PLoS One

Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component

(2011) Diana Mechtcheriakova et al.   PLoS One

Mucosal tissue polyclonal IgE is functional in response to allergen and SEB

(2010) N. Zhang et al.   ALLERGY

Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization

(2010) Marie-Noëlle Corriveau et al.   American Journal of Rhinology & Allergy

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma

(2010) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of staphylococcal superantigens in upper airway disease

(2009) Claus Bachert et al.   Current Opinion in Allergy and Clinical Immunology

Effect of omalizumab on peripheral blood eosinophilia in allergic asthma

(2009) M. Massanari et al.   RESPIRATORY MEDICINE

Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease

(2008) Nan Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukotriene E4Activates Peroxisome Proliferator-activated Receptor γ and Induces Prostaglandin D2Generation by Human Mast Cells

(2008) Sailaja Paruchuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY