Neuroblastoma—A Neural Crest Derived Embryonal Malignancy

Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

(2018) Tanmoy Mondal et al.   CANCER CELL

Spontaneous regression of neuroblastoma

(2018) Garrett M. Brodeur   CELL AND TISSUE RESEARCH

Molecular mechanisms and therapeutic targets in neuroblastoma

(2018) John Inge Johnsen et al.   PHARMACOLOGICAL RESEARCH

The Expanding World of N-MYC–Driven Tumors

(2018) David S. Rickman et al.   Cancer Discovery

Patient-derived xenograft models reveal intratumor heterogeneity and temporal stability in neuroblastoma

(2018) Noémie Braekeveldt et al.   CANCER RESEARCH

Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor

(2018) Flora Cimmino et al.   INTERNATIONAL JOURNAL OF CANCER

From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion?

(2018) Sabine Wislet et al.   Frontiers in Molecular Neuroscience

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project

(2017) Lucas Moreno et al.   Expert Opinion on Drug Discovery

Advances in emerging drugs for the treatment of neuroblastoma

(2017) Pablo Berlanga et al.   EXPERT OPINION ON EMERGING DRUGS

Overview and recent advances in the treatment of neuroblastoma

(2017) Sarah B. Whittle et al.   Expert Review of Anticancer Therapy

Irinotecan–temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial

(2017) Rajen Mody et al.   LANCET ONCOLOGY

Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial

(2017) Ruth Ladenstein et al.   LANCET ONCOLOGY

MYCN induces neuroblastoma in primary neural crest cells

(2017) R R Olsen et al.   ONCOGENE

Rho-associated kinase is a therapeutic target in neuroblastoma

(2017) Cecilia Dyberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroblastoma

(2017) Jason Shohet et al.   BMJ-British Medical Journal

Neuroblastoma

(2017) Jason Shohet et al.   BMJ-British Medical Journal

Dualistic Role of BARD1 in Cancer

(2017) Flora Cimmino et al.   Genes

The role of the ALK receptor in cancer biology

(2016) B. Hallberg et al.   ANNALS OF ONCOLOGY

Slit-Robo signaling

(2016) Heike Blockus et al.   DEVELOPMENT

The SWI/SNF BAF-A complex is essential for neural crest development

(2016) Ronald L. Chandler et al.   DEVELOPMENTAL BIOLOGY

Neuroblastoma

(2016) Katherine K. Matthay et al.   Nature Reviews Disease Primers

Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations

(2015) Kristopher R. Bosse et al.   CANCER

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis

(2015) Robert W. Schnepp et al.   CANCER CELL

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus

(2015) M. R. Russell et al.   CANCER RESEARCH

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

(2015) Martin Peifer et al.   NATURE

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

(2015) Derek A. Oldridge et al.   NATURE

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

(2015) Thomas F Eleveld et al.   NATURE GENETICS

Mutational dynamics between primary and relapse neuroblastomas

(2015) Alexander Schramm et al.   NATURE GENETICS

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

(2015) Linda J Valentijn et al.   NATURE GENETICS

Neuroblastoma

(2015) Meredith S. Irwin et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

(2015) Alex Cazes et al.   Oncotarget

Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations inSMARCB1,SMARCA4,SMARCE1, andARID1A

(2014) Tomoki Kosho et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation

(2014) Gaurav Kumar Pandey et al.   CANCER CELL

ALK Mutations Confer Differential Oncogenic Activation and Sensitivity to ALK Inhibition Therapy in Neuroblastoma

(2014) Scott C. Bresler et al.   CANCER CELL

Common Genetic Variants in NEFL Influence Gene Expression and Neuroblastoma Risk

(2014) M. Capasso et al.   CANCER RESEARCH

Insight into planar cell polarity

(2014) Michael Sebbagh et al.   EXPERIMENTAL CELL RESEARCH

Metastatic Neuroblastoma Confined to Distant Lymph Nodes (stage 4N) Predicts Outcome in Patients With Stage 4 Disease: A Study From the International Neuroblastoma Risk Group Database

(2014) Daniel A. Morgenstern et al.   JOURNAL OF CLINICAL ONCOLOGY

Emergence of New ALK Mutations at Relapse of Neuroblastoma

(2014) Gudrun Schleiermacher et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanisms of neuroblastoma regression

(2014) Garrett M. Brodeur et al.   Nature Reviews Clinical Oncology

Genomic organization and evolution of double minutes/homogeneously staining regions withMYCamplification in human cancer

(2014) Alberto L'Abbate et al.   NUCLEIC ACIDS RESEARCH

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

(2014) K Althoff et al.   ONCOGENE

Suppression of Cpn10 Increases Mitochondrial Fission and Dysfunction in Neuroblastoma Cells

(2014) So Jung Park et al.   PLoS One

Ch14.18 antibody produced in CHO cells in relapsed or refractory Stage 4 neuroblastoma patients

(2013) Ruth Ladenstein et al.   mAbs

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Long-term results of the combination of the N7 induction chemotherapy and the busulfan-melphalan high dose chemotherapy

(2013) Dominique Valteau-Couanet et al.   PEDIATRIC BLOOD & CANCER

Boundary formation in the development of the vertebrate hindbrain

(2013) Qiling Xu et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma

(2012) Teeara Berry et al.   CANCER CELL

Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis

(2012) Shizhen Zhu et al.   CANCER CELL

Common Variation at BARD1 Results in the Expression of an Oncogenic Isoform That Influences Neuroblastoma Susceptibility and Oncogenicity

(2012) K. R. Bosse et al.   CANCER RESEARCH

Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility

(2012) Mario Capasso et al.   CARCINOGENESIS

Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

(2012) Nai-Kong V. Cheung   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma

(2012) Sharon J Diskin et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

(2012) Mark Sausen et al.   NATURE GENETICS

Essential Roles of Gangliosides in the Formation and Maintenance of Membrane Microdomains in Brain Tissues

(2012) Yuhsuke Ohmi et al.   NEUROCHEMICAL RESEARCH

Tumor Development, Growth Characteristics and Spectrum of Genetic Aberrations in the TH-MYCN Mouse Model of Neuroblastoma

(2012) Agnes Rasmuson et al.   PLoS One

Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice

(2012) L. C. Heukamp et al.   Science Translational Medicine

Rare Copy Number Variations in Adults with Tetralogy of Fallot Implicate Novel Risk Gene Pathways

(2012) Candice K. Silversides et al.   PLoS Genetics

Expression of GD2 and GD3 Gangliosides in Human Embryonic Neural Stem Cells

(2011) Makoto Yanagisawa et al.   ASN Neuro

The Neuronal Differentiation Factor NeuroD1 Downregulates the Neuronal Repellent Factor Slit2 Expression and Promotes Cell Motility and Tumor Formation of Neuroblastoma

(2011) P. Huang et al.   CANCER RESEARCH

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

(2011) T. Reiff et al.   DEVELOPMENT

Transcriptional control of differentiation and neurogenesis in autonomic ganglia

(2011) Hermann Rohrer   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroblastoma: Biology, Prognosis, and Treatment

(2010) Julie R. Park et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Neuroblastoma Phox2b Variants Stimulate Proliferation and Dedifferentiation of Immature Sympathetic Neurons

(2010) T. Reiff et al.   JOURNAL OF NEUROSCIENCE

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

(2010) Kai Wang et al.   NATURE

Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma

(2010) Alice L. Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset

(2010) H. Caren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription

(2010) Liling Tang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Embryonal neural tumours and cell death

(2009) John Inge Johnsen et al.   APOPTOSIS

Anaplastic lymphoma kinase: signalling in development and disease

(2009) Ruth H. Palmer et al.   BIOCHEMICAL JOURNAL

International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee

(2009) P F Ambros et al.   BRITISH JOURNAL OF CANCER

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

(2009) C. Hahmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

On Trk--The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer Biology

(2009) C. J. Thiele et al.   CLINICAL CANCER RESEARCH

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

Long-Term Results for Children With High-Risk Neuroblastoma Treated on a Randomized Trial of Myeloablative Therapy Followed by 13-cis-Retinoic Acid: A Children's Oncology Group Study

(2009) Katherine K. Matthay et al.   JOURNAL OF CLINICAL ONCOLOGY

Copy number variation at 1q21.1 associated with neuroblastoma

(2009) Sharon J. Diskin et al.   NATURE

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

(2009) Mario Capasso et al.   NATURE GENETICS

The International Neuroblastoma Risk Group (INRG) Staging System: An INRG Task Force Report

(2008) Tom Monclair et al.   JOURNAL OF CLINICAL ONCOLOGY

High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial

(2008) Andrew DJ Pearson et al.   LANCET ONCOLOGY

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

(2008) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma

(2008) John M. Maris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE