Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma

MYCN Function in Neuroblastoma Development

(2021) Jörg Otte et al.   Frontiers in Oncology

Innovative Therapies for Neuroblastoma: The Surprisingly Potent Role of Iron Chelation in Up-Regulating Metastasis and Tumor Suppressors and Down-Regulating the Key Oncogene, N-myc

(2021) Tharushi P. Wijesinghe et al.   PHARMACOLOGICAL RESEARCH

Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms

(2020) Silvia Paukovcekova et al.   Cancers

Neuroblastoma—A Neural Crest Derived Embryonal Malignancy

(2019) John Inge Johnsen et al.   Frontiers in Molecular Neuroscience

The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6

(2019) Sharleen V. Menezes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospho-Protein Arrays as Effective Tools for Screening Possible Targets for Kinase Inhibitors and Their Use in Precision Pediatric Oncology

(2019) Jakub Neradil et al.   Frontiers in Oncology

EGFR-TKIs resistance via EGFR-independent signaling pathways

(2018) Qian Liu et al.   Molecular Cancer

The novel dithiocarbamate, DpdtC suppresses HER2-overexpressed cancer cells by up-regulating NDRG1 via inactivation of HER2-ERK 1/2 signaling

(2018) Yun Yang et al.   Scientific Reports

WNK pathways in cancer signaling networks

(2018) Sachith Gallolu Kankanamalage et al.   Cell Communication and Signaling

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

(2017) Mark W. Zimmerman et al.   Cancer Discovery

N-myc downstream-regulated gene 1 promotes apoptosis in colorectal cancer via up-regulating death receptor 4

(2017) Xian Zhang et al.   Oncotarget

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature)

(2017) Xinan Yang et al.   Scientific Reports

Ndrg1 promotes adipocyte differentiation and sustains their function

(2017) Kai Cai et al.   Scientific Reports

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

(2016) Zhu-Ling Guo et al.   Journal of Hematology & Oncology

Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells

(2016) Jung Lim Kim et al.   TUMOR BIOLOGY

Neuroblastoma

(2016) Katherine K. Matthay et al.   Nature Reviews Disease Primers

Co-Expression of Cancer Stem Cell Markers Corresponds to a Pro-Tumorigenic Expression Profile in Pancreatic Adenocarcinoma

(2016) Jan Skoda et al.   PLoS One

Identification of patient subgroups with markedly disparate rates ofMYCNamplification in neuroblastoma: A report from the International Neuroblastoma Risk Group project

(2015) Daria Thompson et al.   CANCER

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

(2015) Patric J. Jansson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

(2015) Zaklina Kovacevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1

(2015) Wensheng Liu et al.   Oncotarget

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

(2015) Vit Sestak et al.   Oncotarget

Targeting cancer by binding iron: Dissecting cellular signaling pathways

(2015) Goldie Y.L. Lui et al.   Oncotarget

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential

(2014) Himisha Beltran   MOLECULAR CANCER RESEARCH

Role of AKT signaling in DNA repair and clinical response to cancer therapy

(2014) Q. Liu et al.   NEURO-ONCOLOGY

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

(2014) Maciej Serda et al.   PLoS One

Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control

(2014) Caiguo Zhang   Protein & Cell

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells

(2013) K M Dixon et al.   BRITISH JOURNAL OF CANCER

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

(2013) V. Pietiainen et al.   JOURNAL OF CELL SCIENCE

The role of NDRG1 in the pathology and potential treatment of human cancers

(2013) Dong-Hun Bae et al.   JOURNAL OF CLINICAL PATHOLOGY

Low NDRG1 mRNA expression predicts a poor prognosis in neuroblastoma patients

(2013) Kohei Matsushita et al.   PEDIATRIC SURGERY INTERNATIONAL

SIRT2 directs the replication stress response through CDK9 deacetylation

(2013) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

(2013) M. Weiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Prospective Study of Expectant Observation as Primary Therapy for Neuroblastoma in Young Infants

(2012) Jed G. Nuchtern et al.   ANNALS OF SURGERY

The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways

(2012) Zaklina Kovacevic et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRR1 Enhances EGF-Mediated MYCN Induction in Neuroblastoma and Accelerates Tumor Growth In Vivo

(2012) S. Hossain et al.   CANCER RESEARCH

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)

(2012) Zhiqiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-myc downstream-regulated gene 1/Cap43 may function as tumor suppressor in endometrial cancer

(2012) Xiu-Hong Lv et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Children's Oncology Group's 2013 blueprint for research: Neuroblastoma

(2012) Julie R. Park et al.   PEDIATRIC BLOOD & CANCER

Outcome after Reduced Chemotherapy for Intermediate-Risk Neuroblastoma

(2010) David L. Baker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Switching Akt: from survival signaling to deadly response

(2009) Marek Los et al.   BIOESSAYS

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region

(2008) Jian Zhang et al.   GENE

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

(2008) Frank Westermann et al.   GENOME BIOLOGY